Penicillin V Potassium

50 interactions 272 cited references
Also sold as: Beepen-VK® Betapen-VK® Ledercillin VK® Pen-Vee K® Penapar-VK® Uticillin VK® V-Cillin K® Veetids®
About Penicillin V Potassium

Penicillin V potassium is used to treat certain infections caused by bacteria such as pneumonia and other respiratory tract infections, scarlet fever, and ear, skin, gum, mouth, and throat infections. It also is used to prevent rheumatic fever (a serious condition that may develop after a strep throat or scarlet fever… Read the full Penicillin V Potassium drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Amifampridine Bupropion Chlortetracycline Cholera Vaccine, Live Clomipramine Demeclocycline
36 Major 3 Moderate 11 Minor
All (50) Major (36) Moderate (3) Minor (11)

Major

Penicillin V Potassium Amifampridine Increased risk of seizures Details Penicillin V Potassium Bupropion Aplenzin Increased risk of seizures Details Penicillin V Potassium Chlortetracycline Decreased antibacterial effectiveness Details Penicillin V Potassium Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Penicillin V Potassium Clomipramine Anafranil Increased risk of seizures Details Penicillin V Potassium Demeclocycline Declomycin® Decreased antibacterial effectiveness Details Penicillin V Potassium Desogestrel Decreased contraceptive effectiveness Details Penicillin V Potassium Dienogest Decreased contraceptive effectiveness Details Penicillin V Potassium Donepezil Adlarity Reduced seizure threshold Details Penicillin V Potassium Doxycycline Acticlate Decreased antibacterial effectiveness Details Penicillin V Potassium Drospirenone Decreased contraceptive effectiveness Details Penicillin V Potassium Eravacycline Xerava Decreased antibacterial effectiveness Details Penicillin V Potassium Estradiol Delestrogen Decreased contraceptive effectiveness Details Penicillin V Potassium Ethinyl Estradiol Decreased contraceptive effectiveness Details Penicillin V Potassium Ethynodiol Decreased contraceptive effectiveness Details Penicillin V Potassium Exenatide Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Penicillin V Potassium Gestodene Decreased contraceptive effectiveness Details Penicillin V Potassium Hydroxychloroquine Plaquenil An increased risk of seizures Details Penicillin V Potassium Levonorgestrel After banger Decreased contraceptive effectiveness Details Penicillin V Potassium Lymecycline Decreased antibacterial effectiveness Details Penicillin V Potassium Meclocycline Decreased antibacterial effectiveness Details Penicillin V Potassium Mestranol Decreased contraceptive effectiveness Details Penicillin V Potassium Methacycline Decreased antibacterial effectiveness Details Penicillin V Potassium Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Penicillin V Potassium Minocycline Amzeeq Decreased antibacterial effectiveness Details Penicillin V Potassium Nomegestrol Decreased contraceptive effectiveness Details Penicillin V Potassium Norethindrone Aygestin Decreased contraceptive effectiveness Details Penicillin V Potassium Norgestimate Decreased contraceptive effectiveness Details Penicillin V Potassium Norgestrel Decreased contraceptive effectiveness Details Penicillin V Potassium Oxytetracycline Decreased antibacterial effectiveness Details Penicillin V Potassium Rolitetracycline Decreased antibacterial effectiveness Details Penicillin V Potassium Sarecycline Seysara Decreased antibacterial effectiveness Details Penicillin V Potassium Tetracycline Achromycin V® Decreased antibacterial effectiveness Details Penicillin V Potassium Tigecycline Tygacil Decreased antibacterial effectiveness Details Penicillin V Potassium Tramadol ConZip An increased risk of seizure Details Penicillin V Potassium Warfarin Coumadin An increased risk of bleeding Details

Moderate

Penicillin V Potassium Guar Gum Decreased penicillin effectiveness Details Penicillin V Potassium Lixisenatide Delayed therapeutic effect Details Penicillin V Potassium Typhoid Vaccine, Live Vivotif A decreased immunological response to the typhoid vaccine Details

Minor

Penicillin V Potassium Amikacin Loss of aminoglycoside efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.