Drospirenone

48 interactions 2 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Colesevelam Penicillin G Procaine Injection Lixisenatide Injection Cyclosporine Ophthalmic Octreotide Injection Penicillin V Potassium

42 Major 6 Moderate

All (48) Major (42) Moderate (6)

Major

Drospirenone Isotretinoin Absorica Explained Decreased effectiveness of hormonal contraceptives Details Drospirenone Amoxicillin Amoxi Drop Reduced efficacy of oral contraceptive Details Drospirenone Ampicillin Amcill® Decreased contraceptive effectiveness Details Drospirenone Ampicillin Injection Omnipen-N® Decreased contraceptive effectiveness Details Drospirenone Bexarotene Targretin Decreased contraceptive effectiveness Details Drospirenone Bexarotene Topical Targretin Decreased contraceptive effectiveness Details Drospirenone Cefaclor Ceclor® Decreased contraceptive effectiveness Details Drospirenone Cefadroxil Duricef® Decreased contraceptive effectiveness Details Drospirenone Cefdinir Omnicef® Decreased contraceptive effectiveness Details Drospirenone Cefixime Suprax Decreased contraceptive effectiveness Details Drospirenone Cefprozil Cefzil® Decreased contraceptive effectiveness Details Drospirenone Ceftazidime Injection Fortaz Decreased contraceptive effectiveness Details Drospirenone Cefuroxime Injection Kefurox® Decreased contraceptive effectiveness Details Drospirenone Colesevelam Welchol Decreased contraceptive effectiveness Details Drospirenone Cyclosporine Injection Atopica Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Drospirenone Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Drospirenone Dexamethasone Injection Decadron Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Drospirenone Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Drospirenone Doxycycline Injection Acticlate Reduced efficacy of oral contraceptive Details Drospirenone Enasidenib Idhifa Reduced hormonal contraceptive exposure and reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleed... Details Drospirenone Encorafenib Braftovi Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Drospirenone Exenatide Injection Bydureon Reduced oral contraceptives absorption and reduced efficacy of oral contraceptives Details Drospirenone Felbamate Felbatol Reduced drospirenone/ethinyl estradiol exposure and an increased risk of breakthrough bleeding/contraceptive failure Details Drospirenone Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Drospirenone Hydrocortisone Ala-Cort Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Drospirenone Hydrocortisone Injection A-Hydrocort® Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Drospirenone Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Drospirenone Lixisenatide Injection Adlyxin® Decreased absorption of oral contraceptives Details Drospirenone Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Drospirenone Meropenem Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Drospirenone Meropenem Injection Merrem® Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Drospirenone Methylergonovine Methergine Increased methylergonovine exposure Details Drospirenone Minocycline Amzeeq Decreased contraceptive efficacy Details Drospirenone Minocycline Topical Amzeeq Decreased contraceptive efficacy Details Drospirenone Mitapivat Aqvesme Reduced hormonal contraceptive exposure Details Drospirenone Nafcillin Injection Unipen® Injection Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Drospirenone Nevirapine Viramune Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Drospirenone Nifedipine Adalat® Increased NIFEdipine exposure Details Drospirenone Octreotide Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Drospirenone Octreotide Injection Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details

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