Drug & supplement interaction

Androstenedione + Felodipine

Felodipine brand names: Plendil, Renedil.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Androstenedione and Felodipine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Felodipine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Androstenedione and Felodipine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Felodipine and Androstenedione in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Androstenedione safety at a glance

Androstenedione overall Avoid It is a controlled substance with hormonal risks and little proven benefit.
Pregnancy Likely Unsafe When used orally. Androstenedione might induce labor. Read the full pregnancy detail
Breastfeeding Avoid It is unsafe and not recommended while breastfeeding.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Felodipine and Androstenedione? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Felodipine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Felodipine is filed under 5 classifications — including calcium channel blockers, antihypertensive drugs, cytochrome p450 3a4 (cyp3a4) substrates. Androstenedione has documented interactions with 1 drug class — the most serious being estrogens (moderate) — and none of Felodipine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Androstenedione Does Interact With Other Medications

Androstenedione has 41 moderate known drug interactions in our database — Felodipine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 41 No known interaction 2,789 (incl. Felodipine)
Taking anything else?

Check Another of Your Medications Against Androstenedione

Covers the 2,830 medications we’ve checked against Androstenedione. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Androstenedione and Felodipine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Low mood Worth acting on Additional detail

    Androstenedione

    “There is some concern that androstenedione might cause or worsen depression in women. Some women with severe major depression seem to have increased endogenous androstenedione concentrations; however, it is not known if supplements can actually cause this adverse effect.”

    Androstenedione · Natural Medicines adverse-effect record, reported in depression.

    1 source cited
    1. 6796. Weber B, Lewicka S, Deuschle M, et al. Testosterone, androstenedione and dihydrotestosterone concentrations are elevated in female patients with major depression. Psychoneuroendocrinology 2000;25:765-71. PubMed

    Felodipine

    Listed in the ADVERSE REACTIONS section of the FDA label for Felodipine. Read the label on DailyMed ›

  • A change in sex drive / Breast tenderness / Erection problems Additional detail

    Androstenedione

    “Orally, androstenedione possibly alters levels of estrogen and testosterone in men. Theoretically, this might cause decreased spermatogenesis, gynecomastia, testicular atrophy, and prostate hypertrophy. There is one case report of two episodes of priapism associated with androstenedione use in a 30-year-old man.”

    Androstenedione · Natural Medicines adverse-effect record, reported in erectile dysfunction (ed).

    6 sources cited
    1. 1905. Broeder CE, Quindry J, Brittingham K, et al. The Andro Project: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med 2000;160:30
    2. 3861. Leder BZ, Longcope C, Catlin DH, et al. Oral androstenedione administration and serum testosterone concentrations in young men. JAMA 2000;283:779-82. PubMed
    3. 6000. King DS, Sharp RL, Vukovich MD, et al. Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men. A randomized controlled trial. JAMA 1999;281:2020-8. PubMed
    4. 7236. Brown GA, Vukovich MD, Martini ER, et al. Endocrine responses to chronic androstenedione intake in 30- to 56-year-old men. J Clin Endocrinol Metab 2000;85:4074-80. DOI
    5. 8138. Brown GA, Vukovich MD, Martini ER, et al. Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old men. Int J Vitam Nutr Res 2001;71:293-301. PubMed
    6. 97845. Judge LW, Bellar DM, Hoover DL, Biggs D, Leitzelar BN, Craig BW. Effects of acute androstenedione supplementation on testosterone levels in older men. Aging Male. 2016;19(3):161-167. PubMed

    Felodipine

    Listed in the ADVERSE REACTIONS section of the FDA label for Felodipine. Read the label on DailyMed ›

Reported for Androstenedione but not commonly for Felodipine: liver problems and acne.

Effects for Felodipine come from the ADVERSE REACTIONS section of its FDA label; effects for Androstenedione come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Androstenedione in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Androstenedione might induce labor.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Felodipine Products Have a Food Rule — Androstenedione Should Not Break It

At least one FDA label for a product containing Felodipine says to take it on an empty stomach. Most supplements — Androstenedione included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Felodipine on its own and move Androstenedione to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Felodipine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Felodipine should regularly be taken either without food or with a light meal (see CLINICAL PHARMACOLOGY, Pharmacokinetics and Metabolism ).

From the Dosage and Administration section of the FDA label we read for Felodipine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Androstenedione or Felodipine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Androstenedione or Felodipine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Felodipine

This page covers Androstenedione only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Felodipine page lists 232 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Coleus (major) and Grapefruit (major).

By severity: 8 major · 182 moderate · 42 minor.

From our pharmacist’s overview on the Felodipine page

“Felodipine (Plendil) is a blood pressure medicine broken down by the CYP3A4 enzyme, which is why 232 supplements and foods have an interaction on file, eight of them rated major. This list deserves real care.”

Reviewed by 2 · Jul 18, 2026

Open the Felodipine interaction page

One more smart check

Taking Androstenedione as Part of a Dietary Supplement Product? Check It for Interactions

We hold 4 real supplement products containing Androstenedione, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Androstenedione. Even though Androstenedione itself has no known interaction with Felodipine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Androstenedione and Felodipine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Androstenedione
Top half

#391 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Felodipine
Top 25%

#415 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Androstenedione reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Androstenedione and Felodipine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Androstenedione

What is Androstenedione?

Androstenedione
  • Muscle building
  • Athletic performance
  • Boosting testosterone
  • Anti-aging
  • Increasing libido

Androstenedione is a prohormone that the body can convert into testosterone and estrogen, but studies have not shown that taking it reliably builds muscle or improves athletic performance. It carries real risks, is a controlled substance in the United States, and is banned in nearly all sports, so most people should avoid it.

