Palovarotene

16 interactions 1 explained in plain English
Also sold as: Sohonos
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Minocycline Topical Ketoconazole Topical Letermovir Injection Minocycline Omadacycline Omadacycline Injection
16 Major
All (16) Major (16)

Major

Palovarotene Isotretinoin Absorica Explained Increased risk of hypervitaminosis A Details Palovarotene Acitretin Soriatane® Increased risk of hypervitaminosis A Details Palovarotene Bexarotene Targretin Increased risk of hypervitaminosis A Details Palovarotene Bexarotene Topical Targretin Increased risk of hypervitaminosis A Details Palovarotene Cyclosporine Injection Atopica Increased palovarotene exposure and an increased risk of palovarotene-related adverse effects Details Palovarotene Cyclosporine Ophthalmic Cequa Increased palovarotene exposure and an increased risk of palovarotene-related adverse effects Details Palovarotene Demeclocycline Declomycin® Increased risk of benign intracranial hypertension (pseudotumor cerebri) Details Palovarotene Doxycycline Injection Acticlate Increased risk of benign intracranial hypertension (pseudotumor cerebri) Details Palovarotene Eravacycline Injection Xerava Increased risk of benign intracranial hypertension (pseudotumor cerebri) Details Palovarotene Ketoconazole Topical Extina® Foam Increased palovarotene exposure and an increased risk of palovarotene-related adverse effects Details Palovarotene Letermovir Injection Prevymis Increased palovarotene exposure and an increased risk of palovarotene-related adverse effects Details Palovarotene Minocycline Amzeeq Increased risk of benign intracranial hypertension (pseudotumor cerebri) Details Palovarotene Minocycline Topical Amzeeq Increased risk of benign intracranial hypertension (pseudotumor cerebri) Details Palovarotene Nafcillin Injection Unipen® Injection Reduced palovarotene exposure and reduced efficacy of palovarotene Details Palovarotene Omadacycline Nuzyra Increased risk of benign intracranial hypertension (pseudotumor cerebri) Details Palovarotene Omadacycline Injection Nuzyra Increased risk of benign intracranial hypertension (pseudotumor cerebri) Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.