Drug & supplement interaction

Bilberry + Ponesimod

Ponesimod brand name: Ponvory.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Bilberry and Ponesimod in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Bilberry and Ponesimod

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ponesimod and Bilberry in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Bilberry safety at a glance

Bilberry overall Use caution Bilberry fruit is generally safe as food, but supplement evidence and long-term safety are limited.
Pregnancy Likely Safe When used orally in the amounts commonly found in foods. However, there is insufficient reliable information available about the safety of bilberry when used in... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in the amounts commonly found in foods. However, there is insufficient reliable information available about the safety of bilberry when used in... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ponesimod and Bilberry? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ponesimod

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ponesimod is filed under 3 classifications — qt interval-prolonging drugs, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Bilberry has documented interactions with 4 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and cytochrome p450 2e1 (cyp2e1) substrates (moderate) — and none of Ponesimod’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Bilberry Does Interact With Other Medications

Bilberry has 275 moderate known drug interactions in our database — Ponesimod isn’t one of them. If you take anything else, check it against the full list below.

Moderate 275 No known interaction 2,555 (incl. Ponesimod)
Taking anything else?

Check Another of Your Medications Against Bilberry

Covers the 2,830 medications we’ve checked against Bilberry. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Bilberry and Ponesimod May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Stomach upset Additional detail

    Bilberry

    “Orally, bilberry fruit, juice, and extracts seem to be well tolerated.

    Most Common Adverse Effects:

    Orally: Dark-colored stools, flatulence, and gastrointestinal discomfort.”

    Bilberry · Natural Medicines adverse-effect record, reported in flatulence.

    Ponesimod

    Listed in the ADVERSE REACTIONS section of the FDA label for Ponesimod. Read the label on DailyMed ›

Reported for Bilberry but not commonly for Ponesimod: memory problems, bloating or gas, heartburn and nausea.

Effects for Ponesimod come from the ADVERSE REACTIONS section of its FDA label; effects for Bilberry come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Bilberry in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in the amounts commonly found in foods. However, there is insufficient reliable information available about the safety of bilberry when used in medicinal amounts during pregnancy and lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Ponesimod

This page covers Bilberry only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ponesimod page lists 146 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 8 major · 98 moderate · 40 minor.

From our pharmacist’s overview on the Ponesimod page

“Someone managing relapsing MS with ponesimod (Ponvory) has real reason to read this list closely, since 8 of its 146 documented supplement interactions rate major. The largest group, 121 ingredients, works through CYP3A4, the liver enzyme that clears ponesimod.”

Reviewed by 2 · Jul 18, 2026

Open the Ponesimod interaction page

One more smart check

Taking Bilberry as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3,883 real supplement products containing Bilberry, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Bilberry. Even though Bilberry itself has no known interaction with Ponesimod, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Bilberry and Ponesimod Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Bilberry
Top 10%

#81 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ponesimod
Top half

#898 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Bilberry reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Bilberry and Ponesimod records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Bilberry

What is Bilberry?

Bilberry
  • Eye and vision health
  • Antioxidant support
  • Diarrhea and digestive upset
  • Circulation and vein health
  • Blood sugar support

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While it is generally well tolerated as a food and supplement, strong scientific proof for most health claims is limited. Talk with your pharmacist or doctor before using bilberry supplements, especially if you are pregnant, breastfeeding, or have a health condition.

Vaccinium myrtillus · Ericaceae · Berries (fruit) and sometimes leaves · Capsules, tablets, standardized extracts, dried berries, tea, liquid extracts

An interaction check asks whether these two react with each other — it does not ask whether Bilberry is a good idea for someone in your situation. Here is what our Bilberry record says about it on its own.

Bilberry: dosing

There is no single official or standardized dose of bilberry. Studies have used different forms and amounts, often using extracts standardized to a certain percentage of anthocyanins.Because products vary widely in strength, it is best to follow the directions on the product label and not exceed the recommended amount.

From our Bilberry monograph — the full record covers uses, side effects and every documented interaction.

