Drug & supplement interaction

Blue Cohosh + Liraglutide Recombinant

Liraglutide Recombinant brand name: Saxenda.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Blue Cohosh has a moderate interaction with Liraglutide Recombinant. There is some concern that blue cohosh might increase blood glucose levels.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Blue Cohosh and Liraglutide Recombinant

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Liraglutide Recombinant

Liraglutide Recombinant falls under ANTIDIABETES DRUGS — the group Blue Cohosh interacts with.

There is some concern that blue cohosh might increase blood glucose levels. Theoretically, it might decrease the effectiveness of medicines used for diabetes. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist if you're using liraglutide (Saxenda or Victoza) to manage your blood sugar or weight. Blue cohosh is thought to possibly nudge blood sugar upward. Since liraglutide works to bring your numbers down, the worry is that this herb could push in the opposite direction and make your medication seem less effective. You might notice your sugars running higher than usual.

I want to be honest about how solid this is: it's a theoretical concern based on how the herb may behave, not on real studies in people taking liraglutide. Still, blue cohosh has real safety red flags of its own, especially for the heart and in pregnancy. Before mixing the two, please check with your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
  2. Scott, C. C. and Chen, K. K. The pharmacological action of N-methylcytisine. The Journal of Pharmacology and Experimental Therapuetics 1943;79:334-339. DOI

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Blue Cohosh Also Interacts With Other Medications

Blue Cohosh has 258 moderate known drug interactions in our database — the Liraglutide Recombinant one above is one of them. If you take anything else, check it against the full list below.

Moderate 258 No known interaction 2,572 (incl. Liraglutide Recombinant)
Taking anything else?

Check Another of Your Medications Against Blue Cohosh

Covers the 2,830 medications we’ve checked against Blue Cohosh. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Liraglutide Recombinant

This page covers Blue Cohosh only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Liraglutide Recombinant page lists 239 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate), Agaricus Mushroom (moderate) and Agmatine (moderate).

By severity: 1 major · 208 moderate · 30 minor.

From our pharmacist’s overview on the Liraglutide Recombinant page

“If you take liraglutide (Saxenda), handle this page with real care, because all 239 ingredients on it act on the same thing the drug does, your blood sugar. The one major entry, Siberian cocklebur, has caused severe hypoglycemia, dangerously low blood sugar, in people and should never be combined with a glucose-lowering medicine.”

Reviewed by 2 · Jul 18, 2026

Open the Liraglutide Recombinant interaction page

One more smart check

Taking Blue Cohosh as Part of a Dietary Supplement Product? Check It for Interactions

We hold 126 real supplement products containing Blue Cohosh, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Blue Cohosh. Your product may carry other ingredients that interact with Liraglutide Recombinant too, on top of Blue Cohosh — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Blue Cohosh and Liraglutide Recombinant Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Blue Cohosh
Steady interest

#1,076 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Liraglutide Recombinant
Top 10%

#259 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Blue Cohosh

What is Blue Cohosh?

  • Inducing labor or starting menstruation
  • Menstrual cramps and irregular periods
  • Symptoms of menopause
  • Pelvic or uterine discomfort
  • Traditional Native American remedy

Blue cohosh is a traditional herb historically used by Native Americans and midwives to bring on labor or menstruation, but it carries serious safety concerns, especially for the heart and during pregnancy. There is very little reliable human evidence that it works, and reports of harm—including serious problems in newborns—make it an herb most people should avoid without close professional supervision.

Read the full Blue Cohosh monograph & all interactions
Medication

About Liraglutide Injection

What Is Liraglutide Injection Used For?

Brand name: Saxenda

Saxenda is used alongside a reduced-calorie diet and increased physical activity for chronic weight management. It is approved for adults with a BMI of 30 or higher, or a BMI of 27 or higher if they also have at least one weight-related condition such as high blood pressure, type 2 diabetes, or dyslipidemia (abnormal cholesterol or fat levels). It is also approved for adolescents aged 12 and older who weigh more than 60 kg and meet certain BMI thresholds for obesity.

Saxenda should not be used together with other liraglutide-containing products or any other GLP-1 receptor agonist. Its safety and effectiveness in combination with other prescription or over-the-counter weight-loss products have not been established.

See full Liraglutide Injection drug information
Keep checking

Other Drugs & Blue Cohosh

Browse every other medication we’ve checked against Blue Cohosh — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
258Moderate
0Minor
2,571No known interaction
258 Moderate 2,571 No interaction
Moderate

258 interactions

Showing 60 of 258 moderate interactions — see all 258 on the Blue Cohosh page.

No interaction 2,571 drugs checked — show the list

We also checked Blue Cohosh against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,571 medications checked with no known interaction — see the full Blue Cohosh list.

See the full Blue Cohosh interactions page
See every supplement checked against Liraglutide Recombinant, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Blue Cohosh monograph › Uses, safety, and every drug interaction in one place Liraglutide Recombinant supplement interactions › Every supplement checked against Liraglutide Recombinant, ranked by severity Liraglutide Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Blue Cohosh and Liraglutide Recombinant Together: Common Questions

Can you take Blue Cohosh with Liraglutide Recombinant?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Blue Cohosh and Liraglutide Recombinant interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Liraglutide Recombinant and Blue Cohosh?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.