Levothyroxine
214 interactions 1 explained in plain English 219 cited referencesLevothyroxine is a hormone used to replace thyroid hormone and treat hypothyroidism and thyroid cancer. Read the full Levothyroxine drug information page →
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Moderate
Levothyroxine Tivozanib Fotivda Increased risk of hypothyroidism Details Levothyroxine Tofacitinib Xeljanz Increased risk of hypothyroidism Details Levothyroxine Tolazamide Tolinase® Worsening of glycemic control Details Levothyroxine Tolbutamide Orinase® Worsening of glycemic control Details Levothyroxine Tucatinib Tukysa Increased risk of hypothyroidism Details Levothyroxine Upadacitinib Rinvoq Increased risk of hypothyroidism Details Levothyroxine Vandetanib Caprelsa Increased risk of hypothyroidism Details Levothyroxine Vimseltinib Romvimza Increased risk of hypothyroidism Details Levothyroxine Warfarin Coumadin Increased response to warfarin therapy Details Levothyroxine Zanubrutinib Brukinsa Increased risk of hypothyroidism Details Levothyroxine Zongertinib Hernexeos Increased risk of hypothyroidism Details Levothyroxine Liraglutide Injection Saxenda Worsening of glycemic control Details Levothyroxine Lixisenatide Injection Adlyxin® Worsening of glycemic control DetailsNo interactions on this page match that filter — try the next page or clear the filter.
Check another drug
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist