Drug & supplement interaction

Cocoa + Insulin (rDNA)

Insulin (rDNA) brand names: Humalog, Humalog Mix 75/25, Humulin R, Humulin N, Humulin L, and others.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 20, 2026

The bottom line No known interaction

We found no known interaction between Cocoa and Insulin (rDNA) in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Insulin (rDNA) states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Cocoa and Insulin (rDNA)

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Insulin (rDNA) and Cocoa in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Cocoa safety at a glance

Cocoa overall Use caution Cocoa in food amounts is generally safe, but it contains caffeine and related stimulants, and chocolate products are often high in sugar and calories.

Pregnancy Possibly Safe When used orally in moderate amounts. However, due to the caffeine content of cocoa preparations, intake should be closely monitored during pregnancy to ensure... Read the full pregnancy detail

Breastfeeding Possibly Safe When used in moderate amounts or in amounts commonly found in foods. Due to the caffeine content of cocoa preparations, intake should be closely monitored while... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Insulin (rDNA) and Cocoa? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Insulin (rDNA)

Interactions in our licensed database are recorded against drug classes, not just single drug names. Insulin (rDNA) is filed under 2 classifications — including antidiabetes drugs. Cocoa has documented interactions with 37 drug classes — the most serious being ace inhibitors (aceis) (moderate), adenosine (adenocard) (moderate) and alcohol (ethanol) (moderate) — and none of Insulin (rDNA)’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Cocoa Does Interact With Other Medications

Cocoa has 635 moderate, 26 minor known drug interactions in our database — Insulin (rDNA) isn’t one of them. If you take anything else, check it against the full list below.

Moderate 635 Minor 26 No known interaction 2,169 (incl. Insulin (rDNA))

Taking anything else?

Check Another of Your Medications Against Cocoa

Covers the 2,830 medications we’ve checked against Cocoa. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Cocoa and Insulin (rDNA) May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

A fast or pounding heartbeat Additional detail

Cocoa

“Orally and topically, cocoa is generally well tolerated.

Most Common Adverse Effects:

Orally: Borborygmi, constipation, diuresis, gastrointestinal discomfort, headaches, and nausea.

Serious Adverse Effects (Rare):

Orally: Tachycardia.”

Cocoa · Natural Medicines adverse-effect record, reported in constipation.

Insulin (rDNA)

Listed in the ADVERSE REACTIONS section of the FDA label for Insulin (rDNA). Read the label on DailyMed ›
A skin rash Additional detail
Cocoa
“In some cases, when taken orally, cocoa can cause allergic skin reactions. Topically, cocoa butter has occasionally caused a rash. In animals, it has been shown to block pores and cause acne; however, this has not been found in humans (11).”

Cocoa · Natural Medicines adverse-effect record, reported in acne.
2 sources cited

13161. Vlachopoulos C, Aznaouridis K, Alexopoulos N, et al. Effect of dark chocolate on arterial function in healthy individuals. Am J Hypertens 2005;18:785-91.. PubMed

11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
Insulin (rDNA)

Listed in the ADVERSE REACTIONS section of the FDA label for Insulin (rDNA). Read the label on DailyMed ›

Reported for Cocoa but not commonly for Insulin (rDNA): stomach upset, heartburn, constipation and bloating or gas.

Effects for Insulin (rDNA) come from the ADVERSE REACTIONS section of its FDA label; effects for Cocoa come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Cocoa in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When used orally in moderate amounts. However, due to the caffeine content of cocoa preparations, intake should be closely monitored during pregnancy to ensure moderate consumption. Fetal blood concentrations of caffeine approximate maternal concentrations. Some research has found that intrauterine exposure to even modest amounts of caffeine, based on maternal blood levels during the first trimester, is associated with a shorter stature in children ages 4-8 years. While many cocoa products contain only small amounts of caffeine (about 2-35 mg per serving), unsweetened, dry cocoa powder can contain up to 198 mg of caffeine per cup. According to a review by Health Canada, and a subsequent large meta-analysis conducted in the US, doses of up to 300 mg daily can be consumed during pregnancy without an increased risk of spontaneous abortion, still birth, preterm birth, fetal growth retardation, or congenital malformations. To be on the safe side, cocoa should be used in amounts that provide less than 300 mg of caffeine daily. Keep in mind that only the amount of ADDED caffeine must be stated on product labels. The amount of caffeine found in ingredients such as cocoa, which naturally contains caffeine, does not need to be provided. This can make it difficult to determine the total amount of caffeine in a given product.

