Drug & supplement interaction

Branched-chain Amino Acids (bcaa) + Cefaclor

Cefaclor brand names: Ceclor CD, Ceclor.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Branched-chain Amino Acids (bcaa) and Cefaclor in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Cefaclor states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Branched-chain Amino Acids (bcaa) and Cefaclor

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cefaclor and Branched-chain Amino Acids (bcaa) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Branched-chain Amino Acids (bcaa) safety at a glance

Branched-chain Ami... overall Use caution Generally well tolerated in healthy adults at typical supplement doses, but not appropriate for everyone.
Pregnancy Avoid Not enough safety data; avoid supplemental doses during pregnancy.
Breastfeeding Avoid Not enough safety data; avoid supplemental doses while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cefaclor and Branched-chain Amino Acids (bcaa)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Cefaclor

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cefaclor is filed under 6 classifications — including organic anion transporter 3 (oat3) substrates, organic anion transporter 1 (oat1) substrates, antibiotic drugs. Branched-chain Amino Acids (bcaa) has documented interactions with 2 drug classes — the most serious being levodopa (major) and antidiabetes drugs (moderate) — and none of Cefaclor’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Branched-chain Amino Acids (bcaa) Does Interact With Other Medications

Branched-chain Amino Acids (bcaa) has 5 major, 86 moderate known drug interactions in our database — Cefaclor isn’t one of them. If you take anything else, check it against the full list below.

Major 5 Moderate 86 No known interaction 2,739 (incl. Cefaclor)
Taking anything else?

Check Another of Your Medications Against Branched-chain Amino Acids (bcaa)

Covers the 2,830 medications we’ve checked against Branched-chain Amino Acids (bcaa). Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Branched-chain Amino Acids (bcaa) and Cefaclor May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Bloating or gas / Diarrhea / Vomiting / Nausea Additional detail

    Branched-chain Amino Acids (bcaa)

    “Orally, BCAAs can cause nausea, vomiting, diarrhea, and abdominal distension. Nausea and diarrhea has been reported to occur in about 10% of people taking BCAAs.”

    Branched-chain Amino Acids (bcaa) · Natural Medicines adverse-effect record, reported in diarrhea.

    4 sources cited
    1. 10117. Scarna A, Gijsman HJ, McTavish SF, et al. Effects of a branched-chain amino acid drink in mania. Br J Psychiatry 2003;182:210-3.. PubMed
    2. 37143. Long-term oral administration of branched chain amino acids after curative resection of hepatocellular carcinoma: a prospective randomized trial. The San-in Group of Liver Surgery. Br.J Surg. 1997;84(11):1525-1531. PubMed
    3. 92643. Gluud LL, Dam G, Les I, et al. Branched-chain amino acids for people with hepatic encephalopathy. Cochrane Database Syst Rev 2015;(9):CD001939. PubMed
    4. 97531. Gluud LL, Dam G, Les I, et al. Branched-chain amino acids for people with hepatic encephalopathy. Cochrane Database Syst Rev. 2017;5:CD001939. PubMed

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Tiredness Additional detail

    Branched-chain Amino Acids (bcaa)

    “Orally and intravenously, BCAAs can cause fatigue and loss of motor coordination due to increased plasma ammonia levels. Short-term use of 60 grams of BCAAs containing leucine, isoleucine, and valine for 7 days in patients with normal metabolic function seems to increase levels of ammonia, but not to toxic plasma levels. However, liver function should be monitored with high doses or long-term use.”

    Branched-chain Amino Acids (bcaa) · Natural Medicines adverse-effect record, reported in cluster headache.

    5 sources cited
    1. 693. MacLean DA, Graham TE. Branched-chain amino acid supplementation augments plasma ammonia responses during exercise in humans. J Appl Physiol 1993;74:2711-7. PubMed
    2. 694. MacLean DA, Graham TE, Saltin B. Branched-chain amino acids augment ammonia metabolism while attenuating protein breakdown during exercise. Am J Physiol 1994;267:E1010-22.
    3. 10117. Scarna A, Gijsman HJ, McTavish SF, et al. Effects of a branched-chain amino acid drink in mania. Br J Psychiatry 2003;182:210-3.. PubMed
    4. 75. Institute of Medicine. The role of protein and amino acids in sustaining and enhancing performance. Washington, DC: National Academy Press, 1999. Available at: http://books.nap.edu/books/0309063469/html/309.html#pagetop DOI
    5. 681. Tandan R, Bromberg MB, Forshew D, et al. A controlled trial of amino acid therapy in amyotrophic lateral sclerosis: I. Clinical, functional, and maximum isometric torque data. Neurology 1996;47:1220-6. PubMed

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

  • Headache Additional detail

    Branched-chain Amino Acids (bcaa)

    Recorded for Branched-chain Amino Acids (bcaa) in the same Natural Medicines adverse-effect record shown under Tiredness above.

