Medication interaction hub

What Supplements Interact with Eplerenone?

Eplerenone brand name: Inspra. Every interaction below applies to the brands too.

136 Interactions 4 Major 111 Moderate 21 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Eplerenone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Eplerenone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line

136 supplements and herbal ingredients have interactions with Eplerenone on file in the HelloPharmacist interaction database — 4 rated major, 111 moderate, and 21 minor. The most serious involve American Hellebore, Tyramine, Activated Charcoal and American Mistletoe.

Our assessment: with 4 major-rated interactions on the list, this one deserves real attention — know the major entries before combining anything with Eplerenone.

Major 4 Moderate 111 Minor 21 No known interaction 1,316

Ranked by severity below. Every entry links to the full pharmacist-reviewed report for that exact combination — what can happen, how likely it is, and what to do about it.

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Eplerenone: Top Interactions at a Glance

The most significant Eplerenone supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 136 interacting ingredients — plus 1,316 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Eplerenone + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely American Hellebore + Eplerenonei

American hellebore can have potent cardiovascular effects due to the toxic steroid ester alkaloids it contains.

Read the full interaction Major Likelihood Likely Tyramine + Eplerenonei

Tyramine may increase the risk of hypertension and reduce the effects of antihypertensive drugs.

Read the full interaction Major Likelihood Probable Activated Charcoal + Eplerenonei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable American Mistletoe + Eplerenonei

American mistletoe contains phoratoxin, a compound toxic to humans that induces smooth muscle contraction and vasoconstriction, potentially increasing blood pre...

Read the full interaction
The complete list

Every Supplement Checked Against Eplerenone

All 1,452 ingredients in our database, ranked by severity — 136 with a Eplerenone interaction on file and 1,316 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Eplerenone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Tribulus with Eplerenone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.

Full Tribulus + Eplerenone answer

Can you take Vitamin B6 with Eplerenone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.

Full Vitamin B6 + Eplerenone answer

Can you take White Horehound with Eplerenone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that taking white horehound extract lowers blood pressure.

Full White Horehound + Eplerenone answer

Can you take Thyroid Extract with Eplerenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Eplerenone answer

Can you take Agar with Eplerenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Agar forms a thick gel, which may disrupt the absorption of nutrients and medications.

Full Agar + Eplerenone answer

Can you take Algin with Eplerenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, algin can alter the absorption of oral drugs.

Full Algin + Eplerenone answer

Can you take Beet with Eplerenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure.

Full Beet + Eplerenone answer

Can you take Black Psyllium with Eplerenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Black Psyllium + Eplerenone answer

Can you take Blond Psyllium with Eplerenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.

Full Blond Psyllium + Eplerenone answer

Can you take Carob with Eplerenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, carob might also impair the absorption of oral drugs.

Full Carob + Eplerenone answer

Can you take Coenzyme Q10 with Eplerenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.

Full Coenzyme Q10 + Eplerenone answer

Can you take Dendrobium with Eplerenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. The dendrobium constituent dendrobine is reported to have hypotensive effects.

Full Dendrobium + Eplerenone answer

Can you take Fenugreek with Eplerenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Fenugreek may also have an additive effect on blood pressure-lowering medications.

Full Fenugreek + Eplerenone answer

Can you take Green Coffee with Eplerenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking green coffee with antihypertensive drugs might increase the risk of hypotension.

Full Green Coffee + Eplerenone answer

Can you take Humann Superbeets Heart Chews with Eplerenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Each serving of HumanN SuperBeets includes 500mg of beetroot powder (2 chews).

Full Humann Superbeets Heart Chews + Eplerenone answer

Can you take Karaya Gum with Eplerenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Co-administration of oral drugs with bulk forming laxatives such as karaya gum may decrease, increase, or have no effect on the absorption o...

Full Karaya Gum + Eplerenone answer

Can you take Marshmallow with Eplerenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, mucilage in marshmallow might impair absorption of oral drugs.

Full Marshmallow + Eplerenone answer

Can you take N-methyltyramine with Eplerenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. In animal research, N-methyltyramine increased blood pressure.

Full N-methyltyramine + Eplerenone answer

Can you take Nicotinamide Riboside with Eplerenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.

Full Nicotinamide Riboside + Eplerenone answer

Can you take Puravive with Eplerenone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Puravive contains quercetin, which has been found to slightly reduce blood pressure in individuals with mild hypertension (https://pubmed.nc...

Full Puravive + Eplerenone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Eplerenone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Eplerenone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Eplerenone sits in 2 interaction categories. Open any one to see what the group means:

Antihypertensive Drugs 119 ingredients

Blood-pressure-lowering medications. Supplements that lower (or raise) blood pressure can amplify or fight these drugs.

119 of the supplement ingredients on this page reach Eplerenone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Eplerenone through this category.

About Eplerenone

Eplerenone is a mineralocorticoid receptor antagonist used to treat high blood pressure, often combined with other medications.

Generic name: Eplerenone  ·  Brand name: Inspra.

See the full Eplerenone drug information

Related: does Eplerenone deplete any nutrients?

Eplerenone has 1 reported nutrient association in the research literature — see the Eplerenone nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Eplerenone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Eplerenone.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Products that contain Eplerenone-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Eplerenone.

TNT Thermanite by GEC Genetic Edge Compounds contains Tyramine Diablos ECA Fire Caps by Innovative Laboratories contains Tyramine Ultimate Burn by Schwartz Laboratories contains Tyramine Final Cutz by Infinite Labs contains Tyramine
Pharmacist Counseling Corner

Eplerenone & Supplements: Common Questions

What supplements interact with Eplerenone?
In our interaction database, 136 supplement and herbal ingredients have an interaction with Eplerenone on file — 4 rated major, 111 moderate, and 21 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: American Hellebore, Tyramine, Activated Charcoal.
Which Eplerenone supplement interactions are the most serious?
Focus on the major group: American Hellebore, Tyramine, Activated Charcoal and American Mistletoe. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Eplerenone?
That depends entirely on which supplement. The honest answer for Eplerenone is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Inspra have the same supplement interactions as Eplerenone?
Yes — Inspra all contain Eplerenone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Eplerenone deplete any vitamins or nutrients?
It might — Eplerenone has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Eplerenone nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Eplerenone and my other medications?
This page covers Eplerenone against supplements and herbal ingredients. Checking Eplerenone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Eplerenone drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.