Clubmoss - Tolvaptan Interaction
Herbal: Clubmoss
Also Known As: Lycopodium clavatum, Club Moss, Common Clubmoss, Common Club Moss, Lycopode, Lycopode en Massue, Licopodio, Lycopodium, Running Clubmoss, Running Pine, Shen Jin Cao, Stags Horn, Vegetable Sulfur, Witch Meal, Wolfs Claw
Drug: Tolvaptan
Brand names:
Samsca, Jynarque
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
Jun 22, 2025
Interaction Details
There were no interactions found between Tolvaptan and Clubmoss. This does not mean the potential for an interaction does not exist, however. There is often a lack of studies and data surrounding traditional medicine, especially concerning drug interactions, so it is important to always consult your provider before making any changes to your medication regimen.
Clubmoss Overview
Clubmoss, also known as lycopodium, is a plant that belongs to the Lycopodiaceae family. Clubmosses are native to many parts of the world, including North America, Europe, and Asia, and are known for their small, fern-like leaves and spore-producing structures.
Clubmoss, both the plant and spores, has a long history of use in traditional medicine and herbal remedies. The plant is believed to have a number of medicinal properties and is used to treat a variety of conditions, including bladder and kidney disorders, respiratory problems, digestive issues, and skin irritation. Some studies suggest it may also have anti-inflammatory and antioxidant effects. Clubmoss needs to be used cautiously as it contains potentially toxic alkaloids, including lycopodine, dihydrolycopodine, and traces of nicotine.
Tolvaptan Overview
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Tolvaptan (Jynarque) is used to slow the worsening of kidney function in certain patients with autosomal dominant polycystic kidney disease (ADPKD; a certain type of inherited kidney disease). Tolvaptan (Jynarque) is in a class of medications called vasopressin V2 receptor antagonists. It works by increasing the amount of water released from the body as urine and decreases the growth of cysts in the kidneys. Removing fluid from the body and slowing the growth of cysts helps to slow the worsening of kidney function.
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Tolvaptan is also available as a tablet (Samsca) to treat low blood levels of sodium in people who have heart failure or certain other conditions. This monograph only gives information about tolvaptan tablets (Jynarque) to slow the worsening of kidney function in patients with ADPKD. If you are using this medication to treat low levels of sodium in the blood, read the monograph entitled tolvaptan (low blood sodium).
Clubmoss - More Interactions
Clubmoss interacts with 216 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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