    Cefaclor

    Listed in the ADVERSE REACTIONS section of the FDA label for Cefaclor. Read the label on DailyMed ›

Reported for Branched-chain Amino Acids (bcaa) but not commonly for Cefaclor: raised blood pressure.

Effects for Cefaclor come from the ADVERSE REACTIONS section of its FDA label; effects for Branched-chain Amino Acids (bcaa) come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Cefaclor Products Have a Food Rule — Branched-chain Amino Acids (bcaa) Should Not Break It

At least one FDA label for a product containing Cefaclor says to take it with food. If you take Branched-chain Amino Acids (bcaa) on an empty stomach out of habit, keep them separate — and take Cefaclor with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Cefaclor products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

DOSAGE AND ADMINISTRATION The absorption of cefaclor extended-release tablets is enhanced when it is administered with food.

From the Dosage and Administration section of the FDA label we read for Cefaclor — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Cefaclor

This page covers Branched-chain Amino Acids (bcaa) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cefaclor page lists 60 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), African Wild Potato (moderate) and Aristolochia (moderate).

By severity: 3 major · 46 moderate · 11 minor.

From our pharmacist’s overview on the Cefaclor page

“The entries worth understanding before any others on this cefaclor (Ceclor) page are the kidney risks and charcoal. Cefaclor is a cephalosporin antibiotic, typically a short course for ear, sinus, throat, or skin infections, and two herbs here, Siberian cocklebur and asarabacca, can damage the kidneys on their own, so pairing either wi…”

Reviewed by 2 · Jul 18, 2026

Open the Cefaclor interaction page

How much people look this up

Where Branched-chain Amino Acids (bcaa) and Cefaclor Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Branched-chain Amino Acids (bcaa)
Steady interest

#1,320 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cefaclor
Top 10%

#223 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Branched-chain Amino Acids (bcaa) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Branched-chain Amino Acids (bcaa) and Cefaclor records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Branched-chain Amino Acids (bcaa)

What is Branched-chain Amino Acids (bcaa)?

  • Muscle building and exercise recovery
  • Reducing exercise fatigue
  • Preserving muscle during weight loss
  • Liver disease support
  • Tardive dyskinesia (under study)

Branched-chain amino acids (leucine, isoleucine, and valine) are essential nutrients commonly taken by athletes for muscle support and recovery. Evidence shows modest benefits for some uses, but a balanced protein source usually provides the same amino acids. They are generally well tolerated for most healthy adults, but check with your pharmacist or doctor before use, especially if you have a medical condition.

Powder, capsules, tablets, ready-to-drink beverages

An interaction check asks whether these two react with each other — it does not ask whether Branched-chain Amino Acids (bcaa) is a good idea for someone in your situation. Here is what our Branched-chain Amino Acids (bcaa) record says about it on its own.

Branched-chain Amino Acids (bcaa): dosing

There is no single official dose for BCAA supplements, and the amount used in studies has varied widely. Products differ in how much leucine, isoleucine, and valine they contain, and in the ratio between them.The best approach is to follow the directions on the product label and not take more than recommended.

From our Branched-chain Amino Acids (bcaa) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Branched-chain Amino Acids (bcaa) monograph & all interactions
Medication

About Cefaclor

What Is Cefaclor Used For?

Brand names: Ceclor CD, Ceclor

Cefaclor treats a range of bacterial infections. Cefaclor capsules and oral suspension are used for ear infections (otitis media), lower respiratory tract infections including pneumonia, strep throat and tonsillitis, urinary tract infections (including kidney infections and bladder infections), and skin and skin structure infections.

Cefaclor extended-release tablets are approved for a narrower set of uses in adults: acute bacterial flare-ups of chronic bronchitis, strep throat and tonsillitis, and uncomplicated skin and skin structure infections. Not all formulations are approved for the same conditions, so the form matters.

See full Cefaclor drug information
Keep checking

Other Drugs & Branched-chain Amino Acids (bcaa)

Browse every other medication we’ve checked against Branched-chain Amino Acids (bcaa) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

5Major
86Moderate
0Minor
2,738No known interaction
5 Major 86 Moderate 2,738 No interaction
Major

5 interactions

Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Branched-chain Amino Acids (bcaa) page.

No interaction 2,738 drugs checked — show the list

We also checked Branched-chain Amino Acids (bcaa) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,738 medications checked with no known interaction — see the full Branched-chain Amino Acids (bcaa) list.

