Deutetrabenazine

262 interactions 159 cited references
Also sold as: Austedo Austedo XR® Austedo®
About Deutetrabenazine

Deutetrabenazine is used to treat chorea (sudden movements that you cannot control) caused by Huntington's disease (an inherited disease that causes the progressive breakdown of nerve cells in the brain). It is also used to treat tardive dyskinesia (uncontrollable movement of the face, tongue, or other body parts). Deu… Read the full Deutetrabenazine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isocarboxazid Linezolid Levoketoconazole Iproniazid Mesoridazine Mavorixafor
29 Contraindicated 233 Major
All (262) Contraindicated (29) Major (233)

Contraindicated

Deutetrabenazine Bepridil An increased risk of QT interval prolongation Details Deutetrabenazine Cisapride Propulsid® Increased risk of QT interval prolongation Details Deutetrabenazine Dronedarone Multaq Increased risk of QT interval prolongation Details Deutetrabenazine Furazolidone Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Deutetrabenazine Iproniazid Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Deutetrabenazine Isocarboxazid Marplan Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Deutetrabenazine Levoketoconazole Recorlev An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Deutetrabenazine Linezolid Zyvox Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Deutetrabenazine Mavorixafor Xolremdi Increased CYP2D6 substrate exposure, increased risk of CYP2D6-related adverse events and an increased risk of QT interval prolonga... Details Deutetrabenazine Mesoridazine An increased risk of QT interval prolongation Details Deutetrabenazine Methylene Blue Provayblue Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Deutetrabenazine Moclobemide Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Deutetrabenazine Nialamide Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Deutetrabenazine Phenelzine Nardil Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Deutetrabenazine Pimozide An increased risk of QT interval prolongation Details Deutetrabenazine Piperaquine An increased risk of QT interval prolongation Details Deutetrabenazine Procarbazine Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Deutetrabenazine Rasagiline Azilect Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Deutetrabenazine Reserpine Serpalan® Depletion of serotonin and norepinephrine in the central nervous system Details Deutetrabenazine Safinamide Xadago Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Deutetrabenazine Saquinavir An increased risk of QT interval prolongation Details Deutetrabenazine Selegiline Anipryl Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Deutetrabenazine Sparfloxacin An increased risk of QT interval prolongation Details Deutetrabenazine Terfenadine An increased risk of QT interval prolongation Details Deutetrabenazine Tetrabenazine Xenazine Depletion of monoamines in the central nervous system Details Deutetrabenazine Thioridazine An increased risk of QT interval prolongation Details Deutetrabenazine Tranylcypromine Parnate Hypertensive crisis (headache, hyperpyrexia, hypertension) Details Deutetrabenazine Ziprasidone Geodon An increased risk of QT interval prolongation Details Deutetrabenazine Linezolid Injection Zyvox Hypertensive crisis (headache, hyperpyrexia, hypertension) Details

Major

Deutetrabenazine Amitriptyline Elavil An increased risk of QT interval prolongation Details Deutetrabenazine Sertraline Increased risk of QT interval prolongation and an increased CYP2D6 substrate exposure Details Deutetrabenazine Buprenorphine Belbuca An increased risk of QT interval prolongation Details Deutetrabenazine Relugolix Orgovyx Increased risk of QT interval prolongation Details Deutetrabenazine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Deutetrabenazine Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Deutetrabenazine Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Deutetrabenazine Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation Details Deutetrabenazine Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation Details Deutetrabenazine Azithromycin AzaSite An increased risk of QT interval prolongation Details Deutetrabenazine Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.