Drug & supplement interaction

Blood Irradiation Therapy + Alpelisib

Alpelisib brand name: Piqray.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Oct 4, 2026

The bottom line No known interaction

We found no known interaction between Blood Irradiation Therapy and Alpelisib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Blood Irradiation Therapy and Alpelisib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Alpelisib and Blood Irradiation Therapy in our sources. This does not guarantee that the combination is completely free of risk — research on Blood Irradiation Therapy alongside specific medications may be limited.

Blood Irradiation Therapy is a treatment rather than something you take. Tell whoever provides it which medicines you use, and ask your prescriber whether it is appropriate for your health and treatment. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Blood Irradiation Therapy safety at a glance

Blood Irradiation... overall Use caution This is an invasive procedure with infection and other risks, and it is not a proven treatment for most conditions.

Pregnancy Avoid Safety during pregnancy has not been established, so it is best avoided.

Breastfeeding Avoid There is no reliable safety data during breastfeeding, so avoid it.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Alpelisib and Blood Irradiation Therapy? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Alpelisib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Alpelisib is filed under 3 classifications — cytochrome p450 2c9 (cyp2c9) inducers, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Blood Irradiation Therapy has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and immunosuppressants (moderate) — and none of Alpelisib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Blood Irradiation Therapy Does Interact With Other Medications

Blood Irradiation Therapy has 327 moderate known drug interactions in our database — Alpelisib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 327 No known interaction 2,503 (incl. Alpelisib)

Taking anything else?

Check Another of Your Medications Against Blood Irradiation Therapy

Covers the 2,830 medications we’ve checked against Blood Irradiation Therapy. Pick one to open its full report.

What to actually watch for

What Blood Irradiation Therapy Itself Has Been Linked To

This is not an interaction — nothing below involves Alpelisib. It is the side-effect record for Blood Irradiation Therapy on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Blood Irradiation Therapy, this list is the first place to look. 4 entries are worth acting on rather than waiting out — marked below.

Low blood sugar Worth acting on Additional detail
“There is currently a limited amount of information on the adverse effects of blood irradiation therapy. Case reports suggest that it may cause hypotension, urticaria, hypoglycemia, nasal bleeding, rigor, and bronchospasm.”

Blood Irradiation Therapy · Natural Medicines adverse-effect record, reported in hypotension.
1 source cited

27858. Marochkov AV, Doronin VA, Kravtsov NN. [Complications in ultraviolet irradiation of the blood]. Anesteziol Reanimatol 1990;(4):55-6.
“One case report suggests that blood irradiation therapy may cause hypoglycemia. Preliminary clinical research shows that intravascular blood irradiation therapy reduces blood glucose levels in some people.”

Blood Irradiation Therapy · Natural Medicines adverse-effect record, reported in hypoglycemia.
2 sources cited

27858. Marochkov AV, Doronin VA, Kravtsov NN. [Complications in ultraviolet irradiation of the blood]. Anesteziol Reanimatol 1990;(4):55-6.

27857. Kazemi Khoo N, Iravani A, Arjmand M, et al. A metabolomic study on the effect of intravascular laser blood irradiation on type 2 diabetic patients. Lasers Med Sci 2013;28(6):1527-32. PubMed
Wheezing Worth acting on Additional detail

Recorded for Blood Irradiation Therapy in the same Natural Medicines adverse-effect record shown under Low blood sugar above.
Hives Worth acting on Additional detail
“One case report suggests that blood irradiation therapy may cause urticaria.”

Blood Irradiation Therapy · Natural Medicines adverse-effect record, reported in urticaria.
1 source cited

27858. Marochkov AV, Doronin VA, Kravtsov NN. [Complications in ultraviolet irradiation of the blood]. Anesteziol Reanimatol 1990;(4):55-6.
Bleeding or bruising Worth acting on Additional detail
“Case reports suggest that blood irradiation therapy may cause nasal bleeding.”

Blood Irradiation Therapy · Natural Medicines adverse-effect record, reported in bleeding.
1 source cited

27858. Marochkov AV, Doronin VA, Kravtsov NN. [Complications in ultraviolet irradiation of the blood]. Anesteziol Reanimatol 1990;(4):55-6.
Low blood pressure Additional detail
“Case reports suggest that blood irradiation therapy may cause hypotension.”

Blood Irradiation Therapy · Natural Medicines adverse-effect record, reported in hypotension.
1 source cited

27858. Marochkov AV, Doronin VA, Kravtsov NN. [Complications in ultraviolet irradiation of the blood]. Anesteziol Reanimatol 1990;(4):55-6.
Joint pain Additional detail
“Case reports suggest that blood irradiation therapy may cause rigor. Preliminary clinical research suggests that intravascular blood irradiation therapy may exacerbate the inflammatory process in some patients with rheumatoid arthritis.”

Blood Irradiation Therapy · Natural Medicines adverse-effect record, reported in rheumatoid arthritis (ra).
2 sources cited

27858. Marochkov AV, Doronin VA, Kravtsov NN. [Complications in ultraviolet irradiation of the blood]. Anesteziol Reanimatol 1990;(4):55-6.

