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Acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / guaifenesin 200 MG / phenylep... — RxCUI 1656815

RxNorm drug concept · Semantic clinical drug
RxCUI 1656815 Semantic clinical drug · SCD ● Current RxNorm concept 60 FDA products 76 package NDCs Snapshot Jul 14, 2026

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Compiled from public NLM RxNorm and FDA (openFDA NDC directory) data sources. Editorial policy

What you’re looking at: the standardized identity of one medicine, as the U.S. drug-data system sees it. Below — every FDA-listed product, package code, price benchmark, and billing code that maps to it.

🗂️ Key Facts

RxCUI1656815
Official nameAcetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / guaifenesin 200 MG / phenylephrine hydrochloride 5 MG Oral Capsule
Concept typeSemantic clinical drug (SCD)
RxNorm statusCurrent RxNorm concept
Also known asAPAP 325 MG / Dextromethorphan Hydrobromide 10 MG / Guaifenesin 200 MG / Phenylephrine Hydrochloride 5 MG Oral Capsule; acetaminophen 325 MG / dextromethorphan HBr 10 MG / guaiFENesin 200 MG / phenylephrine HCl 5 MG Oral Capsule
FDA products mapped60
Package NDCs mapped76
RxNorm release07/06/2026
Snapshot dataJul 14, 2026

📖 Skip the Codes — Read It in Plain English.

Our pharmacist-built guide to Phenylephrine: what it is, how it’s used, side effects, and interactions.

📗 Our plain-language guide HelloPharmacist
  • Yes, it's the same active ingredient, but used in very different ways depending on the form. The nasal spray delivers a tiny amount directly to the nasal lining to temporarily shri...
  • I see phenylephrine in nasal sprays at the pharmacy AND as an IV drug in the hospital — is it really the same medication?
  • You should check with your doctor first. Phenylephrine constricts blood vessels, which can raise blood pressure and put extra strain on the heart — even from a nasal spray. If you...
  • Can I use the nasal spray if I have high blood pressure or heart disease?
📖 Read our full Phenylephrine guide →

🕸️ Concept Web — How Acetaminophen 325 MG / dextromethorphan hydrobro... Connects

One RxCUI never lives alone. Follow the path from the raw ingredient down to the exact strength-and-form concepts FDA products carry — every stop is a real RxNorm concept with its own identifier. Hover or focus any chip for what it means.
This page's concept Acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / guaifenesin 200 MG / phenylephrine hydrochloride 5 MG Oral Capsule RxCUI 1656815

Every web starts here: one RxCUI, one fixed meaning in the RxNorm vocabulary.

  1. Ingredients 7

    The active substance itself — no strength, form, or brand attached yet.

    • Acetaminophen 161
    • Dextromethorphan 3289
    • Guaifenesin 5032
    • Phenylephrine 8163
    • Acetaminophen / dextromethorphan / guaifenesin / phenylephrine 689776
    • Dextromethorphan hydrobromide 102490
    • Phenylephrine hydrochloride 8164
  2. Dose forms 9

    The ingredient poured into a form — tablet, solution, cream — still without one fixed strength.

    • Acetaminophen / dextromethorphan / guaifenesin / phenylephrine Oral Capsule 1145621
    • Acetaminophen / dextromethorphan hydrobromide / guaifenesin / phenylephrine hydrochloride Oral Capsule 2648118
    • Acetaminophen / dextromethorphan / guaifenesin / phenylephrine Oral Product 1155905
    • Acetaminophen / dextromethorphan / guaifenesin / phenylephrine Pill 1155906
    • Acetaminophen / dextromethorphan hydrobromide / guaifenesin / phenylephrine hydrochloride Oral Product 2662312
    • Acetaminophen / dextromethorphan hydrobromide / guaifenesin / phenylephrine hydrochloride Pill 2659957
    • Oral Capsule 316965
    • Oral Product 1151131
    • +1 more in this family
  3. Clinical & branded drugs 4

    Ingredient + strength + dose form. These are the concepts real FDA products actually carry.

    • Acetaminophen 325 MG 315263
    • Dextromethorphan hydrobromide 10 MG 1014455
    • Guaifenesin 200 MG 317384
    • Phenylephrine hydrochloride 5 MG 1020198
  4. Packs 1

    Fixed collections of drugs packaged and sold together, like dose packs.

Showing up to 8 concepts per family — 20 of 21 stored related concepts drawn.
These are official RxNorm vocabulary relationships — how concepts name and organize the same medicine. They do not establish therapeutic equivalence or substitutability: two concepts appearing in one web is never a statement that products can be swapped.

