Drug & supplement interaction

Celery + Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital

Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital brand name: Cafergot PB.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Celery has a moderate interaction with Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital. Theoretically, celery might increase levels of drugs metabolized by CYP1A2.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Celery and Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES

Why this applies to Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital

Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital falls under CYTOCHROME P450 1A2 (CYP1A2) SUBSTRATES — the group Celery interacts with.

Theoretically, celery might increase levels of drugs metabolized by CYP1A2.
In vitro and animal research suggests that constituents of celery can inhibit CYP1A2. This effect has not been reported in humans.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combination pill (Cafergot PB) is a mix of ingredients used for migraines. The piece that matters here is the caffeine, which your body clears mainly through an enzyme called CYP1A2. In lab dishes and animal studies, compounds in celery seem to slow that enzyme down. If the same thing happened in people, caffeine could hang around longer and build up, which might mean more jitteriness, a racing heart, trouble sleeping, or feeling wired.

Here's the reassuring part: this is only a theoretical concern based on test-tube and animal work, and it has never actually been shown in humans. Eating celery as food is very unlikely to cause any trouble. Concentrated celery seed extracts or oils are where I'd be a bit more cautious. If you take those regularly, just mention it to your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Peterson, S., Lampe, J. W., Bammler, T. K., Gross-Steinmeyer, K., and Eaton, D. L. Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1. Food Chem.Toxicol. 2006;44(9):147 PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Celery Also Interacts With Other Medications

Celery has 448 moderate, 202 minor known drug interactions in our database — the Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital one above is one of them. If you take anything else, check it against the full list below.

Moderate 448 Minor 202 No known interaction 2,180 (incl. Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital)
Taking anything else?

Check Another of Your Medications Against Celery

Covers the 2,830 medications we’ve checked against Celery. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital

This page covers Celery only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital page lists 269 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Ephedra (major) and Gamma-hydroxybutyrate (ghb) (major).

By severity: 13 major · 210 moderate · 46 minor.

From our pharmacist’s overview on the Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital page

“Cafergot PB combines ergotamine, caffeine, pentobarbital, and belladonna alkaloids to treat migraine, and the person taking it is often the same person reaching for kava to sleep or an herbal energy product afterward, which is exactly where the trouble sits. This list warrants genuine care.”

Reviewed by 2 · Jul 18, 2026

Open the Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interaction page

One more smart check

Taking Celery as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,687 real supplement products containing Celery, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Celery. Your product may carry other ingredients that interact with Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital too, on top of Celery — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Celery and Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Celery
Top 25%

#154 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital
Steady interest

#1,804 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Celery

What is Celery?

Celery
  • High blood pressure
  • Fluid retention (diuretic)
  • Joint pain and inflammation
  • Anxiety and sleep
  • Digestive support

Celery is a common vegetable that is also taken as a seed extract or oil supplement, mainly for blood pressure, fluid retention, and joint discomfort. Human evidence for these supplement uses is limited and mostly preliminary, so it should not replace proven treatments. Celery is generally safe as food, but concentrated supplements and possible allergic reactions warrant caution.

Read the full Celery monograph & all interactions
Keep checking

Other Drugs & Celery

Browse every other medication we’ve checked against Celery — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
448Moderate
202Minor
2,179No known interaction
448 Moderate 202 Minor 2,179 No interaction
Moderate

448 interactions

Showing 60 of 448 moderate interactions — see all 448 on the Celery page.

Minor

202 interactions

Showing 60 of 202 minor interactions — see all 202 on the Celery page.

No interaction 2,179 drugs checked — show the list

We also checked Celery against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,179 medications checked with no known interaction — see the full Celery list.

See the full Celery interactions page
See every supplement checked against Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Celery monograph › Uses, safety, and every drug interaction in one place Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital supplement interactions › Every supplement checked against Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Celery and Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital Together: Common Questions

Can you take Celery with Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Celery and Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Bellafoline, Caffeine, Ergotamine Tartrate, Pentobarbital and Celery?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.