Drug & supplement interaction

Abuta + Mefenamic Acid

Mefenamic Acid brand name: Ponstel.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Abuta and Mefenamic Acid in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Abuta and Mefenamic Acid

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Mefenamic Acid and Abuta in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Abuta safety at a glance

Abuta overall Use caution Human safety data are limited, so use cautiously and under professional guidance.
Pregnancy Avoid Traditionally used to affect the uterus and childbirth; avoid during pregnancy.
Breastfeeding Avoid No reliable safety data while breastfeeding; best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Mefenamic Acid and Abuta? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Mefenamic Acid

Interactions in our licensed database are recorded against drug classes, not just single drug names. Mefenamic Acid is filed under 8 classifications — including nonsteroidal anti-inflammatory drugs (nsaids), cytochrome p450 2c9 (cyp2c9) substrates, organic anion transporter 3 (oat3) substrates. Abuta has documented interactions with 1 drug class — the most serious being diuretic drugs (moderate) — and none of Mefenamic Acid’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Abuta Does Interact With Other Medications

Abuta has 75 moderate known drug interactions in our database — Mefenamic Acid isn’t one of them. If you take anything else, check it against the full list below.

Moderate 75 No known interaction 2,755 (incl. Mefenamic Acid)
Taking anything else?

Check Another of Your Medications Against Abuta

Covers the 2,830 medications we’ve checked against Abuta. Pick one to open its full report.

What to actually watch for

What Mefenamic Acid’s Own FDA Label Lists

This is not an interaction — none of it involves Abuta. These are the most notable effects listed in the ADVERSE REACTIONS section of Mefenamic Acid’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Pain or burning when passing urine Worth acting on
  • Bleeding in the gut Worth acting on
  • High potassium Worth acting on
  • A heart attack Worth acting on
  • Hallucinations Worth acting on
  • Pancreatitis Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Heart failure Worth acting on
  • High blood sugar Worth acting on
  • Fainting Worth acting on

Showing the 10 most notable of 55 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Mefenamic Acid. Read the label on DailyMed › Where a percentage is shown, it is the share of 2,182 voluntary FDA FAERS reports for Mefenamic Acid that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Abuta’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Abuta side to compare — that is a limit of the record, not a statement that Abuta has no side effects.

Everything else you take

See Every Supplement That Interacts With Mefenamic Acid

This page covers Abuta only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Mefenamic Acid page lists 118 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Siberian Cocklebur (major) and Wine (major).

By severity: 5 major · 86 moderate · 27 minor.

From our pharmacist’s overview on the Mefenamic Acid page

“Mefenamic acid (Ponstel), an NSAID mostly used for menstrual cramps and short-term pain, has a supplement list that earns genuine caution, and the five major-rated entries are where to start. Beer and wine are two of them, because alcohol plus any NSAID raises the risk of stomach and intestinal bleeding.”

Reviewed by 2 · Jul 18, 2026

Open the Mefenamic Acid interaction page

One more smart check

Taking Abuta as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Abuta, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Abuta. Even though Abuta itself has no known interaction with Mefenamic Acid, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Abuta and Mefenamic Acid Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Abuta
Top half

#522 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Mefenamic Acid
Steady interest

#1,905 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Abuta reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Abuta and Mefenamic Acid records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Abuta

What is Abuta?

Abuta
  • Menstrual cramps and women's health
  • Kidney and urinary tract complaints
  • Digestive upset
  • Fever
  • Traditional support during pregnancy and childbirth

Abuta (Cissampelos pareira) is a tropical climbing plant used in traditional medicine, especially for menstrual and urinary complaints. Good-quality human studies are lacking, so its benefits and safety are not well established. Because of uncertain safety—and its traditional use to affect the uterus—it should be avoided during pregnancy and breastfeeding and discussed with a pharmacist or doctor first.

Cissampelos pareira · Menispermaceae · Root (most common), with bark, seeds, and above-ground parts also used · Dried root, tea/decoction, tincture, capsules, powder

An interaction check asks whether these two react with each other — it does not ask whether Abuta is a good idea for someone in your situation. Here is what our Abuta record says about it on its own.

Abuta: dosing

There is no established, standardized dose of abuta. Traditional preparations vary, and modern supplements come in different strengths and forms, so there is no single recommended amount that has been proven safe and effective.If you choose to use a product, follow the directions on the label and do not exceed them.

From our Abuta monograph — the full record covers uses, side effects and every documented interaction.

Read the full Abuta monograph & all interactions
Medication

About Mefenamic Acid

What Is Mefenamic Acid Used For?

Brand name: Ponstel

Mefenamic acid capsules are approved to manage mild to moderate pain in adults and adolescents 14 years of age and older, but only for short-term use — no longer than 7 days.

They are also approved to treat primary dysmenorrhea (painful menstrual periods), started at the onset of bleeding and associated symptoms.

Most-Reported Side Effects for Mefenamic Acid

From FAERS, the FDA’s public side-effect reporting system (2,182 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 314 reports
Fatigue 264 reports
Headache 238 reports
Dizziness 189 reports
Malaise 177 reports
See full Mefenamic Acid drug information
Keep checking

Other Drugs & Abuta

Browse every other medication we’ve checked against Abuta — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
75Moderate
0Minor
2,754No known interaction
75 Moderate 2,754 No interaction
Moderate

75 interactions

Showing 60 of 75 moderate interactions — see all 75 on the Abuta page.

No interaction 2,754 drugs checked — show the list

We also checked Abuta against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,754 medications checked with no known interaction — see the full Abuta list.

See the full Abuta interactions page
See every supplement checked against Mefenamic Acid, ranked by severity
Evidence & sources

Abuta References

The 1 references that drive our Abuta monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Sayana SB, Khanwelkar CC, Nimmagadda VR, et al. Evaluation of diuretic activity of alcoholic extract of roots of cissampelos pareira in albino rats. J Clin Diagn Res. 2014;8(5):HC01-4.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Abuta and Mefenamic Acid Together: Common Questions

Is it safe to take Abuta with Mefenamic Acid?
We do not list a known interaction between Abuta and Mefenamic Acid. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Abuta and Mefenamic Acid combination checked?
Interactions in our licensed database are recorded against drug classes. Mefenamic Acid is filed under 8 classifications, and Abuta has documented interactions with 1 drug class — none of Mefenamic Acid's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Abuta interact with any other medications?
Yes. Abuta has 75 documented drug interactions in our database — Mefenamic Acid is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Mefenamic Acid interact with any supplements?
Yes. Mefenamic Acid has documented interactions with 118 supplements in our database — Abuta is not one of them. The Mefenamic Acid interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Abuta monograph Uses, safety profile, and every drug interaction in one place Mefenamic Acid drug information The full plain-English guide to this medication Mefenamic Acid supplement interactions Every supplement checked against Mefenamic Acid, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Mefenamic Acid and Abuta?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.