27867. Zvereva KV, Gladkova ND, Grunina EA, Logunov PL. [The choice of the method for intravascular laser therapy in rheumatoid arthritis]. Ter Arkh 1994;66(1):29-32.

Everything above comes from the Natural Medicines adverse-effect record for Blood Irradiation Therapy — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Alpelisib’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Alpelisib column appears here.

Everything else you take

See Every Supplement That Interacts With Alpelisib

This page covers Blood Irradiation Therapy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Alpelisib page lists 139 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 96 moderate · 40 minor.

From our pharmacist’s overview on the Alpelisib page

“Alpelisib (Piqray) treats PIK3CA-mutated breast cancer, and a drug doing that job leaves little room for supplements that shift its blood level. Yet that is what most of this list does: 121 of the 139 ingredients on file can raise or lower alpelisib through CYP3A4, the liver enzyme that clears it.”

Reviewed by 2 · Jul 18, 2026

Open the Alpelisib interaction page

How much people look this up

Where Blood Irradiation Therapy and Alpelisib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Blood Irradiation Therapy

Steady interest

#753 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Alpelisib

Top half

#1,216 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Blood Irradiation Therapy reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Blood Irradiation Therapy and Alpelisib records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Treatment approach

About Blood Irradiation Therapy

What is Blood Irradiation Therapy?

Chronic infections
Immune support
Fatigue and general wellness
Inflammatory conditions
Circulatory complaints

Blood Irradiation Therapy is a medical procedure—not a dietary supplement or herb—in which blood is exposed to ultraviolet or laser light, either outside the body and re-infused or by an intravenous light device. It is not approved by the U.S. FDA for treating any disease, and high-quality evidence supporting modern claims is very limited. If you are considering it, talk with a qualified physician and treat any clinic marketing it for serious illness with strong caution.

Whole blood (drawn and re-infused, or treated within the body) · Ultraviolet blood irradiation (UBI), intravenous laser blood irradiation, photodynamic procedures performed in clinics

An interaction check asks whether these two react with each other — it does not ask whether Blood Irradiation Therapy is a good idea for someone in your situation. Here is what our Blood Irradiation Therapy record says about it on its own.

Blood Irradiation Therapy: dosing

There is no standardized, scientifically established dose or protocol for Blood Irradiation Therapy. Clinics vary widely in the light source used, the amount of blood treated, the length of exposure, and how many sessions are recommended.Because this is a procedure rather than a pill or supplement, there is no label dose to follow.

From our Blood Irradiation Therapy monograph — the full record covers uses, side effects and every documented interaction.

Read the full Blood Irradiation Therapy monograph & all interactions

Medication

About Alpelisib

What Is Alpelisib Used For?

Brand name: Piqray

Piqray is used with fulvestrant to treat adults with advanced or metastatic breast cancer that is hormone receptor (HR)-positive, HER2-negative and PIK3CA-mutated. It is for use after the cancer has progressed on or after an endocrine-based (hormone-blocking) treatment. An FDA-approved test must detect the mutation.

Vijoice is used for adults and children 2 years and older with severe PROS who need systemic (whole-body) therapy. This use has accelerated approval, which is based on response rate and duration of response. Continued approval may depend on confirmatory trials.

Most-Reported Side Effects for Alpelisib

From FAERS, the FDA’s public side-effect reporting system (8,666 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hyperglycaemia 1,509 reports

Rash 1,391 reports

Diarrhea 1,356 reports

Blood glucose increased 1,130 reports

Nausea 861 reports

See full Alpelisib drug information

Keep checking

Other Drugs & Blood Irradiation Therapy

Browse every other medication we’ve checked against Blood Irradiation Therapy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

327Moderate

0Minor

2,502No known interaction

327 Moderate 2,502 No interaction

Moderate

327 interactions

Showing 60 of 327 moderate interactions — see all 327 on the Blood Irradiation Therapy page.

No interaction 2,502 drugs checked — show the list

We also checked Blood Irradiation Therapy against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,502 medications checked with no known interaction — see the full Blood Irradiation Therapy list.

