Allopurinol

32 interactions 333 cited references
Also sold as: Aloprim Lopurin® Zyloprim Zyloprim®
About Allopurinol

Allopurinol is used to treat gout (a type of arthritis in which uric acid, a naturally occurring substance in the body, builds up in the joints and causes sudden attacks of redness, swelling, pain, and heat in one or more joints). Allopurinol is also used to treat high levels of uric acid that builds up in the blood as… Read the full Allopurinol drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 12, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Didanosine Fezolinetant Acenocoumarol Azathioprine Capecitabine Pegloticase Injection
2 Contraindicated 22 Major 7 Moderate 1 Minor
All (32) Contraindicated (2) Major (22) Moderate (7) Minor (1)

Contraindicated

Allopurinol Didanosine Videx® Increased serum concentrations of didanosine Details Allopurinol Fezolinetant Increased fezolinetant exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.