Flucloxacillin

Name: Flucloxacillin Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

12 interactions 1 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Acetaminophen Acetaminophen Injection Acetaminophen Rectal Hydroxychloroquine Methotrexate

7 Major 5 Minor

All (12) Major (7) Minor (5)

Major

Flucloxacillin Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of high anion gap metabolic acidosis (HAGMA) Details Flucloxacillin Acetaminophen Acephen An increased risk of high anion gap metabolic acidosis (HAGMA) Details Flucloxacillin Acetaminophen Injection Acephen An increased risk of high anion gap metabolic acidosis (HAGMA) Details Flucloxacillin Acetaminophen Rectal Acephen An increased risk of high anion gap metabolic acidosis (HAGMA) Details Flucloxacillin Hydroxychloroquine Plaquenil An increased risk of seizures Details Flucloxacillin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Flucloxacillin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Minor

Flucloxacillin Amikacin Injection Amikin® Loss of aminoglycoside efficacy Details Flucloxacillin Amikacin Oral Inhalation Arikayce Loss of aminoglycoside efficacy Details Flucloxacillin Gentamicin Injection Garamycin® I.V. Loss of aminoglycoside efficacy Details Flucloxacillin Gentamicin Ophthalmic Garamycin® Ophthalmic Loss of aminoglycoside efficacy Details Flucloxacillin Gentamicin Topical Garamycin® Loss of aminoglycoside efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.