Promazine
27 interactions 2 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Metoclopramide Injection
Metoclopramide Nasal Spray
Fentanyl Transdermal Patch
Butorphanol Injection
Butorphanol Nasal Spray
Lacosamide Injection
Contraindicated
Promazine Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Promazine Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome DetailsMajor
Promazine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Promazine Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Promazine Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Promazine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Promazine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Promazine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Promazine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Promazine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Promazine Diazepam Rectal Diastat Increased risk of CNS depression Details Promazine Esketamine Nasal Spray Spravato Increased risk of sedation Details Promazine Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Promazine Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Promazine Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Promazine Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Promazine Hydroxychloroquine Plaquenil An increased risk of seizures Details Promazine Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Promazine Lacosamide Injection Motpoly An increased risk of CNS depression Details Promazine Levodopa Oral Inhalation Inbrija Reduce efficacy of levodopa (foslevodopa), an increased risk of exacerbating psychosis [or symptoms of Parkinson's disease: delusi... Details Promazine Lithium Carbonate Lithobid Weakness, dyskinesias, increased extrapyramidal symptoms, encephalopathy, and brain damage Details Promazine Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Promazine Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Promazine Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Promazine Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) DetailsModerate
Promazine Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Promazine Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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