Drug & supplement interaction

Chokeberry + Raltegravir

Raltegravir brand name: Isentress.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Chokeberry and Raltegravir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Chokeberry and Raltegravir

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Raltegravir and Chokeberry in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Chokeberry safety at a glance

Chokeberry overall Use caution Generally well tolerated as a food, but supplement safety is not well studied.
Pregnancy Use caution Food amounts are likely fine, but concentrated supplements have not been studied, so avoid them.
Breastfeeding Use caution Little safety information exists for supplement amounts, so use caution.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Raltegravir and Chokeberry? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Raltegravir

Interactions in our licensed database are recorded against drug classes, not just single drug names. Raltegravir is filed under 4 classifications — including integrase inhibitors, glucuronidated drugs, oral drugs. Chokeberry has documented interactions with 4 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antidiabetes drugs (moderate) and cytochrome p450 3a4 (cyp3a4) substrates (moderate) — and none of Raltegravir’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Chokeberry Does Interact With Other Medications

Chokeberry has 811 moderate known drug interactions in our database — Raltegravir isn’t one of them. If you take anything else, check it against the full list below.

Moderate 811 No known interaction 2,019 (incl. Raltegravir)
Taking anything else?

Check Another of Your Medications Against Chokeberry

Covers the 2,830 medications we’ve checked against Chokeberry. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Chokeberry and Raltegravir May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Reduced appetite Additional detail

    Chokeberry

    “Orally, chokeberry juice may cause adverse gastrointestinal effects. In one small clinical study, around 14% of patients reported constipation, diarrhea, or gastrointestinal motility issues while drinking 100 mL of chokeberry juice daily for 90 days.”

    Chokeberry · Natural Medicines adverse-effect record, reported in constipation.

    2 sources cited
    1. 92375. Savikin K, Menkovic N, Zdunic G, Pljevljakusic D, Spasic S, Kardum N, Konic-Ristic A. Dietary supplementation with polyphenol-rich chokeberry juice improves skin morphology in cellulite. J Med Food. 2014 May;17(5):582-7. PubMed
    2. 111119. Lackner S, Sconocchia T, Ziegler T, et al. Immunomodulatory effects of aronia juice polyphenols-results of a randomized placebo-controlled human intervention study and cell culture experiments. Antioxidants (Basel) 2022;11(7):1283. PubMed

    Raltegravir

    Listed in the ADVERSE REACTIONS section of the FDA label for Raltegravir. Read the label on DailyMed ›

  • Stomach pain / Diarrhea / Vomiting / Nausea Additional detail

    Chokeberry

    “Orally, chokeberry seems to be well tolerated.

    Most Common Adverse Effects:

    Orally: Constipation, diarrhea, nausea, stomach cramps, vomiting.”

    Chokeberry · Natural Medicines adverse-effect record, reported in constipation.

    Raltegravir

    Listed in the ADVERSE REACTIONS section of the FDA label for Raltegravir. Read the label on DailyMed ›

Reported for Chokeberry but not commonly for Raltegravir: constipation.

Effects for Raltegravir come from the ADVERSE REACTIONS section of its FDA label; effects for Chokeberry come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 16,361 voluntary FDA FAERS reports for Raltegravir that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Raltegravir Is Prescribed For, and What Chokeberry Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Raltegravir is a prescription medicine with approved uses on its FDA label. Chokeberry is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Raltegravir is prescribed for: Raltegravir — available as Isentress and as the generic raltegravir tablet — is used to treat HIV-1 (human immunodeficiency virus) infection. It is always used together with other antiretroviral (anti-HIV) medicines, never on its own. Isentress is approved for adults and for children weighing at least 2 kg. Raltegravir tablets are approved for adults and for children weighing at least 25 kg who can swallow a tablet whole.

Chokeberry has been studied for:

  • Cancer studied, not established Chokeberry has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Chokeberry for cancer

    Although there has been interest in using oral chokeberry for cancer, there is insufficient reliable information about the clinical effects of chokeberry for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Raltegravir on your own; if you are taking Chokeberry for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Raltegravir

This page covers Chokeberry only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Raltegravir page lists 33 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Breadfruit (moderate), Brussels Sprout (moderate), Cabbage (moderate) and Calcium (moderate).

By severity: 1 major · 22 moderate · 10 minor.

From our pharmacist’s overview on the Raltegravir page

“For someone taking raltegravir (Isentress) to keep HIV suppressed, a steady drug level is what blocks rebound and resistance, and this list deserves genuine vigilance. The lone major-rated entry is activated charcoal, which can soak up the medicine in the gut and cut what reaches your blood.”

Reviewed by 2 · Jul 18, 2026

Open the Raltegravir interaction page

One more smart check

Taking Chokeberry as Part of a Dietary Supplement Product? Check It for Interactions

We hold 493 real supplement products containing Chokeberry, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Chokeberry. Even though Chokeberry itself has no known interaction with Raltegravir, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Chokeberry and Raltegravir Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Chokeberry
Top half

#457 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Raltegravir
Steady interest

#2,030 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Chokeberry reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Chokeberry and Raltegravir records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Chokeberry

What is Chokeberry?

Chokeberry
  • Antioxidant support
  • Heart and blood vessel health
  • Blood pressure support
  • Blood sugar support
  • Common cold symptoms
  • Anti-inflammatory support

Chokeberry (aronia) is a dark berry rich in antioxidants called polyphenols, and it's widely eaten as juice, jam, and supplements. Early research hints it may support heart health, blood pressure, and blood sugar, but the evidence is still limited and far from proven. It's generally well tolerated as a food, but talk to your pharmacist or doctor before using concentrated supplements.

