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Acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG... — RxCUI 1297288

RxNorm drug concept · Semantic clinical drug
RxCUI 1297288 Semantic clinical drug · SCD ● Current RxNorm concept 73 FDA products 88 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1297288
Official nameAcetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine hydrochloride 5 MG Oral Capsule
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asAPAP 325 MG / Dextromethorphan Hydrobromide 10 MG / doxylamine succinate 6.25 MG / Phenylephrine Hydrochloride 5 MG Oral Capsule; acetaminophen 325 MG / dextromethorphan HBr 10 MG / doxylamine succinate 6.25 MG / phenylephrine HCl 5 MG Oral Capsule
FDA products mapped73
Package NDCs mapped88
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Phenylephrine: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • Yes, it's the same active ingredient, but used in very different ways depending on the form. The nasal spray delivers a tiny amount directly to the nasal lining to temporarily shri...
  • I see phenylephrine in nasal sprays at the pharmacy AND as an IV drug in the hospital — is it really the same medication?
  • You should check with your doctor first. Phenylephrine constricts blood vessels, which can raise blood pressure and put extra strain on the heart — even from a nasal spray. If you...
  • Can I use the nasal spray if I have high blood pressure or heart disease?
📖 Read our full Phenylephrine guide →

🕸️ Concept Web — How Acetaminophen 325 MG / dextromethorphan hydrobro... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / doxylamine succinate 6.25 MG / phenylephrine hydrochloride 5 MG Oral Capsule RxCUI 1297288

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 8

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Dextromethorphan 3289
    • Doxylamine 3642
    • Phenylephrine 8163
    • Acetaminophen / dextromethorphan / doxylamine / phenylephrine 1008701
    • Dextromethorphan hydrobromide 102490
    • Doxylamine succinate 23665
    • Phenylephrine hydrochloride 8164
  2. Dose forms 9

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / dextromethorphan / doxylamine / phenylephrine Oral Capsule 1297287
    • Acetaminophen / dextromethorphan hydrobromide / doxylamine succinate / phenylephrine hydrochloride Oral Capsule 2646252
    • Acetaminophen / dextromethorphan / doxylamine / phenylephrine Oral Product 1155896
    • Acetaminophen / dextromethorphan / doxylamine / phenylephrine Pill 1297772
    • Acetaminophen / dextromethorphan hydrobromide / doxylamine succinate / phenylephrine hydrochloride Oral Product 2660518
    • Acetaminophen / dextromethorphan hydrobromide / doxylamine succinate / phenylephrine hydrochloride Pill 2661266
    • Oral Capsule 316965
    • Oral Product 1151131
    • +1 more in this family
  3. Clinical & branded drugs 4

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

    • Acetaminophen 325 MG 315263
    • Dextromethorphan hydrobromide 10 MG 1014455
    • Doxylamine succinate 6.25 MG 1052646
    • Phenylephrine hydrochloride 5 MG 1020198
  4. Packs 3

    Fixed collections of drugs packaged and sold together, like dose packs.

Showing up to 8 concepts per family — 23 of 24 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

