Cefixime

27 interactions 114 cited references
Also sold as: Suprax Suprax®
About Cefixime

Cefixime is used to treat certain infections caused by bacteria such as bronchitis (infection of the airway tubes leading to the lungs); gonorrhea (a sexually transmitted disease); and infections of the ears, throat, tonsils, and urinary tract. Cefixime is in a class of medications called cephalosporin antibiotics. It… Read the full Cefixime drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Methotrexate Injection Levonorgestrel Intrauterine System Furosemide Injection Exenatide Injection Estradiol Transdermal Patch Estradiol Topical
24 Major 3 Moderate
All (27) Major (24) Moderate (3)

Major

Cefixime Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Cefixime Desogestrel Decreased contraceptive effectiveness Details Cefixime Dienogest Decreased contraceptive effectiveness Details Cefixime Drospirenone Decreased contraceptive effectiveness Details Cefixime Estradiol Delestrogen Decreased contraceptive effectiveness Details Cefixime Ethinyl Estradiol Decreased contraceptive effectiveness Details Cefixime Ethynodiol Decreased contraceptive effectiveness Details Cefixime Exenatide Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Cefixime Furosemide Disal Increased risk of cephalosporin-induced nephrotoxicity Details Cefixime Gestodene Decreased contraceptive effectiveness Details Cefixime Levonorgestrel After banger Decreased contraceptive effectiveness Details Cefixime Mestranol Decreased contraceptive effectiveness Details Cefixime Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Cefixime Nomegestrol Decreased contraceptive effectiveness Details Cefixime Norethindrone Aygestin Decreased contraceptive effectiveness Details Cefixime Norgestimate Decreased contraceptive effectiveness Details Cefixime Norgestrel Decreased contraceptive effectiveness Details Cefixime Warfarin Coumadin An increased risk of bleeding Details Cefixime Estradiol Topical Divigel Decreased contraceptive effectiveness Details Cefixime Estradiol Transdermal Patch Alora® Decreased contraceptive effectiveness Details Cefixime Exenatide Injection Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Cefixime Furosemide Injection Disal Increased risk of cephalosporin-induced nephrotoxicity Details Cefixime Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details Cefixime Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Moderate

Cefixime Lixisenatide Delayed therapeutic effect Details Cefixime Typhoid Vaccine, Live Vivotif A decreased immunological response to the typhoid vaccine Details Cefixime Lixisenatide Injection Adlyxin® Delayed therapeutic effect Details

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