Pregnancy Possibly Unsafe

When used orally in large amounts. Caffeine found in cocoa crosses the placenta producing fetal blood concentrations similar to maternal levels. Consumption of caffeine in amounts over 300 mg daily is associated with a significantly increased risk of miscarriage in some studies. Additionally, high intake of caffeine during pregnancy have been associated with premature delivery, low birth weight, and loss of the fetus. While many cocoa products contain only small amounts of caffeine (about 2-35 mg per serving), unsweetened, dry cocoa powder can contain up to 198 mg of caffeine per cup. To be on the safe side, cocoa should be used in amounts that provide less than 300 mg of caffeine daily. Keep in mind that only the amount of ADDED caffeine must be stated on product labels. The amount of caffeine found in ingredients such as cocoa, which naturally contains caffeine, does not need to be provided. This can make it difficult to determine the total amount of caffeine in a given product. Cocoa and dark chocolate products worldwide also contain heavy metals such as lead and cadmium. In the US, one ounce (approximately 28 grams) of most commercially available dark chocolate products tested contained levels of lead and/or cadmium above the maximum allowable dose level for California, with cadmium levels generally increasing with the percentage of cocoa. Large doses or excessive intake of cocoa should be avoided during pregnancy.

Lactation Possibly Safe

When used in moderate amounts or in amounts commonly found in foods. Due to the caffeine content of cocoa preparations, intake should be closely monitored while breastfeeding. During lactation, breast milk concentrations of caffeine are thought to be approximately 50% of serum concentrations. Moderate consumption of cocoa would likely result in very small amounts of caffeine exposure to a nursing infant. Keep in mind that only the amount of ADDED caffeine must be stated on product labels. The amount of caffeine found in ingredients such as cocoa, which naturally contains caffeine, does not need to be provided. This can make it difficult to determine the total amount of caffeine in a given product.

Lactation Possibly Unsafe

When used orally in large amounts. Consumption of excess chocolate (16 oz per day) may cause irritability and increased bowel activity in the infant. Cocoa and dark chocolate products worldwide also contain heavy metals such as lead and cadmium. In the US, one ounce (approximately 28 grams) of most commercially available dark chocolate products tested contained levels of lead and/or cadmium above the maximum allowable dose level for California, with cadmium levels generally increasing with the percentage of cocoa. Large doses or excessive intake of cocoa should be avoided during lactation.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Insulin (rDNA) Products Have a Food Rule — Cocoa Should Not Break It

At least one FDA label for a product containing Insulin (rDNA) says to take it with food. If you take Cocoa on an empty stomach out of habit, keep them separate — and take Insulin (rDNA) with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Insulin (rDNA) products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.1 , 2.2 , 2.3 , 2.4 ) Subcutaneous injection ( 2.2 ): Administer HUMALOG ® U-100 or U-200 by subcutaneous injection into the abdominal wall, thigh, upper arm, or buttocks within 15 minutes before a meal or immediately after a meal.

From the Dosage and Administration section of the FDA label we read for Insulin (rDNA) — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Overlapping uses

What Insulin (rDNA) Is Prescribed For, and What Cocoa Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Insulin (rDNA) is a prescription medicine with approved uses on its FDA label. Cocoa is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Insulin (rDNA) is prescribed for: Insulin lispro injection is used to improve glycemic control (blood sugar management) in people with diabetes mellitus. It is a rapid-acting insulin analog approved for use in both type 1 and type 2 diabetes. Admelog is specifically indicated to improve glycemic control in patients with diabetes mellitus. Humalog Mix75/25 is indicated to improve glycemic control in adults with diabetes mellitus; it is a fixed-ratio mixture of insulin lispro and insulin lispro protamine, and its fixed proportions do not allow for separate adjustment of basal (background) and prandial (mealtime) doses.

