Lisinopril and Pregabalin: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Pregabalin
Lisinopril
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
You've been prescribed pregabalin (Lyrica) for nerve pain or seizures and lisinopril for blood pressure. Each of these medicines, on its own, can rarely cause a reaction called angioedema, which is swelling of the face, lips, tongue, or throat. When you take both together, the concern is that the risk of that swelling could add up.
This is mostly a theoretical concern, so please don't panic. Most people take these together without any problem. Just know the warning signs: any swelling of your face, mouth, or throat, or trouble breathing. If that happens, treat it as an emergency and get help right away. Your care team can keep an eye on this for you.
Effect: Additive risk of angioedema with concomitant pregabalin and lisinopril (ACE inhibitor).
Mechanism: Additive, not pharmacokinetic. Both agents have independently caused angioedema (ACE inhibitors via bradykinin/substance P accumulation; pregabalin by an unclear mechanism). Neither is a prodrug and no CYP/transporter interaction is involved.
- Direction/magnitude: Presumed additive increase in angioedema risk; magnitude not quantified.
- Onset: Unspecified; angioedema reported during both initial and chronic therapy.
- Evidence: Theoretical.
- Management: Counsel on angioedema symptoms. If angioedema develops, discontinue both agents immediately and treat emergently.
What happens
Increased risk of angioedema
Interaction Deep Dive
When pregabalin is taken together with other agents linked to angioedema (for example, ACE inhibitors), the likelihood of angioedema developing may rise. Independently, angioedema has been reported in patients treated with pregabalin during both the early and long-term phases of therapy (including cases that were life-threatening)2, as well as in those taking ACE inhibitors (including fatal cases)1. Should any signs of angioedema appear, both the pregabalin and the ACE inhibitor should be stopped without delay 21.
Why it happens (mechanism)
Additive effects on angioedema
How to manage this interaction
Keep taking both medicines as prescribed unless your prescriber tells you otherwise. This risk is theoretical, and the two are often used together safely.
Here's what typically happens and what you can do:
- Learn the warning signs of angioedema: swelling of the face, lips, tongue, or throat, trouble swallowing, or trouble breathing.
- If any of these happen, treat it as a medical emergency and seek care right away. In that situation, both medicines would be stopped immediately.
- Tell your pharmacist or doctor if you have ever had swelling reactions before, so they can decide whether an alternative is right for you.
Management is individual — confirm any change with your pharmacist or prescriber.
Common questions
Can I take Lisinopril and Pregabalin together?
Taking pregabalin and lisinopril together may slightly raise the theoretical risk of angioedema (swelling of the face, lips, tongue, or throat). Keep taking both as prescribed, but if any such swelling or breathing trouble occurs, treat it as an emergency and get help right away. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Lisinopril and Pregabalin interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Lisinopril and Pregabalin interaction managed?
Keep taking both medicines as prescribed unless your prescriber tells you otherwise. This risk is theoretical, and the two are often used together safely. Here's what typically happens and what you can do: Learn the warning signs of angioedema: swelling of the face, lips, tongue, or throat, trouble swallowing, or trouble breathing. If any of these happen, treat it as a medical emergency and seek c… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Lisinopril or Pregabalin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
Keep reading about Pregabalin
Keep reading about Lisinopril
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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