J0166 NDC Crosswalk, Billing Units, ASP Payment & Medicare Reimbursement

📋 J0166 summary

J0166 is a HCPCS Level II J-code used to bill epinephrine (bpi), billed per 0.1 MG. The number of billing units to report depends on the dose administered and the NDC/package billed — use the calculator below.

Code J0166 Billing unit 0.1 MG Payment limit $0.669/unit NDC-Crosswalk 11 Quarter Q3 2026 RxCUI Atlas Trace the drug concept →

⚠ An NDC↔HCPCS crosswalk and a published payment limit do not guarantee payer coverage or payment. Always verify the current payer policy and claim format before billing.

🗂️ Key billing facts

HCPCS codeJ0166

DescriptorInj epinephrine (bpi)

Billing unit0.1 MG

Payment limit / unit$0.669

Est. ASP / unit$0.631 est.

Mapped NDCs11

Data periodQ3 2026

Last updated2026-08-20

💊 About Epinephrine DRUG GUIDE

Epinephrine is used for the emergency treatment of severe allergic reactions (Type I), including anaphylaxis.

Triggers can include insect stings or bites, foods, drugs, diagnostic substances, allergen immunotherapy, or unknown causes (idiopathic anaphylaxis) and exercise-induced anaphylaxis.

These reactions can cause life-threatening symptoms such as throat swelling, wheezing, a dangerous drop in blood pressure, hives, and vomiting.Adrenalin (injection) is also indicated to raise blood pressure in adult patients with low blood pressure caused by septic shock.

Primatene Mist (inhaler) is used for temporary relief of mild symptoms of intermittent asthma — including wheezing, chest tightness, and shortness of breath.

Read the full Epinephrine drug guide →

Clinical overview from our editorial drug guide for Epinephrine. For billing reference, see the sections above.

🧾 Billing & reimbursement HCPCS · CMS · EFF. Q3 2026

📅 Payment limits effective Q3 2026 — from the CMS Medicare Part B Payment Limit File (revised quarterly).

Medicare payment limit / unit

$0.669

Est. ASP / unit

$0.631 est.

Est. after 2% sequester

$0.656

HCPCS dosage

0.1 MG

The CMS payment limit is the Medicare Part B drug allowance (ASP + 6%, statutory). After the 2% federal sequester the effective payment is ≈ ASP + 4.3%; estimated ASP = payment limit ÷ 1.06. Source: CMS Medicare Part B Payment Limit File (quarterly), Q3 2026.

🧮 Dosing & billing-units calculator HCPCS UNITS

One billing unit of J0166 = 0.1 mg. Enter a regimen to convert dose → billing units and project a full course.

Dose per administration (mg) Frequency — every days Number of doses NDC / package billed (optional)

Billing units = dose ÷ HCPCS unit size. Most payers require whole units — round per the payer's policy. “Est. Medicare pay” uses the current payment limit. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (JZ when none is discarded) where allowed. Always verify payer-specific rounding before billing.

🔁 NDCs that bill under J0166 WITH EST. MEDICARE PAY

11 NDCs map to J0166. Bill units = how many HCPCS units one package represents. Est. pay / pkg = payment limit ($0.669/unit) × that package's bill units.

NDC (11-digit)	Drug	Labeler	Package	Strength	Bill units	Est. pay / pkg	NADAC / unit	Status	Source
00404-9857-01	EPINEPHRINE 1 mg/mL INJECTION, SOLUTION, CONCENTRATE	Henry	1 AMPULE in 1 BAG (0404-9857-01) / 1 mL i...	1 mg/mL	10	$6.69	—	● Active	CMS ASP
50090-3039-01	Epinephrine 1 mg/mL INJECTION, SOLUTION, CONCENTRATE	A-S	1 mL in 1 AMPULE (50090-3039-1)	1 mg/mL	10	$6.69	—	● Active	CMS ASP
50090-3039-02	Epinephrine HCl	A-S	—	—	100	$66.90	—	—	CMS ASP
63323-0696-25	EPINEPHRINE 1 mg/mL INJECTION, SOLUTION, CONCENTRATE	Fresenius	25 VIAL, SINGLE-DOSE in 1 TRAY (63323-696-...	1 mg/mL	250	$167.25	—	● Active	CMS + PDAC
68462-0760-10	epinephrine 1 mg/mL INJECTION	GLENMARK	1 VIAL, MULTI-DOSE in 1 CARTON (68462-760-...	1 mg/mL	100	$66.90	—	● Active	CMS + PDAC
68462-0761-30	epinephrine 1 mg/mL INJECTION	GLENMARK	1 VIAL, MULTI-DOSE in 1 CARTON (68462-761-...	1 mg/mL	300	$200.70	—	● Active	CMS + PDAC
68462-0933-10	epinephrine 1 mg/mL INJECTION, SOLUTION, CONCENTRATE	GLENMARK	10 AMPULE in 1 BOX (68462-933-10) / 1 mL...	1 mg/mL	100	$66.90	—	● Active	CMS + PDAC
54288-0119-25	EPINEPHRINE 1 mg/mL INJECTION	BPI	25 VIAL in 1 CARTON (54288-119-25) / 1 mL...	1 mg/mL	10	$6.69	—	● Active	PDAC
54288-0120-01	EPINEPHRINE 1 mg/mL INJECTION	BPI	1 VIAL in 1 CARTON (54288-120-01) / 10 mL...	1 mg/mL	10	$6.69	—	● Active	PDAC
54288-0152-01	EPINEPHRINE 30 mg/30mL INJECTION	BPI	1 VIAL in 1 CARTON (54288-152-01) / 30 mL...	30 mg/30mL	10	$6.69	—	● Active	PDAC
54288-0600-01	EPINEPHRINE 1 mg/mL INJECTION	BPI	1 VIAL in 1 CARTON (54288-600-01) / 10 mL...	1 mg/mL	10	$6.69	—	● Active	PDAC