See the full Blood Irradiation Therapy interactions page

See every supplement checked against Alpelisib, ranked by severity

Evidence & sources

Blood Irradiation Therapy References

The 21 references that drive our Blood Irradiation Therapy monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Nikitin AV, Kashin AV, Karpukhina EP. [Correction of antioxidant defense in patients with bronchial asthma by the method of intravascular laser irradiation]. Probl Tuberk 1993;(3):46-7.
Bobrov VA, Sirenko IuN, Sychev OS, Malinovskaia IE. [Effects of laser irradiation of blood on electrical ventricular instability in patients with progressive angina pectoris]. Kardiologiia 1993;33(2):19-21.
Malinovskaia IE, Sirenko IuN, Shchumakov VA, et al. [Holter monitoring in assessing the efficacy of quantum hemotherapy in patients with unstable stenocardia]. Ter Arkh 1991;63(8):45-8.
Kazemi Khoo N, Iravani A, Arjmand M, et al. A metabolomic study on the effect of intravascular laser blood irradiation on type 2 diabetic patients. Lasers Med Sci 2013;28(6):1527-32. PubMed
Marochkov AV, Doronin VA, Kravtsov NN. [Complications in ultraviolet irradiation of the blood]. Anesteziol Reanimatol 1990;(4):55-6.
Neimark AI, Muzalevskaia NI, Neimark BA. [Prospects for preoperative low-intensity laser therapy in preventing postoperative thrombohemorrhagic complications in adenomectomy]. Urologiia 2002;(5):4-5.
Avrutskii MI, Katkovskii DG, Musikhin LV, et al. [[The use of intravenous low-intensity laser irradiation of the blood in the total complex of anesthesiological protection of patients against surgical stress]. Anesteziol Reanimatol 1991;(2):3-6.
Chepik EB, Shamanova MG, Medvedeva EV, et al. Photochemotherapy in the treatment of acute pneumonias]. Vestn Ross Akad Med Nauk 1994;(9):48-51.
Kuvshinchikova VN, Shmelev EI, Mishin VI. [Effectiveness of extracorporeal ultraviolet blood irradiation in treatment of chronic obstructive bronchitis in pulmonary tuberculosis]. Probl Tuberk 1998;(3):48-50.
Kuvshinchikova VN, Selina LG, Shmelev EI. [Effectiveness of extracorporeal ultraviolet blood irradiation in patients with chronic obstructive bronchitis]. Probl Tuberk 1998;(1):42-4.
Zvereva KV, Gladkova ND, Grunina EA, Logunov PL. [The choice of the method for intravascular laser therapy in rheumatoid arthritis]. Ter Arkh 1994;66(1):29-32.
Vakhrushev IaM, Shkatova EI. [Therapeutic efficiency of a combined use of low-intensity laser radiation and actovegin in gastroduodenal ulcers with inhibited cicatrix formation]. Ter Arkh 2003;75(9):86-9.
Opanasiuk ND, Degtiareva II, Skopichenko SV, et al. [The use of the immunomodulating action of intravascular laser irradiation of the blood in treating peptic ulcer patients]. Lik Sprava 1992;(1):66-8.
Subbotina LA, Radchenko SN, Golovkina OL, Bubeev IuA. [Hemoaggregation dynamics in human-operator during percutaneous laser blood irradiation]. Aviakosm Ekolog Med 2009;43(3):56-60.
Ovcharova AP. [The quantum gravitational therapy of myocarditis]. Lik Sprava 1999;(3):95-7.
Tkachenko IuIa, Kovalenko NN, Kogosova LS, et al. [The clinico-immunological characteristics of bronchial asthma patients undergoing autologous ultraviolet blood irradiation]. Lik Sprava 1993;(8):59-62.
Gorskova VA, Evmenov VF, Zaitseva TS, et al. [Effects of surgical intervention and intravascular irradiation of blood with helium-neon laser on the state humoral autoimmunity in oncological patients]. Khirurgiia (Mosk) 1991;(9):92-8.
Xiao X, Chu X, Ni J. [Effect of intravascular laser irradiation of blood and traditional Chinese medical therapy on immune function in senile cerebral infarction patients of kidney deficiency type]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2000;20(4):264-6.
Nazarov IP, Popov AA, Mal'tseva MA, et al. [State of neuroendocrine systems and immunity in patients with burns]. Anesteziol Reanimatol 1994;(1):5-8.
Neimark AI, Muzalevskaia NI. [Low-intensity laser radiation in preoperative preparation of patients with benign prostatic hyperplasia]. Urologiia 2000;(1):11-5.
Chernushenko EF, Dziublik AI, Naida IV, et al. [Effects of intravascular laser irradiation of blood on the immune status of patients with bronchial obstructive diseases of the lungs]. Klin Med (Mosk) 1991;69(12):51-3.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Having Blood Irradiation Therapy While Taking Alpelisib: Common Questions

Is it safe to have Blood Irradiation Therapy while taking Alpelisib?

We do not list a known interaction between Blood Irradiation Therapy and Alpelisib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Blood Irradiation Therapy and Alpelisib combination checked?

Interactions in our licensed database are recorded against drug classes. Alpelisib is filed under 3 classifications, and Blood Irradiation Therapy has documented interactions with 3 drug classes — none of Alpelisib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Blood Irradiation Therapy interact with any other medications?

Yes. Blood Irradiation Therapy has 327 documented drug interactions in our database — Alpelisib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Alpelisib interact with any supplements?

Yes. Alpelisib has documented interactions with 139 supplements in our database — Blood Irradiation Therapy is not one of them. The Alpelisib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Blood Irradiation Therapy monograph Uses, safety profile, and every drug interaction in one place Alpelisib drug information The full plain-English guide to this medication Alpelisib supplement interactions Every supplement checked against Alpelisib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 21 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Alpelisib and Blood Irradiation Therapy?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.