Drug & supplement interaction

Calamint + Eplerenone

Eplerenone brand name: Inspra.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Calamint and Eplerenone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Calamint and Eplerenone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Eplerenone and Calamint in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Calamint at all — not against Eplerenone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Calamint safety at a glance

Calamint overall Use caution Generally considered safe in small culinary or tea amounts, but human safety data are limited, especially for the essential oil.
Pregnancy Avoid Avoid medicinal or concentrated amounts during pregnancy because safety has not been established.
Breastfeeding Avoid Not enough safety information is available, so it is best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Eplerenone and Calamint? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Eplerenone’s Own FDA Label Lists

This is not an interaction — none of it involves Calamint. These are the most notable effects listed in the ADVERSE REACTIONS section of Eplerenone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 8 of them are worth acting on rather than waiting out — marked below.

  • Heart failure Worth acting on mentioned in 7.6% of FDA reports for Eplerenone
  • High potassium Worth acting on
  • Low potassium Worth acting on
  • A heart attack Worth acting on
  • Kidney problems Worth acting on mentioned in 7.4% of FDA reports for Eplerenone
  • Chest pain Worth acting on
  • Raised blood pressure Worth acting on
  • Bleeding or bruising Worth acting on
  • Breast tenderness
  • Dizziness mentioned in 5.3% of FDA reports for Eplerenone

Showing the 10 most notable of 13 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Eplerenone. Read the label on DailyMed › Where a percentage is shown, it is the share of 12,732 voluntary FDA FAERS reports for Eplerenone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Calamint’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Calamint side to compare — that is a limit of the record, not a statement that Calamint has no side effects.

From our Q&A

Questions About Calamint or Eplerenone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Calamint or Eplerenone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Eplerenone

This page covers Calamint only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Eplerenone page lists 136 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Tyramine (major) and Adrafinil (moderate).

By severity: 4 major · 111 moderate · 21 minor.

Open the Eplerenone interaction page

How much people look this up

Where Calamint and Eplerenone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Calamint
Steady interest

#972 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Eplerenone
Top 25%

#561 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Calamint is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Calamint reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Calamint and Eplerenone records this page draws on were last updated June 20, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Calamint

What is Calamint?

  • Digestive upset and gas
  • Coughs and respiratory complaints
  • Mild anxiety or as a calming tea
  • Culinary flavoring
  • Topical or aromatic uses

Calamint is an aromatic, mint-family herb used traditionally as a tea for digestion, coughs, and general wellness, but there is very little human research to confirm any health benefits. It is most often used in small culinary amounts; concentrated forms and the essential oil should be used cautiously, and it is best avoided during pregnancy and breastfeeding due to a lack of safety data.

Calamintha nepeta · Lamiaceae · Leaves, flowering tops, and essential oil · Tea (infusion), dried herb, essential oil, occasionally tinctures

An interaction check asks whether these two react with each other — it does not ask whether Calamint is a good idea for someone in your situation. Here is what our Calamint record says about it on its own.

Calamint: dosing

There is no established or standardized medicinal dose for calamint, because it has not been well studied in people. Traditionally it is used as a mild tea made from a small amount of the dried leaves or flowering tops steeped in hot water.If you choose to use a calamint product, follow the directions on the label and do not exceed the suggested amount. The essential oil is very concentrated and should not be swallowed unless directed by a qualified professional.

From our Calamint monograph — the full record covers uses, side effects and every documented interaction.

Read the full Calamint monograph & all interactions
Medication

About Eplerenone

What Is Eplerenone Used For?

Brand name: Inspra

Eplerenone treats two conditions. First, it is used to lower high blood pressure (hypertension) in adults. Lowering blood pressure reduces the risk of stroke and heart attack. It can be used alone or alongside other blood pressure medicines.

Second, eplerenone is used to improve survival in stable adults who have heart failure with reduced ejection fraction (HFrEF) — meaning the heart pumps less blood than normal — following an acute myocardial infarction (heart attack).

Most-Reported Side Effects for Eplerenone

From FAERS, the FDA’s public side-effect reporting system (12,732 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Dyspnea 1,138 reports
Cardiac failure 966 reports
Acute kidney injury 946 reports
Hypotension 888 reports
Fatigue 690 reports
See full Eplerenone drug information
Keep checking

Other Drugs & Calamint

Browse every other medication we’ve checked against Calamint — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Calamint against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Calamint list.

See the full Calamint interactions page
See every supplement checked against Eplerenone, ranked by severity
Evidence & sources

Calamint References

The 1 sources that drive our Calamint monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Calamint is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Calamint and Eplerenone Together: Common Questions

Is it safe to take Calamint with Eplerenone?
We do not list a known interaction between Calamint and Eplerenone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Does Eplerenone interact with any supplements?
Yes. Eplerenone has documented interactions with 136 supplements in our database — Calamint is not one of them. The Eplerenone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Calamint monograph Uses, safety profile, and every drug interaction in one place Eplerenone drug information The full plain-English guide to this medication Eplerenone supplement interactions Every supplement checked against Eplerenone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Eplerenone and Calamint?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.