🔀 Generic ⇄ Brand Crosswalk

The same medicine has an unbranded (generic) identity and one or more brand-name identities — each with its own RxCUI. This is a naming relationship in RxNorm, not a statement that any two products are substitutable.

Generic (Clinical) Concepts

📦 FDA Products & Package NDCs

60 products · 76 package NDCs
76 package NDCs map to RxCUI 1656815 in the current snapshot — up to 50 per page. Each linked NDC opens its full package page.
Package NDC Package Brand / generic name Labeler Marketing start
00280-0035-01 1 KIT in 1 CARTON (0280-0035-01) * 3 CAPSULE, LIQUID FILLE... Alka-Seltzer Plus Cough, Mucus and Congestion Day and Night Powermax Bayer HealthCare LLC. 2020-06-01
00280-0061-01 2 BLISTER PACK in 1 CARTON (0280-0061-01) / 8 CAPSULE, LIQU... Alka-Seltzer Plus Maximum Strength Cough, Mucus and Congestion Powermax Bayer HealthCare LLC. 2020-06-01
00280-0061-02 2 BLISTER PACK in 1 CARTON (0280-0061-02) / 12 CAPSULE, LIQ... Alka-Seltzer Plus Maximum Strength Cough, Mucus and Congestion Powermax Bayer HealthCare LLC. 2020-06-01
00280-0062-01 1 KIT in 1 CARTON (0280-0062-01) * 2 CAPSULE, LIQUID FILLE... Alka-Seltzer Plus Maximum Strength Cough, Mucus and Congestion Day and Night Bayer HealthCare, LLC. 2020-06-01
00280-8286-16 1 KIT in 1 CARTON (0280-8286-16) * 1 CAPSULE, LIQUID FILLE... ALKA SELTZER COLD Cold Mucus and Congestion Maximum Strength Day Night Fast Gels Bayer HealthCare, LLC. 2026-06-01
00280-8286-24 1 KIT in 1 CARTON (0280-8286-24) * 1 CAPSULE, LIQUID FILLE... ALKA SELTZER COLD Cold Mucus and Congestion Maximum Strength Day Night Fast Gels Bayer HealthCare, LLC. 2026-06-01
00280-8294-24 3 BLISTER PACK in 1 CARTON (0280-8294-24) / 8 CAPSULE, LIQU... Alka Seltzer COLD Cold Mucus Congestion Maximum Strength Fast Gels Bayer HealthCare LLC. 2026-06-01
00363-0109-24 2 BLISTER PACK in 1 CARTON (0363-0109-24) / 12 CAPSULE, LIQ... DAYTIME COLD AND FLU Maximum Strength Walgreens 2022-06-23
00363-0744-24 3 BLISTER PACK in 1 CARTON (0363-0744-24) / 1 KIT in 1 BLIS... Daytime Nighttime Sinus Relief Maximum Strength Walgreens 2022-06-01
00363-0746-24 3 BLISTER PACK in 1 CARTON (0363-0746-24) / 1 KIT in 1 BLIS... DAYTIME NIGHTTIME SEVERE COLD AND FLU Maximum Strength Walgreens 2022-06-01
00363-0746-48 6 BLISTER PACK in 1 CARTON (0363-0746-48) / 1 KIT in 1 BLIS... DAYTIME NIGHTTIME SEVERE COLD AND FLU Maximum Strength Walgreens 2022-06-01
00363-0775-24 3 BLISTER PACK in 1 CARTON (0363-0775-24) / 1 KIT in 1 BLIS... Daytime and Nighttime Cold and Flu Maximum Strength Walgreens 2022-06-01
00363-8995-24 1 KIT in 1 PACKAGE, COMBINATION (0363-8995-24) * 8 CAPSULE... SEVERE COLD AND FLU DAYTIME NON DROWSY and NIGHTTIME Walgreens 2021-08-23
00363-8996-24 2 BLISTER PACK in 1 CARTON (0363-8996-24) / 12 CAPSULE, LIQ... SEVERE DAYTIME COLD and FLU DAYTIME MAXIMUM STRENGTH NON-DROWSY SEVERE Walgreens 2021-08-23
00363-9016-16 2 BLISTER PACK in 1 CARTON (0363-9016-16) / 8 CAPSULE, LIQU... COLD, Flu and Sore Throat Walgreens 2021-08-24
00363-9017-16 2 BLISTER PACK in 1 CARTON (0363-9017-16) / 8 CAPSULE, LIQU... Maximum Strength Cold and Flu Walgreens 2021-08-24
11673-0972-16 16 CAPSULE, LIQUID FILLED in 1 BLISTER PACK (11673-972-16) COLD AND FLU DAYTIME SEVERE TARGET CORP 2020-05-29
