Drug & supplement interaction

Chenopodium Oil + Zoledronic Acid

Zoledronic Acid brand names: Zometa, Aclasta, Reclast.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Chenopodium Oil and Zoledronic Acid in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Chenopodium Oil and Zoledronic Acid

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Zoledronic Acid and Chenopodium Oil in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chenopodium Oil safety at a glance

Chenopodium Oil overall Avoid The oil contains ascaridole, which is toxic and has a narrow margin between an effective and a dangerous dose.
Pregnancy Avoid It may stimulate the uterus and is potentially toxic, so it should not be used during pregnancy.
Breastfeeding Unsafe When used orally due to toxicity. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Zoledronic Acid and Chenopodium Oil? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Zoledronic Acid

Interactions in our licensed database are recorded against drug classes, not just single drug names. Zoledronic Acid is filed under a single classification — bisphosphonates. Chenopodium Oil has documented interactions with 1 drug class — the most serious being photosensitizing drugs (moderate) — and none of Zoledronic Acid’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Chenopodium Oil Does Interact With Other Medications

Chenopodium Oil has 335 moderate known drug interactions in our database — Zoledronic Acid isn’t one of them. If you take anything else, check it against the full list below.

Moderate 335 No known interaction 2,495 (incl. Zoledronic Acid)
Taking anything else?

Check Another of Your Medications Against Chenopodium Oil

Covers the 2,830 medications we’ve checked against Chenopodium Oil. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Chenopodium Oil and Zoledronic Acid May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Dizziness / Headache Additional detail

    Chenopodium Oil

    “Orally, chenopodium oil affects the nervous system and can cause headache, vertigo/dizziness, temporary deafness, convulsions, circulatory collapse, paralysis, and death (11).”

    Chenopodium Oil · Natural Medicines adverse-effect record, reported in cluster headache.

    1 source cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

    Zoledronic Acid

    Listed in the ADVERSE REACTIONS section of the FDA label for Zoledronic Acid. Read the label on DailyMed ›

  • Vomiting Additional detail

    Chenopodium Oil

    “Orally, chenopodium oil can cause vomiting (11).”

    Chenopodium Oil · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

    Zoledronic Acid

    Listed in the ADVERSE REACTIONS section of the FDA label for Zoledronic Acid. Read the label on DailyMed ›

Reported for Chenopodium Oil but not commonly for Zoledronic Acid: liver problems, seizures and hearing loss.

Effects for Zoledronic Acid come from the ADVERSE REACTIONS section of its FDA label; effects for Chenopodium Oil come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Chenopodium Oil in Pregnancy & Breastfeeding

Lactation Unsafe

When used orally due to toxicity.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Zoledronic Acid

This page covers Chenopodium Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Zoledronic Acid page lists 6 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Calcium (moderate), Dolomite (moderate), Iron (moderate), Magnesium (moderate) and Phosphate Salts (moderate).

By severity: 6 moderate.

From our pharmacist’s overview on the Zoledronic Acid page

“Most people on zoledronic acid (Reclast, Zometa) take it to protect their bones, and many are also told to take calcium, which happens to be the headline item on this short interaction list. All six ingredients on file rate moderate, none major, so these combinations are workable for most people once you realize that timing is nearly t…”

Reviewed by 2 · Jul 18, 2026

Open the Zoledronic Acid interaction page

One more smart check

Taking Chenopodium Oil as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Chenopodium Oil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chenopodium Oil. Even though Chenopodium Oil itself has no known interaction with Zoledronic Acid, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chenopodium Oil and Zoledronic Acid Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chenopodium Oil
Steady interest

#1,362 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Zoledronic Acid
Steady interest

#2,138 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chenopodium Oil reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Chenopodium Oil and Zoledronic Acid records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chenopodium Oil

What is Chenopodium Oil?