Cocoa has been studied for:

Stroke studied, not established Cocoa has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Cocoa for stroke

It is unclear if dietary cocoa is beneficial for stroke prevention.
Diabetes studied, not established Cocoa has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

Cocoa for diabetes

Several small clinical studies suggest that oral cocoa may cause small but clinically insignificant improvements in glycemic control in patients with diabetes. However, cocoa does not appear to be beneficial for the prevention of diabetes.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Insulin (rDNA) on your own; if you are taking Cocoa for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Insulin (rDNA)

This page covers Cocoa only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Insulin (rDNA) page lists 242 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Chelation Therapy Products (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 211 moderate · 29 minor.

From our pharmacist’s overview on the Insulin (rDNA) page

“A weed called Siberian cocklebur has caused severe low blood sugar in humans and is the one ingredient to avoid outright while using insulin (rDNA) products like Humalog or Humulin. This list deserves real respect.”

Reviewed by 2 · Jul 18, 2026

Open the Insulin (rDNA) interaction page

One more smart check

Taking Cocoa as Part of a Dietary Supplement Product? Check It for Interactions

We hold 844 real supplement products containing Cocoa, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Cocoa. Even though Cocoa itself has no known interaction with Insulin (rDNA), another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Cocoa and Insulin (rDNA) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Cocoa

Top 25%

#183 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Insulin (rDNA)

Top half

#1,226 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Cocoa reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Cocoa and Insulin (rDNA) records this page draws on were last updated July 11, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Cocoa

What is Cocoa?

Heart and blood vessel health
High blood pressure
High cholesterol
Mental focus and mood
Skin moisturizing (cocoa butter)

Cocoa is rich in plant compounds called flavanols that may modestly support blood vessel function and blood pressure, but most chocolate products are high in sugar, fat, and calories, which can offset any benefit. Enjoy cocoa as part of a balanced diet, and talk to your pharmacist before using concentrated cocoa supplements, especially if you have heart or blood pressure conditions.

Theobroma cacao · Malvaceae · Seeds (cocoa beans), and the butter (fat) and powder made from them · Cocoa powder, dark chocolate, cocoa extract capsules, flavanol-standardized supplements, cocoa butter (topical)

An interaction check asks whether these two react with each other — it does not ask whether Cocoa is a good idea for someone in your situation. Here is what our Cocoa record says about it on its own.

Cocoa: dosing

There is no official standard dose for cocoa. Amounts used in research vary widely, and supplements differ in how much flavanol they contain.If you use a cocoa or cocoa flavanol supplement, follow the directions on the product label.

From our Cocoa monograph — the full record covers uses, side effects and every documented interaction.

Read the full Cocoa monograph & all interactions

Medication

About Insulin Lispro Injection

What Is Insulin Lispro Injection Used For?

Brand names: Humalog, Humalog Mix 75/25, Humulin R, Humulin N, Humulin L, Humulin 50/50, Humulin 70/30, Humulin U, NovoLog, Velosulin, Novolog Mix 70/30, Actrapid, Humulin S, Insuman Rapid

Insulin lispro injection is used to improve glycemic control (blood sugar management) in people with diabetes mellitus. It is a rapid-acting insulin analog approved for use in both type 1 and type 2 diabetes.

Admelog is specifically indicated to improve glycemic control in patients with diabetes mellitus. Humalog Mix75/25 is indicated to improve glycemic control in adults with diabetes mellitus; it is a fixed-ratio mixture of insulin lispro and insulin lispro protamine, and its fixed proportions do not allow for separate adjustment of basal (background) and prandial (mealtime) doses.