Not a plant; a hormone precursor made synthetically or in the body · Capsules, tablets, sublingual sprays, powders (where legally available)

An interaction check asks whether these two react with each other — it does not ask whether Androstenedione is a good idea for someone in your situation. Here is what our Androstenedione record says about it on its own.

Androstenedione: dosing

There is no established safe or effective dose for androstenedione. Past products varied widely, and because it is now a controlled substance, it is not appropriate to recommend any amount.If you encounter a product containing it, do not assume the label dose is safe or accurate. The safest choice is to avoid it.

From our Androstenedione monograph — the full record covers uses, side effects and every documented interaction.

Read the full Androstenedione monograph & all interactions
Medication

About Felodipine

What Is Felodipine Used For?

Brand names: Plendil, Renedil

Felodipine extended-release tablets are used to treat high blood pressure (hypertension). Lowering blood pressure lowers the risk of strokes and heart attacks.

It can be used alone or with other blood pressure medicines. Many people need more than one drug to reach their blood pressure goal.

See full Felodipine drug information
Keep checking

Other Drugs & Androstenedione

Browse every other medication we’ve checked against Androstenedione — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
41Moderate
0Minor
2,788No known interaction
41 Moderate 2,788 No interaction
Moderate

41 interactions

No interaction 2,788 drugs checked — show the list

We also checked Androstenedione against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,788 medications checked with no known interaction — see the full Androstenedione list.

See the full Androstenedione interactions page
See every supplement checked against Felodipine, ranked by severity
Evidence & sources

Androstenedione References

The 21 references that drive our Androstenedione monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. van Weerden WM, van Kreuningen A, Elissen NM, et al. Effects of adrenal androgens on the transplantable human prostate tumor PC-82. Endocrinol 1992;131:2909-13.
  2. Mecenas CA, Giussani DA, Owiny JR, et al. Production of premature delivery in pregnant rhesus monkeys by androstenedione infusion. Nat Med 1996;2:443-8. PubMed
  3. Anon. Creatine and androstenedione, two dietary supplements. Med Lett Drugs Ther 1998;40:105-6.
  4. Broeder CE, Quindry J, Brittingham K, et al. The Andro Project: physiological and hormonal influences of androstenedione supplementation in men 35 to 65 years old participating in a high-intensity resistance training program. Arch Intern Med 2000;160:30
  5. Leder BZ, Longcope C, Catlin DH, et al. Oral androstenedione administration and serum testosterone concentrations in young men. JAMA 2000;283:779-82. PubMed
  6. Kachhi PN, Henderson SO. Priapism after androstenedione intake for athletic performance enhancement. Ann Emerg Med 2000;35:391-3. PubMed
  7. King DS, Sharp RL, Vukovich MD, et al. Effect of oral androstenedione on serum testosterone and adaptations to resistance training in young men. A randomized controlled trial. JAMA 1999;281:2020-8. PubMed
  8. Weber B, Lewicka S, Deuschle M, et al. Testosterone, androstenedione and dihydrotestosterone concentrations are elevated in female patients with major depression. Psychoneuroendocrinology 2000;25:765-71. PubMed
  9. Brown GA, Vukovich MD, Martini ER, et al. Endocrine responses to chronic androstenedione intake in 30- to 56-year-old men. J Clin Endocrinol Metab 2000;85:4074-80. DOI
  10. Brown GA, Vukovich MD, Martini ER, et al. Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old men. Int J Vitam Nutr Res 2001;71:293-301. PubMed
  11. Leder, B. Z., Leblanc, K. M., Longcope, C., Lee, H., Catlin, D. H., and Finkelstein, J. S. Effects of oral androstenedione administration on serum testosterone and estradiol levels in postmenopausal women. J Clin Endocrinol Metab 2002;87(12):5449-5454. PubMed
  12. Brown, G. A., Vukovich, M., and King, D. S. Testosterone prohormone supplements. Med Sci Sports Exerc 2006;38(8):1451-1461. PubMed
  13. Cauley, J. A., Lucas, F. L., Kuller, L. H., Stone, K., Browner, W., and Cummings, S. R. Elevated serum estradiol and testosterone concentrations are associated with a high risk for breast cancer. Study of Osteoporotic Fractures Research Group. Ann Intern PubMed
  14. Kohut, M. L., Thompson, J. R., Campbell, J., Brown, G. A., Vukovich, M. D., Jackson, D. A., and King, D. S. Ingestion of a dietary supplement containing dehydroepiandrosterone (DHEA) and androstenedione has minimal effect on immune function in middle-age
  15. Barrett-Connor, E., Garland, C., McPhillips, J. B., Khaw, K. T., and Wingard, D. L. A prospective, population-based study of androstenedione, estrogens, and prostatic cancer. Cancer Res 1-1-1990;50(1):169-173.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Androstenedione and Felodipine Together: Common Questions

Is it safe to take Androstenedione with Felodipine?
We do not list a known interaction between Androstenedione and Felodipine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Androstenedione and Felodipine have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Androstenedione and Felodipine at the same time of day?
At least one FDA label for a product containing Felodipine says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Felodipine on its own and move Androstenedione to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.
How was the Androstenedione and Felodipine combination checked?
Interactions in our licensed database are recorded against drug classes. Felodipine is filed under 5 classifications, and Androstenedione has documented interactions with 1 drug class — none of Felodipine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Androstenedione interact with any other medications?
Yes. Androstenedione has 41 documented drug interactions in our database — Felodipine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Felodipine interact with any supplements?
Yes. Felodipine has documented interactions with 232 supplements in our database — Androstenedione is not one of them. The Felodipine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Androstenedione monograph Uses, safety profile, and every drug interaction in one place Felodipine drug information The full plain-English guide to this medication Felodipine supplement interactions Every supplement checked against Felodipine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 21 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Felodipine and Androstenedione?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.