Drug & supplement interaction

Aletris + Alpelisib

Alpelisib brand name: Piqray.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Aletris and Alpelisib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Alpelisib states a food rule worth keeping to.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Aletris and Alpelisib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Alpelisib and Aletris in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Aletris safety at a glance

Aletris overall Use caution Limited modern safety data; large or fresh doses may cause stomach upset.
Pregnancy Possibly Unsafe When used orally due to the possibility that aletris contains components that cause estrogenic activity and oxytocin (Pitocin) antagonism; avoid using. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally due to the possibility that aletris contains components that cause estrogenic activity and oxytocin (Pitocin) antagonism; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Alpelisib and Aletris? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Alpelisib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Alpelisib is filed under 3 classifications — cytochrome p450 2c9 (cyp2c9) inducers, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Aletris has documented interactions with 4 drug classes — the most serious being estrogens (moderate), antacids (minor) and h2-blockers (minor) — and none of Alpelisib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Aletris Does Interact With Other Medications

Aletris has 41 moderate, 36 minor known drug interactions in our database — Alpelisib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 41 Minor 36 No known interaction 2,753 (incl. Alpelisib)
Taking anything else?

Check Another of Your Medications Against Aletris

Covers the 2,830 medications we’ve checked against Aletris. Pick one to open its full report.

What to actually watch for

What Aletris Itself Has Been Linked To

This is not an interaction — nothing below involves Alpelisib. It is the side-effect record for Aletris on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Aletris, this list is the first place to look.

  • Dizziness Additional detail

    “There is currently a limited amount of information available about the adverse effects of aletris. Orally, aletris has been reported to cause colic, stupefaction, and vertigo (6).”

    Aletris · Natural Medicines adverse-effect record, reported in vertigo.

    1 source cited
    1. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

    “Orally, small doses of aletris have been reported to cause stupefaction and vertigo (6).”

    Aletris · Natural Medicines adverse-effect record, reported in vertigo.

    1 source cited
    1. 6. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.

Everything above comes from the Natural Medicines adverse-effect record for Aletris — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Alpelisib’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Alpelisib column appears here.

Special populations

Aletris in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally due to the possibility that aletris contains components that cause estrogenic activity and oxytocin (Pitocin) antagonism; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Alpelisib Products Have a Food Rule — Aletris Should Not Break It

At least one FDA label for a product containing Alpelisib says to take it with food. If you take Aletris on an empty stomach out of habit, keep them separate — and take Alpelisib with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Alpelisib products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

2 DOSAGE AND ADMINISTRATION Recommended Dose: Pediatric patients (2 to less than 18 years of age): 50 mg taken orally once daily with food.

From the Dosage and Administration section of the FDA label we read for Alpelisib — where that label names a specific product, the instruction is that product's. See the Alpelisib drug page ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Alpelisib

This page covers Aletris only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Alpelisib page lists 139 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 96 moderate · 40 minor.

From our pharmacist’s overview on the Alpelisib page

“Alpelisib (Piqray) treats PIK3CA-mutated breast cancer, and a drug doing that job leaves little room for supplements that shift its blood level. Yet that is what most of this list does: 121 of the 139 ingredients on file can raise or lower alpelisib through CYP3A4, the liver enzyme that clears it.”

Reviewed by 2 · Jul 18, 2026

Open the Alpelisib interaction page

One more smart check

Taking Aletris as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Aletris, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Aletris. Even though Aletris itself has no known interaction with Alpelisib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Aletris and Alpelisib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Aletris
Top half

#666 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Alpelisib
Steady interest

#1,611 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Aletris reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Aletris and Alpelisib records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Aletris

What is Aletris?

Aletris
  • Menstrual complaints
  • Digestive upset and colic
  • Loss of appetite
  • Female reproductive tonic
  • Rheumatic discomfort

Aletris (true unicorn root or colic root) is a North American herb traditionally used for menstrual problems and digestive complaints, but there is little to no modern human research to show it works. Because safety is poorly studied, it should be avoided during pregnancy and breastfeeding, and anyone considering it should first talk with a pharmacist or doctor.

Aletris farinosa · Nartheciaceae · Root and rhizome · Dried root, tincture, liquid extract, capsules, tea

An interaction check asks whether these two react with each other — it does not ask whether Aletris is a good idea for someone in your situation. Here is what our Aletris record says about it on its own.

Aletris: dosing

There is no established, scientifically supported dose for Aletris. Traditional dosing has varied widely depending on the form (dried root, tea, or tincture) and is not based on modern research.If you choose to use a product, follow the directions on the label and do not exceed them.

From our Aletris monograph — the full record covers uses, side effects and every documented interaction.

Read the full Aletris monograph & all interactions
Medication

About Alpelisib

What Is Alpelisib Used For?

Brand name: Piqray

Alpelisib is approved for two distinct uses, each tied to a specific brand. Piqray is used in combination with another drug called fulvestrant to treat adults with hormone receptor (HR)-positive, HER2-negative, advanced or metastatic breast cancer whose tumors carry a PIK3CA mutation — and only after the cancer has progressed on or after a hormone-based treatment. A companion diagnostic test is required before starting Piqray.

Vijoice is used to treat adults and children 2 years of age and older who have severe manifestations of PIK3CA-Related Overgrowth Spectrum (PROS) — a rare condition where PIK3CA gene mutations cause abnormal tissue, vascular, and bone overgrowth — and who need systemic (whole-body) therapy. Vijoice's approval for PROS was granted under the FDA's accelerated approval pathway based on response data, and continued approval may depend on confirmatory trials.

See full Alpelisib drug information
Keep checking

Other Drugs & Aletris

Browse every other medication we’ve checked against Aletris — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
41Moderate
36Minor
2,752No known interaction
41 Moderate 36 Minor 2,752 No interaction
Moderate

41 interactions

Minor

36 interactions

No interaction 2,752 drugs checked — show the list

We also checked Aletris against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,752 medications checked with no known interaction — see the full Aletris list.

See the full Aletris interactions page
See every supplement checked against Alpelisib, ranked by severity
Evidence & sources

Aletris References

The 4 references that drive our Aletris monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Aletris and Alpelisib Together: Common Questions

Is it safe to take Aletris with Alpelisib?
We do not list a known interaction between Aletris and Alpelisib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Aletris and Alpelisib at the same time of day?
At least one FDA label for a product containing Alpelisib says to take it with food. If you take Aletris on an empty stomach out of habit, keep them separate and take Alpelisib with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Alpelisib products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Aletris and Alpelisib combination checked?
Interactions in our licensed database are recorded against drug classes. Alpelisib is filed under 3 classifications, and Aletris has documented interactions with 4 drug classes — none of Alpelisib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Aletris interact with any other medications?
Yes. Aletris has 77 documented drug interactions in our database — Alpelisib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Alpelisib interact with any supplements?
Yes. Alpelisib has documented interactions with 139 supplements in our database — Aletris is not one of them. The Alpelisib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Aletris monograph Uses, safety profile, and every drug interaction in one place Alpelisib drug information The full plain-English guide to this medication Alpelisib supplement interactions Every supplement checked against Alpelisib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Alpelisib and Aletris?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.