Read the full Bilberry monograph & all interactions
Medication

About Ponesimod

What Is Ponesimod Used For?

Brand name: Ponvory

Ponvory (ponesimod) is approved for adults with relapsing forms of multiple sclerosis (MS). This includes clinically isolated syndrome (a first MS episode), relapsing-remitting MS, and active secondary progressive MS.

It is not approved for children, and it is only available as an oral tablet under the brand name Ponvory.

Most-Reported Side Effects for Ponesimod

From FAERS, the FDA’s public side-effect reporting system (428 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fatigue 35 reports
Dizziness 24 reports
Dyspnea 23 reports
Headache 22 reports
Nausea 14 reports
See full Ponesimod drug information
Keep checking

Other Drugs & Bilberry

Browse every other medication we’ve checked against Bilberry — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
275Moderate
0Minor
2,554No known interaction
275 Moderate 2,554 No interaction
Moderate

275 interactions

Showing 60 of 275 moderate interactions — see all 275 on the Bilberry page.

No interaction 2,554 drugs checked — show the list

We also checked Bilberry against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,554 medications checked with no known interaction — see the full Bilberry list.

See the full Bilberry interactions page
See every supplement checked against Ponesimod, ranked by severity
Evidence & sources

Bilberry References

The 14 references that drive our Bilberry monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
  2. Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 1990;61:13-21.
  3. Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. PubMed
  4. Hawrelak, J. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 2010;16(10):1065-1071. PubMed
  5. Morazzoni P and Magistretti MJ. Effects of Vaccinium myrtillus anthocyanosides on prostacyclin-like activity in rat arterial issue. Fitoterapia 1986;57:11-14.
  6. Pulliero G, Montin S, Bettini V, and et al. Ex vivo study of the inhibitory effects of Vaccinium myrtillus anthocyanosides on human platelet aggregation. Fitoterapia 1989;60:69-75.
  7. Bottecchia D. Preliminary report on the inhibitory effect of vaccinium myrtillus anthocyanosides on platelet aggregation and clot retraction. Fitoterapia 1987;48:3-8.
  8. Fdez, M., Zaragoza, F., and Alvarez, P. In vitro platelet aggregation effects of anthocyanosides of vaccinium myrtilus L. Anales de la Real Academia de Farmacia 1983;49:79-90.
  9. Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis-an open pilot study. 2013 May;7(4):271-9. PubMed
  10. Hoggard N, Cruickshank M, Moar KM, Bestwick C, Holst J, Russell W, et al. A single supplement of a standardized bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes control
  11. Aichinger G, Pahlke G, Nagel LJ, Berger W, Marko D. Bilberry extract, its major phenolic compounds, and soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells. Food Funct 2016;7(8):3628-36.
  12. Prokop J, Lněničková K, Cibicek N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019;129:382-90. PubMed
  13. Chan SW, Chu TTW, Choi SW, Benzie IFF, Tomlinson B. Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res 2021. Online ahead o PubMed
  14. Bøhn SK, Myhrstad MCW, Thoresen M, et al. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr 2021;7(1):75. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Bilberry and Ponesimod Together: Common Questions

Is it safe to take Bilberry with Ponesimod?
We do not list a known interaction between Bilberry and Ponesimod. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Bilberry and Ponesimod have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Bilberry and Ponesimod combination checked?
Interactions in our licensed database are recorded against drug classes. Ponesimod is filed under 3 classifications, and Bilberry has documented interactions with 4 drug classes — none of Ponesimod's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Bilberry interact with any other medications?
Yes. Bilberry has 275 documented drug interactions in our database — Ponesimod is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ponesimod interact with any supplements?
Yes. Ponesimod has documented interactions with 146 supplements in our database — Bilberry is not one of them. The Ponesimod interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Bilberry monograph Uses, safety profile, and every drug interaction in one place Ponesimod drug information The full plain-English guide to this medication Ponesimod supplement interactions Every supplement checked against Ponesimod, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 14 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ponesimod and Bilberry?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.