Naloxegol and Boceprevir: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Boceprevir
No brand names on recordNaloxegol
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects
Interaction Deep Dive
Concomitant use of naloxegol (a CYP3A4 substrate) and a strong CYP3A4 inhibitor is contraindicated, as it may increase the naloxegol exposure, causing opioid withdrawal symptoms such as hyperhidrosis, chills, diarrhea, abdominal pain, anxiety, irritability, and yawning1.
Why it happens (mechanism)
Inhibition of CYP3A4 mediated metabolism of naloxegol
Literature reports
1 report — tap to read
a) Coadministration of once daily oral ketoconazole 400 mg and naloxegol 25 mg resulted in an approximate 10-fold and 13-fold increase in the Cmax and AUC, respectively 1.
Common questions
Can I take Naloxegol and Boceprevir together?
Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Always confirm with your pharmacist or prescriber before making any change.
How serious is the Naloxegol and Boceprevir interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Naloxegol or Boceprevir need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: MOVANTIK(R) oral tablets, naloxegol oral tablets. AstraZeneca Pharmaceuticals LP (per FDA), Wilmington, DE, 2020. DailyMed
Keep reading about Boceprevir
Keep reading about Naloxegol
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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