Drug & supplement interaction

Allspice + Regorafenib

Regorafenib brand name: Stivarga.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Allspice and Regorafenib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Allspice and Regorafenib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Regorafenib and Allspice in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Allspice safety at a glance

Allspice overall Use caution Food amounts are generally safe, but concentrated extracts and essential oil need caution and lack strong safety data.
Pregnancy Likely Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of allspice when used in larger amoun... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of allspice when used in larger amoun... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Regorafenib and Allspice? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Regorafenib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Regorafenib is filed under 2 classifications — cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Allspice has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Regorafenib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Allspice Does Interact With Other Medications

Allspice has 122 moderate known drug interactions in our database — Regorafenib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Regorafenib)
Taking anything else?

Check Another of Your Medications Against Allspice

Covers the 2,830 medications we’ve checked against Allspice. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Allspice and Regorafenib May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A skin rash Additional detail

    Allspice

    “Orally and topically, allspice can cause allergic dermatitis in sensitive people. A case report describes a 41-year-old female with a history of allergic reactions to certain foods and drinks, with symptoms including lip angioedema, generalized hives and urticaria, vomiting, difficulty breathing, sneezing, ocular pruritus, and lacrimation, which responded to oral diphenhydramine.”

    Allspice · Natural Medicines adverse-effect record, reported in dermatitis.

    3 sources cited
    1. 12635. Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62. PubMed
    2. 30654. Niinimaki, A. Delayed-type allergy to spices. Contact Dermatitis 1984;11(1):34-40. PubMed
    3. 109925. Regula P, Edelman D, Ferastraoaru D, Ramesh M, Hudes G. Severe allergic reaction to allspice, a hidden food allergen. Ann Allergy Asthma Immunol. 2022;129(2):241-2. PubMed

    Regorafenib

    Listed in the ADVERSE REACTIONS section of the FDA label for Regorafenib. Read the label on DailyMed ›

Reported for Allspice but not commonly for Regorafenib: shortness of breath, an allergic reaction, a severe allergic reaction and hives.

Effects for Regorafenib come from the ADVERSE REACTIONS section of its FDA label; effects for Allspice come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 11,442 voluntary FDA FAERS reports for Regorafenib that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Allspice in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of allspice when used in larger amounts as medicine; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Regorafenib

This page covers Allspice only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Regorafenib page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Regorafenib page

“Regorafenib (Stivarga) is a targeted oral cancer therapy, and with a drug like this the goal is keeping its blood level inside a fairly tight window, so the 138 supplements and herbs on this page deserve real respect. Nearly all of them, 121 in total, can shift how the liver enzyme CYP3A4 processes the drug, nudging its level up or down.”

Reviewed by 2 · Jul 18, 2026

Open the Regorafenib interaction page

One more smart check

Taking Allspice as Part of a Dietary Supplement Product? Check It for Interactions

We hold 133 real supplement products containing Allspice, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Allspice. Even though Allspice itself has no known interaction with Regorafenib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Allspice and Regorafenib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Allspice
Top half

#518 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Regorafenib
Steady interest

#1,593 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Allspice reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Allspice and Regorafenib records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Allspice

What is Allspice?

Allspice
  • Digestive upset and gas
  • Muscle and joint pain (topical)
  • Toothache and oral discomfort
  • Antimicrobial uses
  • Flavoring in food and drinks

Allspice is a popular cooking spice from a Caribbean evergreen tree that has long been used in folk medicine for digestion, pain, and infections. There is very little high-quality human research to support these medicinal uses, so it is best thought of as a flavorful food rather than a proven treatment. Amounts used in cooking are generally considered safe, but concentrated extracts and the essential oil should be used carefully.

Pimenta dioica · Myrtaceae · Dried unripe berries, leaves, and essential oil · Whole or ground spice, tea, extract, essential oil

An interaction check asks whether these two react with each other — it does not ask whether Allspice is a good idea for someone in your situation. Here is what our Allspice record says about it on its own.

Allspice: dosing

There is no established standard medicinal dose for allspice. Most people only encounter it in the small amounts used to flavor food, which are considered safe.For supplements, teas, or extracts, there is not enough reliable research to recommend a specific amount. If you choose to use a product, follow the directions on the label and do not exceed them.The essential oil is highly concentrated and should only be used externally and well diluted, never taken by mouth without professional guidance.

From our Allspice monograph — the full record covers uses, side effects and every documented interaction.

Read the full Allspice monograph & all interactions
Medication

About Regorafenib

What Is Regorafenib Used For?

Brand name: Stivarga

Stivarga is approved to treat three types of advanced cancer in adults. It is used for metastatic colorectal cancer (cancer that has spread) after prior chemotherapy and targeted therapy; for locally advanced, unresectable, or metastatic gastrointestinal stromal tumor (GIST) after two previous treatments; and for hepatocellular carcinoma (liver cancer) after treatment with sorafenib.

All three uses are specific to Stivarga tablets taken by mouth. It is intended for patients whose cancer has progressed despite earlier lines of therapy.

Most-Reported Side Effects for Regorafenib

From FAERS, the FDA’s public side-effect reporting system (11,542 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 1,769 reports
Palmar-plantar erythrodysaesthesia syndrome 1,439 reports
Diarrhea 1,418 reports
Decreased appetite 1,091 reports
Asthenia 946 reports
See full Regorafenib drug information
Keep checking

Other Drugs & Allspice

Browse every other medication we’ve checked against Allspice — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Allspice page.

No interaction 2,707 drugs checked — show the list

We also checked Allspice against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Allspice list.

See the full Allspice interactions page
See every supplement checked against Regorafenib, ranked by severity
Evidence & sources

Allspice References

The 5 references that drive our Allspice monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62. PubMed
  3. Chen SJ, Wang MH, Chen IJ. Antiplatelet and calcium inhibitory properties of eugenol and sodium eugenol acetate. Gen Pharmacol 1996;27:629-33. PubMed
  4. Niinimaki, A. Delayed-type allergy to spices. Contact Dermatitis 1984;11(1):34-40. PubMed
  5. Regula P, Edelman D, Ferastraoaru D, Ramesh M, Hudes G. Severe allergic reaction to allspice, a hidden food allergen. Ann Allergy Asthma Immunol. 2022;129(2):241-2. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Allspice and Regorafenib Together: Common Questions

Is it safe to take Allspice with Regorafenib?
We do not list a known interaction between Allspice and Regorafenib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Allspice and Regorafenib have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Allspice and Regorafenib combination checked?
Interactions in our licensed database are recorded against drug classes. Regorafenib is filed under 2 classifications, and Allspice has documented interactions with 1 drug class — none of Regorafenib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Allspice interact with any other medications?
Yes. Allspice has 122 documented drug interactions in our database — Regorafenib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Regorafenib interact with any supplements?
Yes. Regorafenib has documented interactions with 138 supplements in our database — Allspice is not one of them. The Regorafenib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Allspice monograph Uses, safety profile, and every drug interaction in one place Regorafenib drug information The full plain-English guide to this medication Regorafenib supplement interactions Every supplement checked against Regorafenib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Regorafenib and Allspice?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.