Drug & supplement interaction

Androstenediol + Acetaminophen, Dexbrompheniramine, Pseudoephedrine

Acetaminophen, Dexbrompheniramine, Pseudoephedrine brand name: Sinadrin Plus.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Androstenediol and Acetaminophen, Dexbrompheniramine, Pseudoephedrine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Androstenediol and Acetaminophen, Dexbrompheniramine, Pseudoephedrine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Acetaminophen, Dexbrompheniramine, Pseudoephedrine and Androstenediol in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Androstenediol safety at a glance

Androstenediol overall Avoid It is a controlled anabolic steroid with hormonal risks and is best avoided unless prescribed and supervised.
Pregnancy Avoid Androgen-like hormones can harm a developing baby, so it should not be used during pregnancy.
Breastfeeding Avoid Hormonal effects on a nursing infant are unknown, so avoid use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Acetaminophen, Dexbrompheniramine, Pseudoephedrine and Androstenediol? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Acetaminophen, Dexbrompheniramine, Pseudoephedrine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Acetaminophen, Dexbrompheniramine, Pseudoephedrine is filed under 13 classifications — including cytochrome p450 2e1 (cyp2e1) substrates, glucuronidated drugs, alpha-adrenergic agonists. Androstenediol has documented interactions with 2 drug classes — the most serious being estrogens (moderate) and testosterone (moderate) — and none of Acetaminophen, Dexbrompheniramine, Pseudoephedrine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Androstenediol Does Interact With Other Medications

Androstenediol has 47 moderate known drug interactions in our database — Acetaminophen, Dexbrompheniramine, Pseudoephedrine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 47 No known interaction 2,783 (incl. Acetaminophen, Dexbrompheniramine, Pseudoephedrine)
Taking anything else?

Check Another of Your Medications Against Androstenediol

Covers the 2,830 medications we’ve checked against Androstenediol. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Acetaminophen, Dexbrompheniramine, Pseudoephedrine

This page covers Androstenediol only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Dexbrompheniramine, Pseudoephedrine page lists 217 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Ephedra (major) and Peyote (major).

By severity: 9 major · 169 moderate · 39 minor.

From our pharmacist’s overview on the Acetaminophen, Dexbrompheniramine, Pseudoephedrine page

“Sinadrin Plus (acetaminophen, dexbrompheniramine, and pseudoephedrine) deserves real care around supplements, mostly because pseudoephedrine is a stimulant and acetaminophen taxes the liver. Nine of the 217 ingredients on file carry a major rating, and they cluster around those two risks: ephedra and similar herbs can pile onto the sti…”

Reviewed by 2 · Jul 18, 2026

Open the Acetaminophen, Dexbrompheniramine, Pseudoephedrine interaction page

How much people look this up

Where Androstenediol and Acetaminophen, Dexbrompheniramine, Pseudoephedrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Androstenediol
Steady interest

#1,091 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetaminophen, Dexbrompheniramine, Pseudoephedrine
Top half

#765 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Androstenediol reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Androstenediol and Acetaminophen, Dexbrompheniramine, Pseudoephedrine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Androstenediol

What is Androstenediol?

Androstenediol
  • Boosting testosterone
  • Building muscle and strength
  • Enhancing athletic performance
  • Anti-aging / general vitality
  • Bodybuilding cutting or bulking cycles

Androstenediol is a prohormone (a precursor the body can convert into testosterone and other hormones) marketed to raise testosterone and build muscle, but solid human evidence for these benefits is lacking and it carries real hormonal risks. In the United States it is a Schedule III controlled substance and is banned in most competitive sports. Talk with a doctor or pharmacist before considering any product containing it.

Not a plant; a steroid hormone (prohormone) made synthetically or naturally in the body · Capsules, tablets, sublingual tablets, sprays (sold as 'prohormone' supplements)

An interaction check asks whether these two react with each other — it does not ask whether Androstenediol is a good idea for someone in your situation. Here is what our Androstenediol record says about it on its own.

Androstenediol: dosing

There is no established safe or effective dose of androstenediol, and because it is a controlled substance, it is not a routine over-the-counter supplement. The body of research does not support a recommended amount.If you are considering any product that contains it, do not rely on label claims.

From our Androstenediol monograph — the full record covers uses, side effects and every documented interaction.

Read the full Androstenediol monograph & all interactions
Keep checking

Other Drugs & Androstenediol

Browse every other medication we’ve checked against Androstenediol — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
47Moderate
0Minor
2,782No known interaction
47 Moderate 2,782 No interaction
Moderate

47 interactions

No interaction 2,782 drugs checked — show the list

We also checked Androstenediol against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,782 medications checked with no known interaction — see the full Androstenediol list.

See the full Androstenediol interactions page
See every supplement checked against Acetaminophen, Dexbrompheniramine, Pseudoephedrine, ranked by severity
Evidence & sources

Androstenediol References

The 3 references that drive our Androstenediol monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Broeder CE, Quindry J, Brittingham K, et al. The Andro Project: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med 2000;160:30
  2. Brown GA, Martini ER, Roberts BS, et al. Acute hormonal response to sublingual androstenediol intake in young men. J Appl Physiol 2002;92:142-6. PubMed
  3. Battista, V., Combs, J., and Warme, W. J. Asynchronous bilateral achilles tendon ruptures and androstenediol use. Am J Sports Med 2003;31(6):1007-1009. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Androstenediol and Acetaminophen, Dexbrompheniramine, Pseudoephedrine Together: Common Questions

Is it safe to take Androstenediol with Acetaminophen, Dexbrompheniramine, Pseudoephedrine?
We do not list a known interaction between Androstenediol and Acetaminophen, Dexbrompheniramine, Pseudoephedrine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Androstenediol and Acetaminophen, Dexbrompheniramine, Pseudoephedrine combination checked?
Interactions in our licensed database are recorded against drug classes. Acetaminophen, Dexbrompheniramine, Pseudoephedrine is filed under 13 classifications, and Androstenediol has documented interactions with 2 drug classes — none of Acetaminophen, Dexbrompheniramine, Pseudoephedrine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Androstenediol interact with any other medications?
Yes. Androstenediol has 47 documented drug interactions in our database — Acetaminophen, Dexbrompheniramine, Pseudoephedrine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Acetaminophen, Dexbrompheniramine, Pseudoephedrine interact with any supplements?
Yes. Acetaminophen, Dexbrompheniramine, Pseudoephedrine has documented interactions with 217 supplements in our database — Androstenediol is not one of them. The Acetaminophen, Dexbrompheniramine, Pseudoephedrine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Androstenediol monograph Uses, safety profile, and every drug interaction in one place Acetaminophen, Dexbrompheniramine, Pseudoephedrine supplement interactions Every supplement checked against Acetaminophen, Dexbrompheniramine, Pseudoephedrine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Acetaminophen, Dexbrompheniramine, Pseudoephedrine and Androstenediol?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.