Naloxegol

105 interactions 1 explained in plain English 270 cited references
Also sold as: Movantik Movantik®
About Naloxegol

Naloxegol is used to treat constipation caused by opiate (narcotic) pain medications in adults with chronic (ongoing) pain that is not caused by cancer. Naloxegol is in a class of medications called peripherally acting mu-opioid receptor antagonists. It works by protecting the bowel from the effects of opiate (narcotic… Read the full Naloxegol drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ceritinib Cobicistat Darunavir Voriconazole Boceprevir Clarithromycin
27 Contraindicated 72 Major 6 Moderate
All (105) Contraindicated (27) Major (72) Moderate (6)

Contraindicated

Naloxegol Ketoconazole Topical Extina® Foam Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Boceprevir Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Ceritinib Zykadia Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Clarithromycin Biaxin Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Cobicistat Tybost Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Darunavir Increased naloxegol exposure Details Naloxegol Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Naloxegol Idelalisib Zydelig Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Indinavir Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Itraconazole Sporanox Increased naloxegol exposure Details Naloxegol Ketoconazole Extina Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Levoketoconazole Recorlev Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Naloxegol Lonafarnib Zokinvy Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Mifepristone Korlym Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Nefazodone Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Nelfinavir Viracept Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Nirmatrelvir Increased naloxegol exposure and increased risk of opioid withdrawal symptoms Details Naloxegol Paritaprevir Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Posaconazole Noxafil Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Ribociclib Kisqali Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Ritonavir Norvir Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Saquinavir Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Telaprevir Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Telithromycin Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Troleandomycin Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Tucatinib Tukysa Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details Naloxegol Voriconazole Vfend Increased naloxegol exposure and an increased risk of naloxegol-related adverse effects Details

Major

Naloxegol Abametapir Increased exposure of CYP3A4 substrate Details Naloxegol Alvimopan Entereg Risk of opioid withdrawal Details Naloxegol Abiraterone Abirtega Increased naloxegol exposure Details Naloxegol Encorafenib Braftovi Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Naloxegol Lefamulin Xenleta Increased sensitive CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related toxicities associated wi... Details Naloxegol Lenacapavir Injection Sunlenca Increased naloxegol exposure Details Naloxegol Lenacapavir Oral Sunlenca Increased naloxegol exposure Details Naloxegol Letermovir Injection Prevymis Increased naloxegol exposure Details Naloxegol Methylnaltrexone Relistor Risk of opioid withdrawal Details Naloxegol Methylnaltrexone Injection Relistor Risk of opioid withdrawal Details Naloxegol Miconazole Buccal Oravig Increased naloxegol exposure Details Naloxegol Miconazole Topical Aloe Vesta Antifungal Increased naloxegol exposure Details Naloxegol Miconazole Vaginal Lagicam Increased naloxegol exposure Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.