Drug & supplement interaction

Buchu + Liotrix

Liotrix brand names: Euthroid 3, Euthroid 1/2, Euthroid 1.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Buchu and Liotrix in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Liotrix states a food rule worth keeping to.

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Interaction report

Buchu and Liotrix

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Liotrix and Buchu in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Buchu safety at a glance

Buchu overall Use caution Generally used in food amounts, but medicinal doses lack strong safety data and the essential oil may be irritating.

Pregnancy Likely Unsafe When used in medicinal amounts; buchu is reported to be an abortifacient. Read the full pregnancy detail

Breastfeeding Possibly Safe When used in food amounts. There is insufficient reliable information available about the safety of using larger amounts; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Liotrix and Buchu? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Liotrix

Interactions in our licensed database are recorded against drug classes, not just single drug names. Liotrix is filed under 2 classifications — thyroid hormone, oral drugs. Buchu has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), hepatotoxic drugs (moderate) and lithium (moderate) — and none of Liotrix’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Buchu Does Interact With Other Medications

Buchu has 481 moderate known drug interactions in our database — Liotrix isn’t one of them. If you take anything else, check it against the full list below.

Moderate 481 No known interaction 2,349 (incl. Liotrix)

Taking anything else?

Check Another of Your Medications Against Buchu

Covers the 2,830 medications we’ve checked against Buchu. Pick one to open its full report.

What to actually watch for

What Liotrix’s Own FDA Label Lists

This is not an interaction — none of it involves Buchu. These are the most notable effects listed in the ADVERSE REACTIONS section of Liotrix’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

A change in thyroid levels Worth acting on
Bone thinning Worth acting on
Muscle weakness Worth acting on
A heart attack Worth acting on
Heart failure Worth acting on
Wheezing Worth acting on
Seizures Worth acting on
Chest pain Worth acting on
Shortness of breath Worth acting on
A severe allergic reaction Worth acting on

Showing the 10 most notable of 32 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Liotrix. Read the label on DailyMed › Buchu’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Buchu side to compare — that is a limit of the record, not a statement that Buchu has no side effects.

Special populations

Buchu in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used in medicinal amounts; buchu is reported to be an abortifacient.

Lactation Possibly Safe

When used in food amounts. There is insufficient reliable information available about the safety of using larger amounts; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Liotrix Products Have a Food Rule — Buchu Should Not Break It

At least one FDA label for a product containing Liotrix says to take it on an empty stomach. Most supplements — Buchu included — are taken with a meal, so the easy mistake is swallowing both together at breakfast. Where that rule applies, keep Liotrix on its own and move Buchu to a meal later in the day.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Liotrix products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Liotrix

This page covers Buchu only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Liotrix page lists 38 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Tiratricol (major), Acetyl-l-carnitine (moderate), Alpha-lipoic Acid (moderate) and Ascophyllum Nodosum (moderate).

By severity: 2 major · 26 moderate · 10 minor.

From our pharmacist’s overview on the Liotrix page

“Liotrix (Euthroid) combines both thyroid hormones, and since steady hormone levels are the entire point of treatment, this list deserves a slow, serious read. Most entries fall into two camps: twenty-one ingredients act on the hormone itself, some boosting it and others blunting it, while another seventeen change how well the dose is a…”

Reviewed by 2 · Jul 18, 2026

Open the Liotrix interaction page

One more smart check

Taking Buchu as Part of a Dietary Supplement Product? Check It for Interactions

We hold 128 real supplement products containing Buchu, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Buchu. Even though Buchu itself has no known interaction with Liotrix, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Buchu and Liotrix Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Buchu

Top 25%

#254 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Liotrix

Steady interest

#2,311 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Buchu reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Buchu and Liotrix records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Buchu

What is Buchu?