See the full Branched-chain Amino Acids (bcaa) interactions page
See every supplement checked against Cefaclor, ranked by severity
Evidence & sources

Branched-chain Amino Acids (bcaa) References

The 20 references that drive our Branched-chain Amino Acids (bcaa) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Rosen HM, Yoshimura N, Hodgman JM, Fischer JE. Plasma amino acid patterns in hepatic encephalopathy of differing etiology. Gastroenterology 1977;72:483-7. DOI
  2. Institute of Medicine. The role of protein and amino acids in sustaining and enhancing performance. Washington, DC: National Academy Press, 1999. Available at: http://books.nap.edu/books/0309063469/html/309.html#pagetop DOI
  3. Tandan R, Bromberg MB, Forshew D, et al. A controlled trial of amino acid therapy in amyotrophic lateral sclerosis: I. Clinical, functional, and maximum isometric torque data. Neurology 1996;47:1220-6. PubMed
  4. MacLean DA, Graham TE. Branched-chain amino acid supplementation augments plasma ammonia responses during exercise in humans. J Appl Physiol 1993;74:2711-7. PubMed
  5. MacLean DA, Graham TE, Saltin B. Branched-chain amino acids augment ammonia metabolism while attenuating protein breakdown during exercise. Am J Physiol 1994;267:E1010-22.
  6. DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
  7. Nutt JG, Woodward WR, Hammerstad JP, et al. The "on-off" phenomenon in Parkinson's disease. Relation to levodopa absorption and transport. N Engl J Med 1984;310:483-8. PubMed
  8. Baruzzi A, Contin M, Riva R, et al. Influence of meal ingestion time on pharmacokinetics of orally administered levodopa in parkinsonian patients. Clin Neuropharmacol 1987;10:527-37. PubMed
  9. Juncos JL, Fabbrini G, Mouradian MM, et al. Dietary influences on the antiparkinsonian response to levodopa. Arch Neurol 1987;44:1003-5. PubMed
  10. Eriksson T, Granerus AK, Linde A, et al. "On-off" phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma. Neurology 1988;38:1245-8. PubMed
  11. Hutson SM, Harris RA. Introduction. Symposium: Leucine as a nutritional signal. J Nutr 2001;131:839S-40S.
  12. Kimball SR, Jefferson LS. Control of protein synthesis by amino acid availability. Curr Opin Clin Nutr Metab Care 2002;5:63-7.. PubMed
  13. Anthony JC, Lang CH, Crozier SJ, et al. Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine. Am J Physiol Endocrinol Metab 282:E1092-101.. PubMed
  14. Kimball SR, Farrell PA, Jefferson LS. Invited review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or excercise. J Appl Physiol 2002;93:1168-80..
  15. Scarna A, Gijsman HJ, McTavish SF, et al. Effects of a branched-chain amino acid drink in mania. Br J Psychiatry 2003;182:210-3.. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Branched-chain Amino Acids (bcaa) and Cefaclor Together: Common Questions

Is it safe to take Branched-chain Amino Acids (bcaa) with Cefaclor?
We do not list a known interaction between Branched-chain Amino Acids (bcaa) and Cefaclor. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Branched-chain Amino Acids (bcaa) and Cefaclor have any of the same side effects?
Yes — our sources link each of them separately to 6 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Branched-chain Amino Acids (bcaa) and Cefaclor at the same time of day?
At least one FDA label for a product containing Cefaclor says to take it with food. If you take Branched-chain Amino Acids (bcaa) on an empty stomach out of habit, keep them separate and take Cefaclor with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Cefaclor products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Branched-chain Amino Acids (bcaa) and Cefaclor combination checked?
Interactions in our licensed database are recorded against drug classes. Cefaclor is filed under 6 classifications, and Branched-chain Amino Acids (bcaa) has documented interactions with 2 drug classes — none of Cefaclor's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Branched-chain Amino Acids (bcaa) interact with any other medications?
Yes. Branched-chain Amino Acids (bcaa) has 91 documented drug interactions in our database — Cefaclor is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Cefaclor interact with any supplements?
Yes. Cefaclor has documented interactions with 60 supplements in our database — Branched-chain Amino Acids (bcaa) is not one of them. The Cefaclor interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Branched-chain Amino Acids (bcaa) monograph Uses, safety profile, and every drug interaction in one place Cefaclor drug information The full plain-English guide to this medication Cefaclor supplement interactions Every supplement checked against Cefaclor, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 20 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cefaclor and Branched-chain Amino Acids (bcaa)?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.