11673-0972-24 24 CAPSULE, LIQUID FILLED in 1 BLISTER PACK (11673-972-24) COLD AND FLU DAYTIME SEVERE TARGET CORP 2020-05-29
11673-0978-16 2 BLISTER PACK in 1 CARTON (11673-978-16) / 8 CAPSULE, LIQU... MAXIMUM STRENGTH COLD AND FLU TARGET CORP 2020-06-08
11673-0984-24 24 BLISTER PACK in 1 CARTON (11673-984-24) / 1 KIT in 1 BLI... COLD AND FLU DAYTIME-NIGHTTIME TARGET CORP 2020-06-03
35916-0166-01 2 BLISTER PACK in 1 CARTON (35916-0166-1) / 12 CAPSULE, LIQ... Acetaminophen, Guaifenesin, Phenylephrine Hcl and Dextromethorphan HBr Softgel Healthcare Pvt Ltd 2024-10-29
37000-0517-02 2 CAPSULE, LIQUID FILLED in 1 POUCH (37000-517-02) Vicks DayQuil Severe Cold and Flu The Procter & Gamble Manufacturing Company 2021-01-01
37000-0517-08 1 BLISTER PACK in 1 CARTON (37000-517-08) / 8 CAPSULE, LIQU... Vicks DayQuil Severe Cold and Flu The Procter & Gamble Manufacturing Company 2019-07-01
37000-0517-16 2 BLISTER PACK in 1 CARTON (37000-517-16) / 8 CAPSULE, LIQU... Vicks DayQuil Severe Cold and Flu The Procter & Gamble Manufacturing Company 2018-07-10
37000-0517-24 2 BLISTER PACK in 1 CARTON (37000-517-24) / 12 CAPSULE, LIQ... Vicks DayQuil Severe Cold and Flu The Procter & Gamble Manufacturing Company 2018-07-10
37000-0934-12 1 KIT in 1 PACKAGE (37000-934-12) * 1 BLISTER PACK in 1 CA... Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu The Procter & Gamble Manufacturing Company 2019-07-04
37000-0934-24 1 KIT in 1 PACKAGE (37000-934-24) * 1 BLISTER PACK in 1 CA... Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu The Procter & Gamble Manufacturing Company 2019-07-04
37000-0934-48 1 KIT in 1 PACKAGE (37000-934-48) * 1 BLISTER PACK in 1 CA... Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu The Procter & Gamble Manufacturing Company 2019-07-04
37000-0934-72 1 KIT in 1 PACKAGE (37000-934-72) * 1 BLISTER PACK in 1 CA... Vicks DayQuil Severe and Vicks NyQuil Severe Cold and Flu The Procter & Gamble Manufacturing Company 2019-07-04
41226-0625-24 2 BLISTER PACK in 1 CARTON (41226-625-24) / 12 CAPSULE, LIQ... DAYTIME SEVERE COLD AND FLU KROGER COMPANY 2020-05-29
41226-0627-24 24 BLISTER PACK in 1 CARTON (41226-627-24) / 1 KIT in 1 BLI... DAYTIME-NIGHTTIME SEVERE COLD AND FLU KROGER 2020-06-03
41226-0628-16 16 CAPSULE, LIQUID FILLED in 1 BLISTER PACK (41226-628-16) ACETAMINOPHEN, DEXTROMETHORPHAN HBr, GUAILFENESIN,PHENLYEPHRINE HCL Kroger Company 2020-12-21
41520-0984-14 2 BLISTER PACK in 1 CARTON (41520-984-14) / 8 CAPSULE, LIQU... COLD FLU and SORE THROAT RELIEF FOODHOLD U.S.A., LLC 2016-10-05
41520-0985-14 2 BLISTER PACK in 1 CARTON (41520-985-14) / 8 CAPSULE, LIQU... Severe sinus Congestion Relief FOODHOLD U.S.A., LLC 2016-10-06
49035-0586-04 1 KIT in 1 CARTON (49035-586-04) * 2 BLISTER PACK in 1 CAR... Day Severe Cold and Night Cold and Flu Maximum Strength Wal-Mart Stores, Inc. 2018-01-31
49035-0587-04 1 KIT in 1 CARTON (49035-587-04) * 2 BLISTER PACK in 1 CAR... Day and Night Sinus Relief Maximum Strength Wal-Mart Stores, Inc. 2018-01-31
51013-0174-04 2 BLISTER PACK in 1 CARTON (51013-174-04) / 12 CAPSULE, LIQ... Daytime Severe Cold and Flu Relief PuraCap Pharmaceutical LLC 2016-06-13
51316-0525-24 2 BLISTER PACK in 1 CARTON (51316-525-24) / 12 CAPSULE in 1... DAYTIME SEVERE COLD AND FLU CVS HEALTH CORP 2025-02-01
