Lovastatin and Voriconazole: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Voriconazole
Lovastatin
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased plasma levels of lovastatin and an increased risk of myopathy or rhabdomyolysis
Interaction Deep Dive
Concomitant use of lovastatin, a CYP3A4 substrate1, and voriconazole, a CYP3A4 inhibitor 2, is contraindicated, as this may result in increased plasma concentrations of lovastatin, and may increase the risk for myopathy, including rhabdomyolysis. If treatment with voriconazole is required, discontinue lovastatin therapy during administration 1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of lovastatin by voriconazole
Common questions
Can I take Lovastatin and Voriconazole together?
Increased plasma levels of lovastatin and an increased risk of myopathy or rhabdomyolysis Always confirm with your pharmacist or prescriber before making any change.
How serious is the Lovastatin and Voriconazole interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Lovastatin or Voriconazole need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: MEVACOR(R) oral tablets, lovastatin oral tablets. Merck Sharp & Dohme Corp. (per FDA), Whitehouse Station, NJ, 2012. DailyMed
- Product Information: VFEND(R) oral tablets, oral suspension, intravenous injection, voriconazole oral tablets, oral suspension, intravenous injection. Roerig(per FDA), New York, NY, 2011. DailyMed
Keep reading about Voriconazole
Keep reading about Lovastatin
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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