Aronia melanocarpa · Rosaceae · Fruit (berries); sometimes leaves · Juice, syrup, tea, dried berries, powder, capsules, extracts, jams, and wines

An interaction check asks whether these two react with each other — it does not ask whether Chokeberry is a good idea for someone in your situation. Here is what our Chokeberry record says about it on its own.

Chokeberry: dosing

There is no established standard dose for chokeberry. Studies have used different forms, including juice, powders, and extracts, at varying amounts, so it's hard to recommend one precise dose.If you use a chokeberry supplement, follow the directions on the product label and do not exceed the recommended amount.

From our Chokeberry monograph — the full record covers uses, side effects and every documented interaction.

Read the full Chokeberry monograph & all interactions
Medication

About Raltegravir

What Is Raltegravir Used For?

Brand name: Isentress

Raltegravir — available as Isentress and as the generic raltegravir tablet — is used to treat HIV-1 (human immunodeficiency virus) infection. It is always used together with other antiretroviral (anti-HIV) medicines, never on its own.

Isentress is approved for adults and for children weighing at least 2 kg. Raltegravir tablets are approved for adults and for children weighing at least 25 kg who can swallow a tablet whole.

Most-Reported Side Effects for Raltegravir

From FAERS, the FDA’s public side-effect reporting system (16,418 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Foetal exposure during pregnancy 1,078 reports
Depression 1,017 reports
Anxiety 966 reports
Emotional distress 789 reports
Anhedonia 708 reports
See full Raltegravir drug information
Keep checking

Other Drugs & Chokeberry

Browse every other medication we’ve checked against Chokeberry — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
811Moderate
0Minor
2,018No known interaction
811 Moderate 2,018 No interaction
Moderate

811 interactions

Showing 60 of 811 moderate interactions — see all 811 on the Chokeberry page.

No interaction 2,018 drugs checked — show the list

We also checked Chokeberry against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,018 medications checked with no known interaction — see the full Chokeberry list.

See the full Chokeberry interactions page
See every supplement checked against Raltegravir, ranked by severity
Evidence & sources

Chokeberry References

The 8 references that drive our Chokeberry monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Sikora J, Broncel M, Markowicz M, Chalubinski M, Wojdan K, Mikiciuk-Olasik E. Short-term supplementation with Aronia melanocarpa extract improves platelet aggregation, clotting, and fibrinolysis in patients with metabolic syndrome. Eur J Nutr. 2012 Aug;51 PubMed
  2. Simeonov SB, Botushanov NP, Karahanian EB, Pavlova MB, Husianitis HK, Troev DM. Effects of Aronia melanocarpa juice as part of the dietary regimen in patients with diabetes mellitus. Folia Med (Plovdiv). 2002;44(3):20-3.
  3. Savikin K, Menkovic N, Zdunic G, Pljevljakusic D, Spasic S, Kardum N, Konic-Ristic A. Dietary supplementation with polyphenol-rich chokeberry juice improves skin morphology in cellulite. J Med Food. 2014 May;17(5):582-7. PubMed
  4. Bräunlich M, Christensen H, Johannesen S, Slimestad R, Wangensteen H, Malterud KE, Barsett H. In vitro inhibition of cytochrome P450 3A4 by Aronia melanocarpa constituents. Planta Med. 2013 Jan;79(2):137-41. PubMed
  5. Strippoli S, Lorusso V, Albano A, Guida M. Herbal-drug interaction induced rhabdomyolysis in a liposarcoma patient receiving trabectedin. BMC Complement Altern Med. 2013 Jul 30;13:199. PubMed
  6. Ryszawa N, Kawczynska-Drózdz A, Pryjma J, Czesnikiewicz-Guzik M, Adamek-Guzik T, Naruszewicz M, Korbut R, Guzik TJ. Effects of novel plant antioxidants on platelet superoxide production and aggregation in atherosclerosis. J Physiol Pharmacol. 2006 Dec;57(
  7. Milutinovic M, Velickovic Radovanovic R, Savikin K, et al. Chokeberry juice supplementation in type 2 diabetic patients - impact on health status. J Appl Biomed 2019;17(4):218-224. PubMed
  8. Lackner S, Sconocchia T, Ziegler T, et al. Immunomodulatory effects of aronia juice polyphenols-results of a randomized placebo-controlled human intervention study and cell culture experiments. Antioxidants (Basel) 2022;11(7):1283. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Chokeberry and Raltegravir Together: Common Questions

Is it safe to take Chokeberry with Raltegravir?
We do not list a known interaction between Chokeberry and Raltegravir. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Chokeberry and Raltegravir have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Chokeberry and Raltegravir used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Chokeberry in each. That is a conversation for your prescriber, especially if Raltegravir is being adjusted to a target.
How was the Chokeberry and Raltegravir combination checked?
Interactions in our licensed database are recorded against drug classes. Raltegravir is filed under 4 classifications, and Chokeberry has documented interactions with 4 drug classes — none of Raltegravir's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Chokeberry interact with any other medications?
Yes. Chokeberry has 811 documented drug interactions in our database — Raltegravir is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Raltegravir interact with any supplements?
Yes. Raltegravir has documented interactions with 33 supplements in our database — Chokeberry is not one of them. The Raltegravir interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Chokeberry monograph Uses, safety profile, and every drug interaction in one place Raltegravir drug information The full plain-English guide to this medication Raltegravir supplement interactions Every supplement checked against Raltegravir, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Raltegravir and Chokeberry?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.