51316-0527-24 2 BLISTER PACK in 1 CARTON (51316-527-24) / 1 KIT in 1 BLIS... Daytime Nighttime Severe Cold and Flu CVS HEALTH CORP 2025-02-01
51316-0527-48 4 BLISTER PACK in 1 CARTON (51316-527-48) / 1 KIT in 1 BLIS... Daytime Nighttime Severe Cold and Flu CVS HEALTH CORP 2025-02-01
53345-0021-01 1 BAG in 1 BOX (53345-021-01) / 3000 CAPSULE, LIQUID FILLED... Daytime Severe Cold and Flu Humanwell PuraCap Pharmaceutical (Wuhan), Ltd. 2014-07-11
55319-0628-16 16 CAPSULE, LIQUID FILLED in 1 BLISTER PACK (55319-628-16) MAXIMUM STRENGTH COLD AND FLU FAMILY DOLLAR SERVICES 2020-08-24
63824-0518-08 1 BLISTER PACK in 1 CARTON (63824-518-08) / 8 CAPSULE, LIQU... Maximum Strength Mucinex Fast-Max Cold and Flu Reckitt Benckiser LLC 2020-06-01
63824-0518-16 2 BLISTER PACK in 1 CARTON (63824-518-16) / 8 CAPSULE, LIQU... Maximum Strength Mucinex Fast-Max Cold and Flu Reckitt Benckiser LLC 2018-07-28
63824-0519-24 1 KIT in 1 CARTON (63824-519-24) / 1 KIT in 1 KIT * 8 CAPS... Maximum Strength Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Reckitt Benckiser LLC 2018-07-28
63824-0519-48 2 KIT in 1 CARTON (63824-519-48) / 1 KIT in 1 KIT * 8 CAPS... Maximum Strength Mucinex Fast-Max Day Cold and Flu and Night Cold and Flu Reckitt Benckiser LLC 2018-07-28
63824-0591-16 2 BLISTER PACK in 1 CARTON (63824-591-16) / 8 CAPSULE, LIQU... Mucinex Fast-Max Cold, Flu and Sore Throat Reckitt Benckiser LLC 2015-07-15
63824-0693-08 1 BLISTER PACK in 1 CARTON (63824-693-08) / 8 CAPSULE, LIQU... Mucinex Sinus-Max Pressure, Pain and Cough Reckitt Benckiser LLC 2020-06-01
63824-0693-16 2 BLISTER PACK in 1 CARTON (63824-693-16) / 8 CAPSULE, LIQU... Mucinex Sinus-Max Pressure, Pain and Cough Reckitt Benckiser LLC 2017-07-01
69729-0782-10 10 CAPSULE, LIQUID FILLED in 1 BLISTER PACK (69729-782-10) Acetaminophen, Guaifenesin, Dextromethorphan HBr, Phenylephrine HCl OPMX LLC 2019-02-18
Observed labelers: Reckitt Benckiser LLC (14) · Walgreens (9) · The Procter & Gamble Manufacturing Company (8) · Topco Associates LLC (6) · Bayer HealthCare LLC. (4) · CVS Pharmacy (4) · +18 more — this is the FDA-listed mapping footprint, not sales, inventory, availability, or market share.

🗃️ Sources & Limits

Atlas generation902fddb9-e9c1-4004-bf4c-dba4d51037c7
openFDA export observedJul 14, 2026
RxNorm release07/06/2026
Methodology2026-07-full-catalog-v1
  • A shared RxCUI does not prove interchangeability. Products mapped to the same concept are not thereby equivalent or substitutable — equivalence is a separate, product-level determination.
  • Listing here does not establish approval or coverage. Appearing in this snapshot is a data observation, not an FDA approval status or a payer coverage decision.
  • Missing data never means zero. A silent dataset (no price, no billing code, no utilization) means no observation — not that the real-world value is zero.
  • Counts describe the mapping footprint. Product, package, and labeler counts are the FDA-listed mapping footprint in this snapshot — not sales, inventory, availability, or market share.
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.

Machine-readable JSON

Reference information about drug-concept identifiers and public regulatory data — not medical advice. Talk to your pharmacist or prescriber about your own medication.