Drug & supplement interaction

Aloe + Theobromine

Theobromine brand name: Theobromine.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Aloe has a moderate interaction with Theobromine. Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Aloe and Theobromine

Here is the interaction we found between these two, with the evidence behind it.

Moderate

DIURETIC DRUGS

Why this applies to Theobromine

Theobromine falls under DIURETIC DRUGS — the group Aloe interacts with.

Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for taking aloe alongside theobromine (a mild stimulant and gentle diuretic, related to caffeine and found naturally in cocoa). The concern isn't with the soothing aloe gel you rub on your skin. It's with aloe latex, the yellow part taken by mouth, which acts as a strong laxative. Both that laxative effect and theobromine's mild water-pill action can nudge your body to lose potassium.

Used together heavily, they could in theory add up and drop your potassium too low, which might show up as muscle cramps, weakness, or an irregular heartbeat. Keep in mind this is a theoretical worry based on how they work, not something proven in studies, and only really applies to regular oral aloe latex, not the topical gel. If you take both often, check in with your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Aloe Also Interacts With Other Medications

Aloe has 1 major, 303 moderate, 156 minor known drug interactions in our database — the Theobromine one above is one of them. If you take anything else, check it against the full list below.

Major 1 Moderate 303 Minor 156 No known interaction 2,370 (incl. Theobromine)
Taking anything else?

Check Another of Your Medications Against Aloe

Covers the 2,830 medications we’ve checked against Aloe. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Theobromine

This page covers Aloe only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Theobromine page lists 97 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Mistletoe (major), Ephedra (major), Lithium (major) and Oleander (major).

By severity: 7 major · 75 moderate · 15 minor.

From our pharmacist’s overview on the Theobromine page

“Theobromine, the caffeine cousin found in chocolate and used medically as a mild diuretic and blood vessel relaxer, deserves real care around supplements. Most of the trouble runs through its diuretic action: dozens of herbs, from aloe latex to apple cider vinegar, either add their own fluid-losing effect or drain potassium, and togeth…”

Reviewed by 2 · Jul 18, 2026

Open the Theobromine interaction page

One more smart check

Taking Aloe as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,978 real supplement products containing Aloe, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Aloe. Your product may carry other ingredients that interact with Theobromine too, on top of Aloe — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Aloe and Theobromine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Aloe
Top 10%

#89 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Theobromine
Top half

#1,239 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Aloe

What is Aloe?

Aloe
  • Minor burns and skin irritation
  • Wound healing
  • Constipation
  • Skin hydration and moisturizing
  • Digestive complaints
  • Hair and scalp care

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a strong laxative that can cause cramping and is not considered safe for regular use. Talk to your pharmacist or doctor before taking aloe by mouth, and avoid oral aloe during pregnancy.

Read the full Aloe monograph & all interactions
Keep checking

Other Drugs & Aloe

Browse every other medication we’ve checked against Aloe — both the ones with a known interaction and the ones without. Select any drug for the full detail.

1Major
303Moderate
156Minor
2,369No known interaction
1 Major 303 Moderate 156 Minor 2,369 No interaction
Major

1 interaction

Moderate

303 interactions

Showing 60 of 303 moderate interactions — see all 303 on the Aloe page.

Minor

156 interactions

Showing 60 of 156 minor interactions — see all 156 on the Aloe page.

No interaction 2,369 drugs checked — show the list

We also checked Aloe against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,369 medications checked with no known interaction — see the full Aloe list.

See the full Aloe interactions page
See every supplement checked against Theobromine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Aloe monograph › Uses, safety, and every drug interaction in one place Theobromine supplement interactions › Every supplement checked against Theobromine, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Aloe and Theobromine Together: Common Questions

Can you take Aloe with Theobromine?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Aloe and Theobromine interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Theobromine and Aloe?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.