📦 FDA Products & Package NDCs

73 products · 88 package NDCs
88 package NDCs map to RxCUI 1297288 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
49035-0586-04 1 KIT in 1 CARTON (49035-586-04) * 2 BLISTER PACK in 1 CAR... Day Severe Cold and Night Cold and Flu Maximum Strength Wal-Mart Stores, Inc. 2018-01-31
49035-0587-04 1 KIT in 1 CARTON (49035-587-04) * 2 BLISTER PACK in 1 CAR... Day and Night Sinus Relief Maximum Strength Wal-Mart Stores, Inc. 2018-01-31
49035-0674-16 1 KIT in 1 CARTON (49035-674-16) * 1 BLISTER PACK in 1 CAR... Maximum Strength Non Drowsy Day and Night Cold and Flu WAL-MART STORES INC 2020-11-16
51013-0168-08 1 KIT in 1 CARTON (51013-168-08) * 1 BLISTER PACK in 1 CAR... DG Day Time Cold and Flu Formula and Night Time Cold and Flu Formula PuraCap Pharmaceutical LLC 2016-06-15
51013-0169-08 2 BLISTER PACK in 1 CARTON (51013-169-08) / 10 CAPSULE, LIQ... Severe Sinus Congestion Allergy and Cough Formula PuraCap Pharmaceutical LLC 2016-06-29
51013-0175-04 2 BLISTER PACK in 1 CARTON (51013-175-04) / 12 CAPSULE, LIQ... Night Time Severe Cold and Flu Relief PuraCap Pharmaceutical LLC 2016-06-09
51316-0526-24 2 BLISTER PACK in 1 CARTON (51316-526-24) / 12 CAPSULE in 1... NIGHTTIME SEVERE COLD AND FLU CVS HEALTH CORP 2025-02-01
51316-0527-24 2 BLISTER PACK in 1 CARTON (51316-527-24) / 1 KIT in 1 BLIS... Daytime Nighttime Severe Cold and Flu CVS HEALTH CORP 2025-02-01
51316-0527-48 4 BLISTER PACK in 1 CARTON (51316-527-48) / 1 KIT in 1 BLIS... Daytime Nighttime Severe Cold and Flu CVS HEALTH CORP 2025-02-01
51316-0547-24 2 BLISTER PACK in 1 CARTON (51316-547-24) / 1 KIT in 1 BLIS... Ultra concentrated Daytime/ Nighttime Severe Softgel CVS PHARMACY, INC 2025-02-01
53345-0020-01 1 BAG in 1 BOX (53345-020-01) / 4000 CAPSULE, LIQUID FILLED... Night Cold Flu Cough and Allergy Humanwell PuraCap Pharmaceutical (Wuhan), Ltd. 2013-05-29
53345-0053-01 1 BAG in 1 BOX (53345-053-01) / 4000 CAPSULE, LIQUID FILLED... ASP Nighttime Max Humanwell PuraCap Pharmaceutical (Wuhan), Ltd. 2020-08-01
55319-0934-08 8 CAPSULE, LIQUID FILLED in 1 BLISTER PACK (55319-934-08) MAXIMUM STRENTH NIGHT COLD AND FLU FORMULA FAMILY DOLLAR 2020-08-02
55319-0935-02 1 KIT in 1 BLISTER PACK (55319-935-02) * 12 CAPSULE, LIQUI... MAXIMUM STRENGTH DAY-NIGHT COLD AND FLU FORMULA FAMILY DOLLAR 2020-08-02
63824-0519-24 1 KIT in 1 CARTON (63824-519-24) / 1 KIT in 1 KIT * 8 CAPS... Maximum Strength Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Reckitt Benckiser LLC 2018-07-28
63824-0519-48 2 KIT in 1 CARTON (63824-519-48) / 1 KIT in 1 KIT * 8 CAPS... Maximum Strength Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Reckitt Benckiser LLC 2018-07-28
68210-4210-01 1 BLISTER PACK in 1 CARTON (68210-4210-1) / 10 CAPSULE, LIQ... Maximum Strength Nighttime Severe Cold and Flu Prodose, Inc. 2022-08-19
69842-0442-24 1 BLISTER PACK in 1 CARTON (69842-442-24) / 1 KIT in 1 BLIS... MAXIMUM STRENGTH DAYTIME NIGHTTIME SINUS RELIEF CVS Pharmacy, Inc. 2021-07-10
69842-0451-24 1 BLISTER PACK in 1 CARTON (69842-451-24) / 1 KIT in 1 BLIS... MAXIMUM STRENGTH DAYTIME NIGHTTIME COLD AND FLU CVS Pharmacy, Inc. 2021-07-10
