Dantrolene

21 interactions 2 explained in plain English
Also sold as: Dantrium Revonto Ryanodex
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Methotrexate Injection Buprenorphine Azathioprine Fentanyl Transdermal Patch Nisoldipine Hydromorphone Rectal
21 Major
All (21) Major (21)

Major

Dantrolene Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory depression Details Dantrolene Buprenorphine Belbuca Explained Enhanced neuromuscular blocking action and an increased risk of respiratory depression and CNS depression Details Dantrolene Azathioprine Azasan An increased risk of hepatotoxicity Details Dantrolene Amlodipine Amvaz® Severe hyperkalemia with cardiovascular collapse Details Dantrolene Diazepam Nasal Spray Valtoco Additive respiratory depression Details Dantrolene Diazepam Rectal Diastat Additive respiratory depression Details Dantrolene Felodipine Plendil® Severe hyperkalemia with cardiovascular collapse Details Dantrolene Fentanyl Transdermal Patch Duragesic® An increased risk of respiratory depression Details Dantrolene Hydromorphone Injection Dilaudid Increased risk of respiratory depression Details Dantrolene Hydromorphone Rectal available generically Increased risk of respiratory depression Details Dantrolene Isradipine DynaCirc® Severe hyperkalemia with cardiovascular collapse Details Dantrolene Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Dantrolene Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate toxicity or methotrexate-related severe adverse reactions, redu... Details Dantrolene Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate toxicity or methotrexate-related severe adverse reactions, redu... Details Dantrolene Midazolam Nasal Spray Nayzilam Additive respiratory depression Details Dantrolene Midazolam Injection Nayzilam Additive respiratory depression Details Dantrolene Morphine Injection Astramorph® PF Increased degree of respiratory depression Details Dantrolene Nicardipine Cardene Severe hyperkalemia with cardiovascular collapse Details Dantrolene Nifedipine Adalat® Severe hyperkalemia with cardiovascular collapse Details Dantrolene Nimodipine Nimotop Severe hyperkalemia with cardiovascular collapse Details Dantrolene Nisoldipine Sular Severe hyperkalemia with cardiovascular collapse Details

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