Glycopyrrolate

21 interactions 4 explained in plain English
Also sold as: Cuvposa Dartisla Glycate Glyrx Lonhala Robinul
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Diphenhydramine Injection Amitriptyline Hydromorphone Rectal Trospium / Xanomeline Morphine Injection Glucagon Injection / Solution
20 Major 1 Moderate
All (21) Major (20) Moderate (1)

Major

Glycopyrrolate Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of paralytic ileus Details Glycopyrrolate Amitriptyline Elavil Explained An increased risk of anticholinergic side effects Details Glycopyrrolate Buprenorphine Belbuca Explained An increased risk of paralytic ileus Details Glycopyrrolate Trospium / Xanomeline Cobenfy Explained An increased risk of anticholinergic side effects Details Glycopyrrolate Aclidinium Oral Inhalation Tudorza An increased risk of anticholinergic side effects Details Glycopyrrolate Atropine Ophthalmic Atropine Care 1% An increased risk of anticholinergic side effects Details Glycopyrrolate Cyclopentolate Ophthalmic Akpentolate® An increased risk of anticholinergic side effects Details Glycopyrrolate Diphenhydramine Injection Banophen An increased risk of anticholinergic side effects Details Glycopyrrolate Diphenhydramine Topical Afterbite with Antihistamine An increased risk of anticholinergic side effects Details Glycopyrrolate Fentanyl Transdermal Patch Duragesic® Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Glycopyrrolate Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Glycopyrrolate Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Glycopyrrolate Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Glycopyrrolate Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Glycopyrrolate Hydromorphone Injection Dilaudid Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Glycopyrrolate Hydromorphone Rectal available generically Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Glycopyrrolate Hydroxychloroquine Plaquenil An increased risk of seizures Details Glycopyrrolate Ipratropium Nasal Spray Atrovent Nasal Spray® An increased risk of anticholinergic side effects Details Glycopyrrolate Ipratropium Oral Inhalation Atrovent® HFA An increased risk of anticholinergic side effects Details Glycopyrrolate Morphine Injection Astramorph® PF Increased risk of urinary retention, severe constipation, and paralytic ileus Details

Moderate

Glycopyrrolate Digoxin Cardoxin® Increased plasma concentrations of digoxin Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.