Oxprenolol

59 interactions 2 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Albuterol Oral Inhalation Clonidine Transdermal Patch Indacaterol Oral Inhalation Lacosamide Injection Methylergonovine Olodaterol Oral Inhalation

6 Major 53 Moderate

All (59) Major (6) Moderate (53)

Major

Oxprenolol Albuterol Oral Inhalation Accuneb® Explained Reduced efficacy of albuterol Details Oxprenolol Clonidine Transdermal Patch Catapres An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Oxprenolol Indacaterol Oral Inhalation Arcapta® Decreased efficacy of indacaterol Details Oxprenolol Lacosamide Injection Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Oxprenolol Methylergonovine Methergine An increased risk of enhanced vasoconstrictive Details Oxprenolol Olodaterol Oral Inhalation Striverdi Reduced olodaterol exposure and reduced beta-adrenergic blockers exposure Details

Moderate

Oxprenolol Acarbose Prandase® Explained Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Oxprenolol Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Oxprenolol Aspirin Acuprin® Reduced antihypertensive effect Details Oxprenolol Aspirin Rectal Aspirin Reduced antihypertensive effect Details Oxprenolol Alfuzosin UroXatral An exaggerated hypotensive response to the first dose of the alpha blocker Details Oxprenolol Alogliptin Nesina Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Oxprenolol Bromfenac Ophthalmic Bromday® Reduced antihypertensive effect Details Oxprenolol Canagliflozin Invokana Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Oxprenolol Dapagliflozin Farxiga Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Oxprenolol Diclofenac Ophthalmic Voltaren® Eye Drops Reduced antihypertensive effect Details Oxprenolol Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced antihypertensive effect Details Oxprenolol Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced antihypertensive effect Details Oxprenolol Diclofenac Transdermal Patch Flector Reduced antihypertensive effect Details Oxprenolol Digoxin Cardoxin® Increased risk of bradycardia and possible digitalis glycoside toxicity Details Oxprenolol Doxazosin Cardura An exaggerated hypotensive response to the first dose of the alpha blocker Details Oxprenolol Dulaglutide Injection Trulicity Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Oxprenolol Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Oxprenolol Ertugliflozin Steglatro Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Oxprenolol Etodolac Lodine Reduced antihypertensive effect Details Oxprenolol Exenatide Injection Bydureon Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Oxprenolol Fenoprofen Fenopron Reduced antihypertensive effect Details Oxprenolol Flurbiprofen Ansaid Reduced antihypertensive effect Details Oxprenolol Flurbiprofen Ophthalmic Ocufen Reduced antihypertensive effect Details Oxprenolol Glimepiride Amaryl Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Oxprenolol Glipizide Glucotrol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Oxprenolol Glucagon Injection Baqsimi A transient increase in pulse and blood pressure Details Oxprenolol Glucagon Injection / Solution Baqsimi A transient increase in pulse and blood pressure Details Oxprenolol Glucagon Nasal Powder Baqsimi A transient increase in pulse and blood pressure Details Oxprenolol Hydralazine Apresoline® An increased risk of oxprenolol adverse effects (bradycardia, fatigue, bronchospasm) Details Oxprenolol Ibuprofen Addaprin Reduced antihypertensive effect Details Oxprenolol Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Oxprenolol Insulin Detemir (Rdna Origin) Injection Levemir Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Oxprenolol Insulin Glulisine (Rdna Origin) Injection Apidra Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Oxprenolol Ketoprofen Actron® Reduced antihypertensive effect Details

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