Drug & supplement interaction

Aletris + Ranitidine Bismuth Citrate

Ranitidine Bismuth Citrate brand name: Tritec.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Aletris has a minor interaction with Ranitidine Bismuth Citrate. Theoretically, due to reports that aletris increases stomach acid, aletris might decrease the effectiveness of H2-blockers.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Aletris and Ranitidine Bismuth Citrate

Here is the interaction we found between these two, with the evidence behind it.

Minor

H2-BLOCKERS

Why this applies to Ranitidine Bismuth Citrate

Ranitidine Bismuth Citrate falls under H2-BLOCKERS — the group Aletris interacts with.

Theoretically, due to reports that aletris increases stomach acid, aletris might decrease the effectiveness of H2-blockers. The H2 blockers include cimetidine (Tagamet), ranitidine (Zantac), nizatidine (Axid), and famotidine (Pepcid).
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version. Your medicine (ranitidine bismuth citrate, brand Tritec) works by turning down how much acid your stomach makes, which helps your ulcer or heartburn heal. The concern with aletris is that this herb has been reported, in a very informal way, to increase stomach acid. If that's true, it could work against your medicine and make it a little less effective, so you might notice more heartburn, sour stomach, or stomach discomfort sneaking back.

I want to be honest about how shaky this is. It's rated minor and rests only on anecdotal reports, not solid studies. For most people it likely won't be a big deal. Still, since you're treating something real like an ulcer, I'd skip the aletris and check with your pharmacist or doctor first before mixing the two.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Aletris Also Interacts With Other Medications

Aletris has 41 moderate, 35 minor known drug interactions in our database — the Ranitidine Bismuth Citrate one above is one of them. If you take anything else, check it against the full list below.

Moderate 41 Minor 35 No known interaction 2,754 (incl. Ranitidine Bismuth Citrate)
Taking anything else?

Check Another of Your Medications Against Aletris

Covers the 2,830 medications we’ve checked against Aletris. Pick one to open its full report.

From our Q&A

Questions About Aletris or Ranitidine Bismuth Citrate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Aletris or Ranitidine Bismuth Citrate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Ranitidine Bismuth Citrate

This page covers Aletris only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ranitidine Bismuth Citrate page lists 73 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), St. John's Wort (major), African Wild Potato (moderate), Banderol (moderate) and Beer (moderate).

By severity: 2 major · 43 moderate · 28 minor.

Open the Ranitidine Bismuth Citrate interaction page

One more smart check

Taking Aletris as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Aletris, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Aletris. Your product may carry other ingredients that interact with Ranitidine Bismuth Citrate too, on top of Aletris — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Aletris and Ranitidine Bismuth Citrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Aletris
Top half

#559 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ranitidine Bismuth Citrate
Steady interest

#2,432 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Aletris

What is Aletris?

Aletris
  • Menstrual complaints
  • Digestive upset and colic
  • Loss of appetite
  • Female reproductive tonic
  • Rheumatic discomfort

Aletris (true unicorn root or colic root) is a North American herb traditionally used for menstrual problems and digestive complaints, but there is little to no modern human research to show it works. Because safety is poorly studied, it should be avoided during pregnancy and breastfeeding, and anyone considering it should first talk with a pharmacist or doctor.

Read the full Aletris monograph & all interactions
Medication

About Ranitidine

What Is Ranitidine Used For?

Brand name: Tritec

Ranitidine treats a range of stomach acid–related conditions. Prescription-strength ranitidine (capsules, tablets, and oral solution) is used for active duodenal ulcers (ulcers in the small intestine), active benign gastric ulcers (stomach ulcers), GERD (acid reflux disease), erosive esophagitis (acid damage to the esophagus), and pathological hypersecretory conditions — rare disorders where the stomach makes far too much acid, such as Zollinger-Ellison syndrome. It is also used as maintenance therapy to keep duodenal and gastric ulcers from coming back after they have healed.

Over-the-counter products — including Acid Reducer and Acid Reducer 150 tablets — are approved to relieve heartburn associated with acid indigestion and sour stomach, and to prevent that heartburn when taken before eating or drinking foods that trigger it.

See full Ranitidine drug information
Keep checking

Other Drugs & Aletris

Browse every other medication we’ve checked against Aletris — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
41Moderate
35Minor
2,753No known interaction
41 Moderate 35 Minor 2,753 No interaction
Moderate

41 interactions

Minor

35 interactions

No interaction 2,753 drugs checked — show the list

We also checked Aletris against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,753 medications checked with no known interaction — see the full Aletris list.

See the full Aletris interactions page
See every supplement checked against Ranitidine Bismuth Citrate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Aletris monograph › Uses, safety, and every drug interaction in one place Ranitidine Bismuth Citrate supplement interactions › Every supplement checked against Ranitidine Bismuth Citrate, ranked by severity Ranitidine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Aletris and Ranitidine Bismuth Citrate Together: Common Questions

Can you take Aletris with Ranitidine Bismuth Citrate?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Aletris and Ranitidine Bismuth Citrate interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ranitidine Bismuth Citrate and Aletris?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.