NDC→HCPCS mappings come from the CMS ASP NDC-HCPCS crosswalk; additional DME MAC / DMEPOS mappings come from PDAC and are labeled separately. NADAC from CMS (weekly). “Status” reflects the product's marketing / obsolete flag in the NDC directory. Presence or absence here does not determine Medicare coverage. Linked NDCs open the full product page.

⚠️ Don't confuse J0166 with… RELATED CODES

Adjacent HCPCS codes that share an ingredient or formulation with J0166. Billing units and payment limits differ — confirm the exact code, strength and form before billing.

Code	Descriptor	Billing unit	Payment limit / unit	How it differs from J0166
J0171	Adrenalin epinephrine inject	—	—	Related ingredient or formulation — confirm strength, form and billing unit before substituting.
J0169	EPINEPHRINE	0.1 MG	$0.783	Related ingredient or formulation — confirm strength, form and billing unit before substituting.
J0165	EPINEPHRINE*	0.1 MG	$0.234	Related ingredient or formulation — confirm strength, form and billing unit before substituting.

Related codes matched on shared ingredient (CMS Medicare Part B Spending feed). Billing units and payment limits from the CMS ASP Pricing File. Always verify the precise HCPCS code for the product and strength administered.

📊 Medicare utilization & spend CMS · PART B · 2026 (Q1)

Period

Total Part B spend

$125.51

Claims

24

Beneficiaries

24

Spend / beneficiary

$5.23

Spend / claim

$5.23

Trend by period

Where J0166 ranks among Part B drugs · 2026 (Q1) · neighbors ±5

Total spending — #810 of 824

#805 NALOXONE HCL(J2312) J2312 $175.36 #806 DILTIAZEM HCL-0.9% N... J1163 $166.44 #807 ADRENALIN(J0165)* J0165 $164.81 #808 PROGESTERONE J2675 $144.09 #809 LIDOCAINE HCL IN 5%... J2002 $140.95 #810 EPINEPHRINE J0166 $125.51 #811 VFEND IV* J3465 $119.85 #812 HALOPERIDOL LACTATE J1630 $88.45 #813 CLINDAMYCIN-0.9% NAC... J0737 $73.78 #814 CEFAZOLIN SODIUM(J06... J0688 $69.34 #815 HEPARIN SODIUM J1643 $64.49

Total claims — #767 of 824

#762 TROGARZO J1746 25 #763 ALDURAZYME J1931 25 #764 ESPEROCT J7204 25 #765 ACTEMRA(Q0249) Q0249 25 #766 INTEGRA MATRIX** Q4108 25 #767 EPINEPHRINE J0166 24 #768 HEPAGAM B(J1573) J1573 24 #769 YUTIQ J7314 24 #770 GAMIFANT J9210 24 #771 COMBOGESIC IV J0138 23 #772 CEFAZOLIN SODIUM(J06... J0688 23

Full breakdown by period (2)

Period	Total spend	Beneficiaries	Claims	$/beneficiary	$/claim
2026 (Q1)	$125.51	24	24	$5.23	$5.23
2025 (Q1-Q4)	$417.15	48	48	$8.69	$8.69

Provider-administered (Part B) spend, calculated for the whole HCPCS code (CMS does not publish Medicare spend per individual NDC). Self-administered use is covered under Part D instead. A blank patient count means fewer than 11 people — CMS hides counts that small to protect privacy. Source: CMS Medicare Quarterly Part B Spending by Drug (data.cms.gov), updated quarterly.

