Apple Polyphenols - Plaquenil (Hydroxychloroquine) Interaction
Herbal: Apple Polyphenols
Also Known As: Apple Phenolics, Apple Polyphenol Extract, Phloretin, Phlorizin
Drug: Hydroxychloroquine
Brand names:
Plaquenil
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
There were no interactions found between Hydroxychloroquine and Apple Polyphenols. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Apple Polyphenols Overview
Apple polyphenols are phytochemicals extracted from apples, containing compounds such as chlorogenic acid, phlorizin, phloretin, epicatechin, procyanidins, quercetin, and kaempferol. These polyphenols are believed to offer therapeutic benefits primarily through their antioxidant effects. They are commonly used for conditions like hyperlipidemia, hypertension, and obesity, although there's insufficient reliable information to rate their effectiveness for these uses. Apple polyphenols are typically considered safe when used orally, short-term, or topically, with no known major drug interactions. They are absorbed in the gut, with salivary digestion playing a role, and are metabolized via methylation, sulfation, and glucuronidation before being released into the bloodstream.
Hydroxychloroquine Overview
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Hydroxychloroquine is used to prevent and treat acute attacks of malaria in adults and children weighing more than 31 kg (68 lbs). It is also used to treat discoid lupus erythematosus (DLE; a chronic inflammatory condition of the skin) or systemic lupus erythematosus (SLE or lupus; an autoimmune disease in which the immune system attacks healthy parts of the body such as joints, skin, blood vessels, and organs) and rheumatoid arthritis. Hydroxychloroquine is in a class of drugs called antimalarials and is also an antirheumatic drug. It works by killing the organisms that cause malaria. Hydroxychloroquine may work to treat rheumatoid arthritis and systemic lupus erythematosus by decreasing the activity of the immune system.
Apple Polyphenols - More Interactions
Apple Polyphenols interacts with 13 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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