Chenopodium Oil
  • Intestinal worms (roundworm, hookworm)
  • Digestive upset and gas
  • Respiratory complaints
  • Skin conditions
  • As a culinary seasoning (epazote leaf)

Chenopodium oil is a strong-smelling essential oil from the epazote plant that was historically used to treat intestinal worms. It contains ascaridole, a compound that is quite toxic, and overdoses have caused serious harm, so it is no longer recommended for internal use. Safer modern deworming medicines exist, so talk with a pharmacist or doctor before using this oil.

Dysphania ambrosioides · Amaranthaceae · Essential oil from the leaves and seeds · Essential oil; sometimes the leaf is used as a tea or culinary herb (epazote)

An interaction check asks whether these two react with each other — it does not ask whether Chenopodium Oil is a good idea for someone in your situation. Here is what our Chenopodium Oil record says about it on its own.

Chenopodium Oil: dosing

There is no safe, established dose of chenopodium oil for any condition, and it is not recommended for self-treatment. For intestinal worms, safer and more effective prescription and over-the-counter medicines are available.

From our Chenopodium Oil monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chenopodium Oil monograph & all interactions
Medication

About Zoledronic Acid Injection

What Is Zoledronic Acid Injection Used For?

Brand names: Zometa, Aclasta, Reclast

Zoledronic acid injection is used to treat and prevent osteoporosis in postmenopausal women, increase bone mass in men with osteoporosis, and treat or prevent osteoporosis caused by long-term steroid (glucocorticoid) use in men and women. It is also used to treat Paget's disease of bone in men and women.

In postmenopausal women with osteoporosis, it reduces the risk of hip, spine, and other fractures. For patients at low fracture risk, your doctor may consider stopping therapy after 3 to 5 years — the right duration is a conversation to have with your prescriber.

Most-Reported Side Effects for Zoledronic Acid

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Arthralgia 3,222 reports
Nausea 2,818 reports
Fever 2,811 reports
Fatigue 2,798 reports
Osteonecrosis of jaw 2,709 reports
See full Zoledronic Acid Injection drug information
Keep checking

Other Drugs & Chenopodium Oil

Browse every other medication we’ve checked against Chenopodium Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
335Moderate
0Minor
2,494No known interaction
335 Moderate 2,494 No interaction
Moderate

335 interactions

Showing 60 of 335 moderate interactions — see all 335 on the Chenopodium Oil page.

No interaction 2,494 drugs checked — show the list

We also checked Chenopodium Oil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,494 medications checked with no known interaction — see the full Chenopodium Oil list.

See the full Chenopodium Oil interactions page
See every supplement checked against Zoledronic Acid, ranked by severity
Evidence & sources

Chenopodium Oil References

The 2 references that drive our Chenopodium Oil monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chenopodium Oil and Zoledronic Acid Together: Common Questions

Is it safe to take Chenopodium Oil with Zoledronic Acid?
We do not list a known interaction between Chenopodium Oil and Zoledronic Acid. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Chenopodium Oil and Zoledronic Acid have any of the same side effects?
Yes — our sources link each of them separately to 3 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Chenopodium Oil and Zoledronic Acid combination checked?
Interactions in our licensed database are recorded against drug classes. Zoledronic Acid is filed under 1 classification, and Chenopodium Oil has documented interactions with 1 drug class — none of Zoledronic Acid's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Chenopodium Oil interact with any other medications?
Yes. Chenopodium Oil has 335 documented drug interactions in our database — Zoledronic Acid is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Zoledronic Acid interact with any supplements?
Yes. Zoledronic Acid has documented interactions with 6 supplements in our database — Chenopodium Oil is not one of them. The Zoledronic Acid interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chenopodium Oil monograph Uses, safety profile, and every drug interaction in one place Zoledronic Acid Injection drug information The full plain-English guide to this medication Zoledronic Acid supplement interactions Every supplement checked against Zoledronic Acid, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Zoledronic Acid and Chenopodium Oil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.