Methamphetamine and Linezolid Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Methamphetamine
Linezolid Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of serotonergic syndrome and an increased risk of hypertensive crisis
Interaction Deep Dive
Concomitant use of methamphetamine and monoamine oxidase inhibitors (MAOIs) is contraindicated, or within 14 days following discontinuation of treatment with an MAOIs because of the risk of hypertensive crisis. Toxic neurological effects and malignant hyperpyrexia can occur, sometimes with fatal results. Concomitant use may also cause serotonin syndrome, a potentially life-threatening reaction. Advise patients to contact their healthcare provider or report to the emergency room if they experience signs or symptoms of serotonin syndrome. Serotonin syndrome symptoms may include mental status changes, autonomic instability, neuromuscular symptoms, seizures, and/or gastrointestinal symptoms1.
Why it happens (mechanism)
Additive serotonergic effects; an increased amphetamine effects on the release of norepinephrine and other monoamines
Literature reports
1 report — tap to read
Common questions
Can I take Methamphetamine and Linezolid Injection together?
An increased risk of serotonergic syndrome and an increased risk of hypertensive crisis Always confirm with your pharmacist or prescriber before making any change.
How serious is the Methamphetamine and Linezolid Injection interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Methamphetamine or Linezolid Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (6)
- Product Information: DESOXYN oral tablets, methamphetamine hydrochloride oral tablets. Ajenat Pharmaceuticals, LLC(per FDA), Tampa, FL, 2024. DailyMed
- Krisko I, Lewis E, & Johnson JE: Severe hyperpyrexia due to tranylcypromine-amphetamine toxicity. Ann Intern Med 1969; 70:559-564. PubMed
- Lloyd JTA & Walker DRH: Death after combined dexamphetamine and phenelzine (letter). Br Med J 1965; 2:168-169. DOI
- Mason A: Fatal reaction associated with tranylcypromine and methylamphetamine (letter). Lancet 1962; 1:1073. DOI
- Dally PJ: Fatal reaction associated with tranylcypromine and methylamphetamine (letter). Lancet 1962; 1:1235-1236. DOI
- Goldberg LI: Monoamine oxidase inhibitors. Adverse reactions and possible mechanisms. JAMA 1964; 190:456-462. DOI
Keep reading about Methamphetamine
Keep reading about Linezolid Injection
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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