Feprazone and Lisinopril: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Lisinopril
Feprazone
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
Feprazone is an NSAID (a pain and inflammation medicine), and lisinopril is a blood pressure medicine. When you take them together, the NSAID can make your lisinopril work less well, so your blood pressure may creep up. Both drugs also lean on your kidneys, and using them together can put extra strain there, especially if you are older, dehydrated, or already have kidney trouble.
The good news is this is very manageable. Keep taking both exactly as prescribed and stay well hydrated. Your care team can check your blood pressure and run simple kidney blood tests to make sure everything stays on track. Talk with your pharmacist or doctor if you have questions.
Effect: Feprazone (an NSAID) may reduce the antihypertensive and natriuretic effect of lisinopril (ACE inhibitor) and can additively impair renal function, including possible acute renal failure.
Mechanism: NSAID inhibition of renal prostaglandin synthesis reduces afferent arteriolar vasodilation; combined with ACE inhibitor efferent effects, this can compromise glomerular perfusion and blunt natriuresis/BP control.
- Direction: reduced lisinopril efficacy; increased renal risk
- Onset: unspecified; Evidence: established
- Monitor: BP for efficacy; renal function (SCr, eGFR) at initiation and periodically
- Higher risk: elderly, volume-depleted, preexisting renal impairment
Ensure adequate hydration. Dose may need individualization by the care team.
What happens
Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure
Interaction Deep Dive
The blood pressure lowering and natriuretic actions of ACE inhibitors or angiotensin receptor blockers (ARBs) can be reduced by NSAIDs. Using these agents together may also worsen renal function in certain patients, potentially causing acute renal failure. If the combination cannot be avoided, evaluate whether renal function should be checked when therapy begins, watch for adequate antihypertensive response, and periodically test renal function to detect any renal deterioration or failure. This is particularly important in elderly patients, at the start of treatment, in those who are volume-depleted, or in individuals with existing renal impairment. Confirm that patients maintain adequate hydration1234.
Why it happens (mechanism)
Additive effects on renal function; decreased renal prostaglandin production
How to manage this interaction
This combination can be used when needed, but your care team will keep a closer eye on things.
- Keep taking both as prescribed unless your prescriber tells you otherwise.
- Your team may check your blood pressure to confirm the lisinopril is still working well.
- They may monitor your kidney function with blood tests at the start and periodically, especially if you are older, dehydrated, or have kidney concerns.
- Stay well hydrated.
Tell your pharmacist or doctor if your blood pressure readings rise, or if you notice less urination, swelling, or unusual tiredness. Doses can be adjusted and individualized by your care team.
Management is individual — confirm any change with your pharmacist or prescriber.
Literature reports
4 reports — tap to read
a) A 48-year-old man with hypertension that had previously been well managed on enalapril 10 mg/day developed severe hypertension, psychosis, disorientation, and generalized anasarca four days after beginning indomethacin 100 mg/day for gout 5. Raising the enalapril dose to 20 mg/day failed to control the hypertension, so indomethacin was stopped. The next day, the patient underwent rapid diuresis and considerable weight loss. The enalapril dose was subsequently lowered back to 10 mg/day, achieving good blood pressure control with no lasting psychosis 6.
b) In a randomized, double-blind, parallel-design multicenter study of 141 hypertensive patients, indomethacin opposed the antihypertensive action of captopril. After one week of combined indomethacin and captopril therapy, 24-hour systolic blood pressure rose by 4.6 mmHg and diastolic by 2.7 mmHg (p less than 0.001). In total, ambulatory diastolic blood pressure increased in 67% of patients receiving captopril while on indomethacin 7.
c) A 59-year-old man who had been treated for 5 years with lisinopril 10 mg/day experienced worsening hypertension after rofecoxib 25/day was started for arthritic pain. Following 5 weeks, blood pressure rose from 130 to 135/80 to 85 to 168/98. Rofecoxib was stopped. Blood pressure fell over the subsequent 18 days (average, 127/78 mmHg). Because of increased joint pain, rofecoxib was resumed at 25 mg/day. After 2 days of treatment, blood pressure increased, and over the following 2 weeks it averaged 143/89 mmHg. Lisinopril was raised to 20 mg/day, producing an average blood pressure of 121/81 mmHg over the next 21 days 8.
d) Celecoxib did not diminish the antihypertensive effect of lisinopril in 178 hypertensive patients in a double-blind, placebo-controlled, parallel-group trial. Patients received either celecoxib 200 mg twice daily or placebo in addition to their usual lisinopril regimen (10 to 40 mg daily) for 4 weeks. Changes from baseline in the 24-hour systolic and diastolic blood pressure (BP) were nonsignificant. The proportion of patients whose 24-hour BP rose by at least 5, 10, 15, or 20 mmHg was likewise comparable between celecoxib and placebo. The placebo-subtracted changes seen in 24-hour BP (1.6/1.2 mmHg) were smaller than what has been reported for NSAIDs in ACE inhibitor-treated patients 9.
Common questions
Can I take Feprazone and Lisinopril together?
Feprazone can weaken lisinopril's blood pressure control and stress your kidneys, so stay hydrated and let your care team monitor your blood pressure and kidney function while you use both. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Feprazone and Lisinopril interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Feprazone and Lisinopril interaction managed?
This combination can be used when needed, but your care team will keep a closer eye on things. Keep taking both as prescribed unless your prescriber tells you otherwise. Your team may check your blood pressure to confirm the lisinopril is still working well. They may monitor your kidney function with blood tests at the start and periodically, especially if you are older, dehydrated, or have kidney… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Feprazone or Lisinopril need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (9)
- Product Information: Dynastat intravenous injection, intramuscular injection, parecoxib sodium intravenous injection, intramuscular injection. Pfizer Australia Pty Ltd (per Australian Register of Therapeutic Goods), West Ryde, Australia, 2017. DailyMed
- Product Information: SPRIX(R) nasal spray, ketorolac tromethamine nasal spray. Egalet US Inc. (per FDA), Wayne, PA, 2016. DailyMed
- Product Information: CALDOLOR(R) intravenous injection, ibuprofen intravenous injection. Cumberland Pharmaceuticals Inc. (per FDA), Nashville, TN, 2016. DailyMed
- Product Information: meloxicam oral tablets, meloxicam oral tablets. Apotex Corp. (per DailyMed), Weston, FL, 2016. DailyMed
- Ahmad S: Indomethacin-enalapril interaction: an alert (letter). South Med J 1991; 84:411-412. PubMed
- Morgan T, Anderson A, & Bertram D: Effect of indomethacin on blood pressure in elderly people with essential hypertension well controlled on amlodipine or enalapril. Am J Hypertens 2000; 13:1161-1167. PubMed
- Conlin P, Moore T, Swartz S, et al: Effect of indomethacin on blood pressure lowering by captopril and losartan in hypertensive patients. Hypertension 2000; 36:461-465. PubMed
- Brown C: Effect of rofecoxib on the antihypertensive activity of lisinopril (letter). Ann Pharmacother 2000; 34:1486. PubMed
- White W, Kent J, Taylor A, et al: Effects of celecoxib on ambulatory blood pressure in hypertensive patients on ACE inhibitors. Hypertension 2002; 39:929-934. PubMed
Keep reading about Lisinopril
Keep reading about Feprazone
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