Glycopyrrolate and Digoxin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Glycopyrrolate
Digoxin
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased plasma concentrations of digoxin
Interaction Deep Dive
Glycopyrrolate reduces gastrointestinal transit time. Concomitant use of glycopyrrolate and digoxin tablets may result in increased plasma concentrations of digoxin. Monitor increased digoxin effects if glycopyrrolate is coadministered with digoxin. Consider using other oral digoxin dosage form such as liquid or capsule1.
Why it happens (mechanism)
Altered release of digoxin slow dissolution oral tablets due to reduced gastrointestinal transit time by glycopyrrolate
Common questions
Can I take Glycopyrrolate and Digoxin together?
Increased plasma concentrations of digoxin Always confirm with your pharmacist or prescriber before making any change.
How serious is the Glycopyrrolate and Digoxin interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Glycopyrrolate or Digoxin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: CUVPOSA oral solution, glycopyrrolate oral solution. Shionogi Pharma Inc, Atlanta, GA, 2010. DailyMed
Keep reading about Glycopyrrolate
Keep reading about Digoxin
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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