Drug & supplement interaction

Magnesium + Zoledronic Acid

Zoledronic Acid brand names: Zometa, Aclasta, Reclast.

Moderate Interaction
Medically reviewed by · Updated October 2026
The bottom line Moderate

Magnesium has a moderate interaction with Zoledronic Acid. Magnesium can decrease absorption of bisphosphonates.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Magnesium and Zoledronic Acid

Here is the interaction we found between these two, with the evidence behind it.

Moderate

BISPHOSPHONATES

Why this applies to Zoledronic Acid

Zoledronic Acid falls under BISPHOSPHONATES — the group Magnesium interacts with.

Magnesium can decrease absorption of bisphosphonates.
Cations, including magnesium, can decrease bisphosphonate absorption. Advise patients to separate doses of magnesium and these drugs by at least 2 hours.
Severity Moderate Likelihood Probable Evidence B

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's some good news if you take zoledronic acid as your once-yearly or occasional infusion (Reclast or Zometa): this is given through a vein at the clinic, not swallowed as a pill. The interaction on file is about oral bisphosphonates, where minerals like magnesium can grab onto the drug in your stomach and keep it from being absorbed. With an IV infusion, that absorption step is skipped entirely, so your magnesium supplement won't blunt the bone-protecting effect.

That said, magnesium levels can shift around zoledronic acid since it lowers calcium and related minerals. I'd still mention your magnesium supplement to your doctor or pharmacist, especially if you have kidney issues, so they can keep an eye on your bloodwork.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Dunn CJ, Goa KL. Risedronate: a review of its pharmacological properties and clinical use in resorptive bone disease. Drugs 2001;61:685-712..

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Magnesium Also Interacts With Other Medications

Magnesium has 6 major, 174 moderate, 114 minor known drug interactions in our database — the Zoledronic Acid one above is one of them. If you take anything else, check it against the full list below.

Major 6 Moderate 174 Minor 114 No known interaction 2,536 (incl. Zoledronic Acid)
Taking anything else?

Check Another of Your Medications Against Magnesium

Covers the 2,830 medications we’ve checked against Magnesium. Pick one to open its full report.

From our Q&A

Questions About Magnesium or Zoledronic Acid

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Magnesium or Zoledronic Acid, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Zoledronic Acid

This page covers Magnesium only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Zoledronic Acid page lists 6 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Calcium (moderate), Dolomite (moderate), Iron (moderate), Phosphate Salts (moderate) and Whey Protein (moderate).

By severity: 6 moderate.

From our pharmacist’s overview on the Zoledronic Acid page

“Most people on zoledronic acid (Reclast, Zometa) take it to protect their bones, and many are also told to take calcium, which happens to be the headline item on this short interaction list. All six ingredients on file rate moderate, none major, so these combinations are workable for most people once you realize that timing is nearly t…”

Reviewed by 2 · Jul 18, 2026

Open the Zoledronic Acid interaction page

One more smart check

Taking Magnesium as Part of a Dietary Supplement Product? Check It for Interactions

We hold 29,718 real supplement products containing Magnesium, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Magnesium. Your product may carry other ingredients that interact with Zoledronic Acid too, on top of Magnesium — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Magnesium and Zoledronic Acid Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Magnesium
Top 10

#7 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Zoledronic Acid
Top half

#1,059 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Magnesium

What is Magnesium?

Magnesium
  • Preventing or treating magnesium deficiency
  • Constipation
  • Muscle cramps
  • Sleep support
  • Anxiety and stress
  • Migraine prevention

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some other uses, like easing constipation or preventing migraines, have reasonable support, while uses for sleep and anxiety are less proven. It is generally safe for most healthy people at recommended amounts, but talk to your pharmacist or doctor before starting, especially if you have kidney problems.

Read the full Magnesium monograph & all interactions
Medication

About Zoledronic Acid Injection

What Is Zoledronic Acid Injection Used For?

Brand names: Zometa, Aclasta, Reclast

Zoledronic acid injection is a bisphosphonate given through a vein. The label describes two groups of uses, and not every product is used for every condition.

One group is bone conditions: osteoporosis in postmenopausal women (treatment and prevention), osteoporosis in men, glucocorticoid-induced osteoporosis (bone loss from steroid medicines), and Paget’s disease of bone. The other group is cancer-related: hypercalcemia of malignancy (high blood calcium caused by cancer), multiple myeloma, and bone metastases from solid tumors. Your prescriber chooses the specific product for your condition.

See full Zoledronic Acid Injection drug information
Keep checking

Other Drugs & Magnesium

Browse every other medication we’ve checked against Magnesium — both the ones with a known interaction and the ones without. Select any drug for the full detail.

6Major
174Moderate
114Minor
2,535No known interaction
6 Major 174 Moderate 114 Minor 2,535 No interaction
Major

6 interactions

Moderate

174 interactions

Showing 60 of 174 moderate interactions — see all 174 on the Magnesium page.

Minor

114 interactions

Showing 60 of 114 minor interactions — see all 114 on the Magnesium page.

No interaction 2,535 drugs checked — show the list

We also checked Magnesium against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,535 medications checked with no known interaction — see the full Magnesium list.

See the full Magnesium interactions page
See every supplement checked against Zoledronic Acid, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Magnesium monograph › Uses, safety, and every drug interaction in one place Zoledronic Acid supplement interactions › Every supplement checked against Zoledronic Acid, ranked by severity Zoledronic Acid Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Magnesium and Zoledronic Acid Together: Common Questions

Can you take Magnesium with Zoledronic Acid?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Magnesium and Zoledronic Acid interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Zoledronic Acid and Magnesium?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.