Heparin

221 interactions 919 cited references

Read the full Heparin drug information page

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Defibrotide Injection Defibrotide Telavancin Oritavancin Epoprostenol Omadacycline Injection
4 Contraindicated 169 Major 46 Moderate 2 Minor
All (221) Contraindicated (4) Major (169) Moderate (46) Minor (2)

Contraindicated

Heparin Defibrotide Injection Defitelio Increased risk of bleeding Details Heparin Defibrotide Increased risk of bleeding Details Heparin Oritavancin Falsely elevated aPTT test results Details Heparin Telavancin Vibativ Artificial prolongation of aPTT test results Details

Major

Heparin Sertraline An increased risk of bleeding Details Heparin Apixaban Eliquis An increased risk of bleeding and can cause serious, potentially fatal bleeding Details Heparin Aspirin Acuprin® Increased risk of bleeding Details Heparin Aspirin Rectal Aspirin Increased risk of bleeding Details Heparin Betrixaban Bevyxxa® Increased risk of bleeding Details Heparin Anagrelide Agrylin Increased risk of bleeding Details Heparin Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Heparin Caplacizumab-Yhdp Injection Cablivi An increased risk of bleeding Details Heparin Clopidogrel Plavix Increased risk of bleeding Details Heparin Dabigatran Pradaxa® An increased risk of bleeding Details Heparin Dabigatran Etexilate An increased risk of bleeding Details Heparin Dalteparin Injection Fragmin Increased risk of bleeding Details Heparin Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Heparin Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Heparin Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Heparin Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Heparin Dipyridamole Permole® Increased risk of bleeding Details Heparin Doxycycline Injection Acticlate An increased risk of bleeding Details Heparin Edoxaban Savaysa Increased risk of bleeding Details Heparin Enoxaparin Lovenox Increased risk of bleeding Details Heparin Enoxaparin Injection Lovenox Increased risk of bleeding Details Heparin Epoprostenol Flolan Increased risk of bleeding Details Heparin Etodolac Lodine An increased risk of bleeding Details Heparin Fenoprofen Fenopron An increased risk of bleeding Details Heparin Flurbiprofen Ansaid An increased risk of bleeding Details Heparin Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Heparin Fondaparinux Arixtra Increased risk of bleeding Details Heparin Fondaparinux Injection Arixtra Increased risk of bleeding Details Heparin Abciximab An increased risk of bleeding Details Heparin Aceclofenac An increased risk of bleeding Details Heparin Acemetacin An increased risk of bleeding Details Heparin Alipogene Tiparvovec An increased risk of bleeding Details Heparin Alprostadil An increased risk of bleeding Details Heparin Alteplase, Recombinant Activase An increased risk of bleeding Details Heparin Amtolmetin Guacil An increased risk of bleeding Details Heparin Anistreplase An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.