📈 Medicare Part B claims detail CMS PSPS · 2024

Calendar-year 2024 Medicare Part B fee-for-service activity for this HCPCS code, summed across all carriers, localities and specialties (CMS Physician/Supplier Procedure Summary). A “service” is one billed line/unit — not one claim — so counts run higher than claim counts.

Allowed charges

$188.90

Medicare paid

$313.87

Submitted services

1,455

Denial rate

90.4%

Allowed / service

$1.35

Submitted charges

$6.8K

Source: CMS Physician/Supplier Procedure Summary (PSPS), CY2024 — Medicare Part B carrier + DME fee-for-service claims (excludes Medicare Advantage). Figures are for the whole HCPCS code, which may cover uses beyond this drug. ⚠ CMS hides any figure covering fewer than 11 patients (a privacy rule), so totals — especially denials and low-volume codes — run a little low.

🗺️ Where J0166 is utilized

⏳

The geographic utilization map is building for this code — it aggregates millions of CMS Part B claim lines, then caches the result. Refresh in a moment; if it doesn’t appear, this code may have no reportable Part B utilization.

📊 What bills under J0166

J-codes are billing codes often used for drugs billed under the medical benefit. This connects the billing code to the NDC package records it covers, by ingredient and labeler.

NDC products by ingredient

EPINEPHRINE 6

epinephrine 3

NDC products by labeler

BPI Labs, LLC 4

GLENMARK PHARMACEUTICALS INC., USA 3

Fresenius Kabi USA, LLC 2

🔗 Related NDC directory pages

🧪 All Epinephrine NDCsIngredient 🧪 All Epinephrine NDCsIngredient 🏭 All BPI labeler NDCsLabeler 54288 🏭 All GLENMARK labeler NDCsLabeler 68462 🏭 All Fresenius labeler NDCsLabeler 63323 📚 All Catecholamine NDCsDrug class 📚 All alpha-Adrenergic Agonist NDCsDrug class 📚 All beta-Adrenergic Agonist NDCsDrug class

🗃️ Data sources & freshness

Every figure on this page is computed from public datasets. Here's what each section draws on and how current it is.

HCPCS code & descriptor

CMS HCPCS Level II code file

Not available in current dataset

Payment limit & billing unit

CMS Medicare Part B ASP Pricing File (quarterly)

Q3 2026 · as of 2026-08-20

NDC ↔ HCPCS crosswalk

CMS ASP NDC-HCPCS crosswalk + DMEPDAC (PDAC)

11 NDCs mapped

NADAC acquisition cost

CMS National Average Drug Acquisition Cost (weekly)

Not available for mapped NDCs

Utilization & spend

CMS Part B Spending by Drug · PSPS · Physician & Other Practitioners

Latest data year 2026

Figures are estimates for reference and may lag the source files. Always verify against the current CMS files and your payer's policy before submitting claims.

⚠️ Practical billing caveats

A crosswalk is not coverage. An NDC mapping or a published payment limit does not guarantee a payer will cover or pay this code. Check the specific plan's policy.
Units ≠ milligrams. Bill the number of HCPCS units (dose ÷ the code's unit size), not the milligram dose. Use the calculator above.
Discarded drug. For single-dose vials, drug discarded after administration may be separately billable with modifier JW (and JZ when nothing is discarded) where the payer allows.
Rounding & partial units. Many payers require whole units; round per the payer's policy, not automatically up.
The code can cover more than this drug. Some HCPCS codes span multiple products or strengths — confirm the exact code for the product administered.
Figures lag. ASP limits change quarterly and utilization data are released with a delay. Verify against the current CMS files before billing.

❓ J0166 billing FAQ

What is HCPCS code J0166?

J0166 is a HCPCS Level II J-code used to bill Inj epinephrine (bpi) under Medicare Part B and most medical (not pharmacy) benefits.

What is the billing unit for J0166?

One unit of J0166 represents 0.1 MG. Report the number of units equal to the dose administered divided by 0.1 MG.

How many units of J0166 should I bill?

Divide the dose administered by the code's unit size (0.1 MG) to get the number of billing units, then round per your payer's policy. The calculator on this page converts a dose into billing units and projects a full course.

How much does Medicare pay for J0166?

The Medicare Part B payment limit is $0.669 per unit (Q3 2026), based on ASP + 6%. After the 2% sequester the effective payment is about $0.656 per unit. Payment limits are revised quarterly.

Which NDCs bill under J0166?

11 NDCs currently map to J0166 in the CMS ASP NDC-HCPCS crosswalk. See the NDC crosswalk table above for each product, package, billing units and estimated reimbursement.

Does a crosswalk mean J0166 is covered?

No. An NDC-to-HCPCS crosswalk and a published payment limit do not guarantee coverage or payment. Coverage depends on the payer, the diagnosis and the site of care — always verify the current policy before billing.

J0166 – Inj epinephrine (bpi) · NDC Crosswalk & Billing Units