Morphine Injection

437 interactions 767 cited references

Also sold as: Astramorph® PF Duramorph Duramorph® Infumorph Infumorph® Kadian Mitigo MS Contin

About Morphine Injection

Morphine injection is used to relieve moderate to severe pain. Morphine is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain. Read the full Morphine Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Samidorphan Safinamide Rasagiline Phenelzine Ozanimod Procarbazine

12 Contraindicated 409 Major 16 Moderate

All (437) Contraindicated (12) Major (409) Moderate (16)

Major

Morphine Injection Umeclidinium Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Injection Vandetanib Caprelsa Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Velpatasvir Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Vemurafenib Zelboraf Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Venetoclax Venclexta Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Venlafaxine Increased risk of serotonin syndrome Details Morphine Injection Verapamil Calan Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Vibegron Gemtesa Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Vilazodone Viibryd Increased morphine exposure, increased risk of morphine-related adverse effects (hypotension, respiratory depression, profound sed... Details Morphine Injection Voclosporin Lupkynis Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Vorapaxar Zontivity Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Vortioxetine Trintellix Increased risk of serotonin syndrome Details Morphine Injection Xipamide Reduced efficacy of diuretics Details Morphine Injection Zaleplon Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Zanubrutinib Brukinsa Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Injection Ziprasidone Geodon Increased risk for serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) and an increased risk of CNS... Details Morphine Injection Zolmitriptan Zomig Increased risk of serotonin syndrome Details Morphine Injection Zolpidem Ambien Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Zopiclone Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Zotepine Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Injection Zuranolone Zurzuvae An increased risk of CNS depression Details

Moderate

Morphine Injection Brimonidine Alphagan An increased risk of CNS depression Details Morphine Injection Carbachol Isopto Carbachol An increased risk of CNS depression Details Morphine Injection Chloroprocaine Antagonism of the analgesic effect of epidural morphine by epidural chloroprocaine Details Morphine Injection Clonidine Duraclon An increased risk of sedation and somnolence Details Morphine Injection Desflurane Suprane Reduced desflurane (MAC) exposure needed to produce anesthesia Details Morphine Injection Desmopressin DDAVP Increased risk of water intoxication with hyponatremia Details Morphine Injection Esmolol Brevibloc Esmolol toxicity (bradycardia, hypotension) Details Morphine Injection Ganaxolone Ztalmy An increased risk of somnolence and sedation Details Morphine Injection Kava Increased central nervous system depression Details Morphine Injection Norethindrone Aygestin Reduced morphine exposure Details Morphine Injection Norgestimate Reduced morphine exposure Details Morphine Injection Sevoflurane Petrem Reduced sevoflurane (MAC) exposure needed to produce anesthesia and an increased risk of respiratory depression Details Morphine Injection Somatostatin Reduced analgesic effect of morphine Details Morphine Injection Trovafloxacin Mesylate Reduced efficacy of trovafloxacin Details Morphine Injection Valerian Additive central nervous system depression Details Morphine Injection Yohimbine Increased analgesic and adverse effects of morphine Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.