Urinary tract complaints
Diuretic (increasing urine flow)
Bloating and fluid retention
Mild digestive upset
Antimicrobial/antiseptic use
Flavoring and fragrance

Buchu is a fragrant South African shrub whose leaves are traditionally used for urinary and bladder complaints and as a diuretic. Solid human studies are lacking, so its benefits are largely unproven, and it should be avoided in pregnancy and breastfeeding. Talk to a pharmacist or doctor before using it, especially if you have kidney or liver problems.

Agathosma betulina · Rutaceae · Leaves and essential oil · Tea, capsules, tincture, dried leaf, essential oil

An interaction check asks whether these two react with each other — it does not ask whether Buchu is a good idea for someone in your situation. Here is what our Buchu record says about it on its own.

Buchu: dosing

There is no well-established standardized dose for buchu. Traditional preparations include teas made from the dried leaf and tinctures, but reliable human studies have not confirmed a safe and effective amount.If you choose to use a buchu product, follow the directions on the label and do not exceed them. Avoid taking the concentrated essential oil internally.

From our Buchu monograph — the full record covers uses, side effects and every documented interaction.

Read the full Buchu monograph & all interactions

Medication

About Liotrix

What Is Liotrix Used For?

Brand names: Euthroid 3, Euthroid 1/2, Euthroid 1

Liotrix is used to treat hypothyroidism (a condition that results when the thyroid gland does not produce enough thyroid hormone). Symptoms of hypothyroidism include lack of energy, depression, constipation, weight gain, hair loss, dry skin, dry coarse hair, muscle cramps, decreased concentration, aches and pains, swelling of the legs, and increased sensitivity to cold. When taken correctly, liotrix can reverse these symptoms. Liotrix is also used to treat goiter (enlarged thyroid gland). This medication is also used to test for hyperthyroidism (a condition where the thyroid gland produces too much thyroid hormone). Liotrix is in a class of medications called thyroid agents. It works by supplying the thyroid hormones normally produced by the body.

See full Liotrix drug information

Keep checking

Other Drugs & Buchu

Browse every other medication we’ve checked against Buchu — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

481Moderate

0Minor

2,348No known interaction

481 Moderate 2,348 No interaction

Moderate

481 interactions

Showing 60 of 481 moderate interactions — see all 481 on the Buchu page.

No interaction 2,348 drugs checked — show the list

We also checked Buchu against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,348 medications checked with no known interaction — see the full Buchu list.

See the full Buchu interactions page

See every supplement checked against Liotrix, ranked by severity

Evidence & sources

Buchu References

The 3 references that drive our Buchu monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
Moolla A, Viljoen AM. 'Buchu' - Agathosma betulina and Agathosma crenulata (Retaceae): a review. J Ethnopharmacol 2008;119(3):413-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Buchu and Liotrix Together: Common Questions

Is it safe to take Buchu with Liotrix?

We do not list a known interaction between Buchu and Liotrix. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Should I take Buchu and Liotrix at the same time of day?

At least one FDA label for a product containing Liotrix says to take it on an empty stomach, and supplements are usually taken with a meal — so taking them together at breakfast is the easy mistake. Where that applies, keep Liotrix on its own and move Buchu to a meal later in the day. Food instructions belong to the product rather than the ingredient, so check the directions on your own box. This is about absorption, not an interaction.

How was the Buchu and Liotrix combination checked?

Interactions in our licensed database are recorded against drug classes. Liotrix is filed under 2 classifications, and Buchu has documented interactions with 3 drug classes — none of Liotrix's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Buchu interact with any other medications?

Yes. Buchu has 481 documented drug interactions in our database — Liotrix is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Liotrix interact with any supplements?

Yes. Liotrix has documented interactions with 38 supplements in our database — Buchu is not one of them. The Liotrix interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Buchu monograph Uses, safety profile, and every drug interaction in one place Liotrix drug information The full plain-English guide to this medication Liotrix supplement interactions Every supplement checked against Liotrix, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Liotrix and Buchu?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.