Drug & supplement interaction

Black Seed + Netarsudil

Netarsudil brand name: Rhopressa.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Black Seed and Netarsudil in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Black Seed and Netarsudil

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Netarsudil and Black Seed in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Black Seed safety at a glance

Black Seed overall Use caution Likely safe in food amounts, but higher supplement doses are less studied long-term.
Pregnancy Likely Unsafe When used orally in amounts exceeding those found in food. Black seed may decrease or inhibit uterine contractions and may have contraceptive activity. Read the full pregnancy detail
Breastfeeding Use caution Not enough reliable safety information, so it is best to avoid supplement doses.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Netarsudil and Black Seed? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Black Seed Does Interact With Other Medications

Black Seed has 912 moderate known drug interactions in our database — Netarsudil isn’t one of them. If you take anything else, check it against the full list below.

Moderate 912 No known interaction 1,918 (incl. Netarsudil)
Taking anything else?

Check Another of Your Medications Against Black Seed

Covers the 2,830 medications we’ve checked against Black Seed. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Black Seed and Netarsudil May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Bleeding or bruising Worth acting on Additional detail

    Black Seed

    “Orally, relatively severe menstrual bleeding has occurred in one clinical trial.”

    Black Seed · Natural Medicines adverse-effect record, reported in bleeding.

    1 source cited
    1. 104661. Safi S, Razmpoosh E, Fallahzadeh H, et al. The effect of Nigella sativa on appetite, anthropometric and body composition indices among overweight and obese women: A crossover, double-blind, placebo-controlled, randomized clinical trial. Complement Ther Me PubMed

    Netarsudil

    Listed in the ADVERSE REACTIONS section of the FDA label for Netarsudil. Read the label on DailyMed ›

Reported for Black Seed but not commonly for Netarsudil: a severe skin reaction, stomach upset, kidney problems and liver problems.

Effects for Netarsudil come from the ADVERSE REACTIONS section of its FDA label; effects for Black Seed come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Black Seed in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally in amounts exceeding those found in food. Black seed may decrease or inhibit uterine contractions and may have contraceptive activity.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Netarsudil Is Prescribed For, and What Black Seed Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Netarsudil is a prescription medicine with approved uses on its FDA label. Black Seed is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Netarsudil is prescribed for: Rhopressa (netarsudil ophthalmic solution) is used to reduce elevated intraocular pressure (IOP) — the pressure inside the eye — in adults with open-angle glaucoma or ocular hypertension. Both conditions involve higher-than-normal eye pressure that, if left untreated, can damage vision over time.

Black Seed has been studied for:

  • Hypertension Natural Medicines rates the evidence for Black Seed: Possibly Effective Read what the research shows

    Black Seed for hypertension

    Oral black seed powder and black seed oil seem to reduce blood pressure by a small amount. However, if it is unclear if taking black seed is beneficial in patients with hypertension.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Netarsudil on your own; if you are taking Black Seed for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Black Seed or Netarsudil

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Black Seed or Netarsudil, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

One more smart check

Taking Black Seed as Part of a Dietary Supplement Product? Check It for Interactions

We hold 226 real supplement products containing Black Seed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Black Seed. Even though Black Seed itself has no known interaction with Netarsudil, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Black Seed and Netarsudil Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Black Seed
Top 25%

#190 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Netarsudil
Top 10%

#273 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Black Seed reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Black Seed and Netarsudil records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Black Seed

What is Black Seed?

Black Seed
  • Respiratory support (asthma, allergies, cough)
  • Digestive upset
  • Immune support
  • Blood sugar and cholesterol support
  • General inflammation

Black seed (Nigella sativa) is a traditional spice and remedy that has been studied for asthma, blood sugar, cholesterol, and blood pressure, with early research showing some promise but no firmly proven benefits. It is generally well tolerated in food amounts, but supplement-strength doses are less studied, so talk to your pharmacist or doctor before using it—especially if you are pregnant, breastfeeding, or take other medicines.

Nigella sativa · Ranunculaceae · Seeds and the oil pressed from the seeds · Whole seeds, ground powder, capsules, softgels, and cold-pressed oil

An interaction check asks whether these two react with each other — it does not ask whether Black Seed is a good idea for someone in your situation. Here is what our Black Seed record says about it on its own.

Black Seed: dosing

There is no official, standardized dose for black seed. Studies have used a wide range of amounts of seed powder or oil, and products vary a lot in strength.The safest approach is to follow the directions on the product label and start with the lowest suggested amount.

From our Black Seed monograph — the full record covers uses, side effects and every documented interaction.

Read the full Black Seed monograph & all interactions
Medication

About Netarsudil Ophthalmic

What Is Netarsudil Ophthalmic Used For?