69842-0906-24 1 KIT in 1 KIT (69842-906-24) * 8 BLISTER PACK in 1 CARTON... Daytime Mucus Relief Severe Cold and Nighttime Cold and Flu Maximum Strength CVS Pharmacy 2019-11-29
69842-0908-24 1 KIT in 1 KIT (69842-908-24) * 16 BLISTER PACK in 1 CARTO... Daytime Nighttime Sinus Relief Maximum Strength CVS Pharmacy 2019-10-30
70692-0837-84 48 CAPSULE, LIQUID FILLED in 1 BOTTLE (70692-837-84) RIGHT REMEDIES NIGHTTIME SEVERE COLD AND FLU softgel Strive Pharmaceuticals Inc. 2025-09-23
72476-0998-14 2 BLISTER PACK in 1 CARTON (72476-998-14) / 8 CAPSULE, LIQU... Night Time Cold and Flu Retail Business Services, LLC 2019-03-18
72854-0129-24 1 KIT in 1 CARTON (72854-129-24) * 8 CAPSULE, LIQUID FILLE... Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Maximum Strength Reckitt Benckiser LLC 2021-07-26
72854-0144-10 1 KIT in 1 CARTON (72854-144-10) * 6 CAPSULE, LIQUID FILLE... Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Maximum Strength Reckitt Benckiser LLC 2023-06-14
76162-0637-24 2 BLISTER PACK in 1 CARTON (76162-637-24) / 12 CAPSULE, LIQ... NiteTime SEVERE Cold and Flu Relief SOFTGELS Topco Associates LLC 2025-12-11
76162-0678-24 1 KIT in 1 CARTON (76162-678-24) * 12 CAPSULE, LIQUID FILL... COMBINATION PACK TopCare health DayTime SEVERE and NiteTime SEVERE Cold and Flu Relief SOFTGELS - 24 ct Topco Associates LLC 2025-12-11
76162-0679-24 1 KIT in 1 CARTON (76162-679-24) * 8 CAPSULE, LIQUID FILLE... MAXIMUM STRENGTH Sinus Relief Day and Night SOFTGELS - 24 ct Topco Associates LLC 2025-10-13
76162-0812-24 2 BLISTER PACK in 1 CARTON (76162-812-24) / 12 CAPSULE, LIQ... TopCare Nite Time SEVERE Cold and Flu Topco Associates LLC 2023-11-03
76162-0823-12 1 KIT in 1 CARTON (76162-823-12) * 12 CAPSULE, LIQUID FILL... Cold and Flu Severe Daytime/Nighttime Topco Associates LLC 2023-11-03
76162-0824-12 1 KIT in 1 CARTON (76162-824-12) * 8 CAPSULE, LIQUID FILLE... MAXIMUM STRENGTH Sinus Relief Topco Associates LLC 2023-12-25
79903-0133-20 1 KIT in 1 CARTON (79903-133-20) * 1 BLISTER PACK in 1 CAR... Equate Health Non Drowsy DAY Cold and Flu Plus and NIGHTTIME Cold and Flu Plus Wal-Mart Stores Inc 2022-08-11
79903-0134-24 2 BLISTER PACK in 1 CARTON (79903-134-24) / 12 CAPSULE, LIQ... NIGHTTIME SEVERE COLD AND FLU Wal-Mart Stores Inc 2022-08-04
79903-0315-20 1 KIT in 1 CARTON (79903-315-20) * 1 CAPSULE, LIQUID FILLE... Daytime Nighttime Cold and Flu Walmart Inc. 2025-03-01
79903-0383-16 2 BLISTER PACK in 1 CARTON (79903-383-16) / 1 KIT in 1 BLIS... Daytime Nighttime Cold and Flu Walmart Inc. 2025-07-15
79903-0387-24 2 BLISTER PACK in 1 CARTON (79903-387-24) / 12 CAPSULE, LIQ... equate MAXIMUM STRENGTH NIGHTTIME SEVERE Cold and Flu SOFTGELS WALMART INC. 2025-09-10
83324-0038-24 2 BLISTER PACK in 1 CARTON (83324-038-24) / 12 CAPSULE, LIQ... QUALITY CHOICE NightTime Severe Cold and Flu Chain Drug Marketing Association, Inc. 2024-01-12
83324-0224-24 2 BLISTER PACK in 1 CARTON (83324-224-24) / 12 CAPSULE, LIQ... QUALITY CHOICE Maximum Strength Nighttime Cold and Flu Chain Drug Marketing Association, Inc. 2025-11-04
Observed labelers: Bayer HealthCare LLC. (23) · Walgreens (9) · The Procter & Gamble Manufacturing Company (7) · Topco Associates LLC (6) · Reckitt Benckiser LLC (4) · Bayer HealthCare, LLC. (3) · +18 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.