Brand name: Rhopressa

Rhopressa (netarsudil ophthalmic solution) is used to reduce elevated intraocular pressure (IOP) — the pressure inside the eye — in adults with open-angle glaucoma or ocular hypertension. Both conditions involve higher-than-normal eye pressure that, if left untreated, can damage vision over time.

See full Netarsudil Ophthalmic drug information
Keep checking

Other Drugs & Black Seed

Browse every other medication we’ve checked against Black Seed — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
912Moderate
0Minor
1,917No known interaction
912 Moderate 1,917 No interaction
Moderate

912 interactions

Showing 60 of 912 moderate interactions — see all 912 on the Black Seed page.

No interaction 1,917 drugs checked — show the list

We also checked Black Seed against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,917 medications checked with no known interaction — see the full Black Seed list.

See the full Black Seed interactions page
See every supplement checked against Netarsudil, ranked by severity
Evidence & sources

Black Seed References

The 60 references that drive our Black Seed monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Aqel M, Shaheen R. Effects of the volatile oil of black seed seeds on the uterine smooth muscle of rat and guinea pig. J Ethnopharmacol 1996;52:23-6.
  3. Keshri G, Singh MM, Lakshmi V, Kamboj VP. Post-coital contraceptive efficacy of the seeds of Black seed in rats. Indian J Physiol Pharmacol 1995;39:59-62.
  4. Tennekoon KH, Jeevathayaparan S, Kurukulasooriya AP, Karunanayake EH. Possible hepatotoxicity of Nigella sativa seeds and Dregea volubilis leaves. J Ethnopharmacol 1991;31:283-9. PubMed
  5. Dehkordi FR, Kamkhah AF. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam Clin Pharmacol 2008;22:447-52.
  6. Zaoui, A., Cherrah, Y., Lacaille-Dubois, M. A., Settaf, A., Amarouch, H., and Hassar, M. [Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat]. Therapie 2000;55(3):379-382.
  7. Enomoto, S., Asano, R., Iwahori, Y., Narui, T., Okada, Y., Singab, A. N., and Okuyama, T. Hematological studies on black cumin oil from the seeds of Nigella sativa L. Biol.Pharm.Bull 2001;24(3):307-310. PubMed
  8. Meral, I., Yener, Z., Kahraman, T., and Mert, N. Effect of Nigella sativa on glucose concentration, lipid peroxidation, anti-oxidant defence system and liver damage in experimentally-induced diabetic rabbits. J Vet.Med A Physiol Pathol.Clin Med 2001;48(1
  9. Al Jishi, S. A. and Abuo, Hozaifa B. Effect of Nigella sativa on blood hemostatic function in rats. J Ethnopharmacol. 2003;85(1):7-14. PubMed
  10. Ali, B. H. and Blunden, G. Pharmacological and toxicological properties of Nigella sativa. Phytother.Res. 2003;17(4):299-305.
  11. Al Naggar, T. B., Gomez-Serranillos, M. P., Carretero, M. E., and Villar, A. M. Neuropharmacological activity of Nigella sativa L. extracts. J Ethnopharmacol. 2003;88(1):63-68. PubMed
  12. Kalus, U., Pruss, A., Bystron, J., Jurecka, M., Smekalova, A., Lichius, J. J., and Kiesewetter, H. Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother.Res. 2003;17(10):1209-1214.
  13. Islam, S. N., Begum, P., Ahsan, T., Huque, S., and Ahsan, M. Immunosuppressive and cytotoxic properties of Nigella sativa. Phytother.Res. 2004;18(5):395-398.
  14. Fararh, K. M., Atoji, Y., Shimizu, Y., Shiina, T., Nikami, H., and Takewaki, T. Mechanisms of the hypoglycaemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocin-induced diabetic hamsters. Res Vet.Sci 2004;77(2):123-129. PubMed
  15. Awad, E. M. and Binder, B. R. In vitro induction of endothelial cell fibrinolytic alterations by Nigella sativa. Phytomedicine 2005;12(3):194-202. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Black Seed and Netarsudil Together: Common Questions

Is it safe to take Black Seed with Netarsudil?
We do not list a known interaction between Black Seed and Netarsudil. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Black Seed and Netarsudil have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Black Seed and Netarsudil used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Black Seed in each. That is a conversation for your prescriber, especially if Netarsudil is being adjusted to a target.
Does Black Seed interact with any other medications?
Yes. Black Seed has 912 documented drug interactions in our database — Netarsudil is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Black Seed monograph Uses, safety profile, and every drug interaction in one place Netarsudil Ophthalmic drug information The full plain-English guide to this medication Netarsudil supplement interactions Every supplement checked against Netarsudil, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 60 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Netarsudil and Black Seed?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.