See full Insulin Lispro Injection drug information

Keep checking

Other Drugs & Cocoa

Browse every other medication we’ve checked against Cocoa — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

635Moderate

26Minor

2,168No known interaction

635 Moderate 26 Minor 2,168 No interaction

Moderate

635 interactions

Showing 60 of 635 moderate interactions — see all 635 on the Cocoa page.

Minor

26 interactions

No interaction 2,168 drugs checked — show the list

We also checked Cocoa against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,168 medications checked with no known interaction — see the full Cocoa list.

See the full Cocoa interactions page

See every supplement checked against Insulin (rDNA), ranked by severity

Evidence & sources

Cocoa References

The 119 references that drive our Cocoa monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
Harder S, Fuhr U, Staib AH, Wolff T. Ciprofloxacin-caffeine: a drug interaction established using in vivo and in vitro investigations. Am J Med 1989;87:89S-91S. PubMed
Carbo M, Segura J, De la Torre R, et al. Effect of quinolones on caffeine disposition. Clin Pharmacol Ther 1989;45:234-40. PubMed
Healy DP, Polk RE, Kanawati L, et al. Interaction between oral ciprofloxacin and caffeine in normal volunteers. Antimicrob Agents Chemother 1989;33:474-8. PubMed
Mester R, Toren P, Mizrachi I, et al. Caffeine withdrawal increases lithium blood levels. Biol Psychiatry 1995;37:348-50. PubMed
Jefferson JW. Lithium tremor and caffeine intake: two cases of drinking less and shaking more. J Clin Psychiatry 1988;49:72-3.
Joeres R, Klinker H, Heusler H, et al. Influence of mexiletine on caffeine elimination. Pharmacol Ther 1987;33:163-9. PubMed
Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
Baron AM, Donnerstein RL, Samson RA, et al. Hemodynamic and electrophysiologic effects of acute chocolate ingestion in young adults. Am J Cardiol 1999;84:370-3. PubMed
Friedman G. Diet and the irritable bowel syndrome. Gastroenterol Clin North Am 1991;20:313-24. DOI
The National Toxicology Program (NTP). Caffeine. Center for the Evaluation of Risks to Human Reproduction (CERHR). Available at: http://cerhr.niehs.nih.gov/common/caffeine.html.
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Weisburger JH. Tea and health: the underlying mechanisms. Proc Soc Exp Biol Med 1999;220:271-5. PubMed
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Hagg S, Spigset O, Mjorndal T, Dahlqvist R. Effect of caffeine on clozapine pharmacokinetics in healthy volunteers. Br J Clin Pharmacol 2000;49:59-63. PubMed
American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 2001;108:776-89. PubMed
Dietrich R, Paglieroni TG, Wun T, et al. Cocoa inhibits platelet activation and function. Am J Clin Nutr 2000;72:30-5. PubMed
Sinclair CJ, Geiger JD. Caffeine use in sports. A pharmacological review. J Sports Med Phys Fitness 2000;40:71-9.
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Vlachopoulos C, Aznaouridis K, Alexopoulos N, et al. Effect of dark chocolate on arterial function in healthy individuals. Am J Hypertens 2005;18:785-91.. PubMed
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Forrest WH Jr, Bellville JW, Brown BW Jr. The interaction of caffeine with pentobarbital as a nighttime hypnotic. Anesthesiology 1972;36:37-41. PubMed
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Grassi D, Necozione S, Lippi C, et al. Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives. Hypertension 2005;46:398-405. PubMed
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Taubert D, Roesen R, Lehmann C, et al. Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: a randomized controlled trial. JAMA 2007;298:49-60. PubMed
Weng X, Odouli R, Li DK. Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study. Am J Obstet Gynecol 2008;198:279.e1-8. PubMed
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Hooper L, Kay C, Abdelhamid A, et al. Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials. Am J Clin Nutr 2012;95:740-51. PubMed
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Goh BC, Reddy NJ, Dandamudi UB, et al. An evaluation of the drug interaction potential of pazopanib, an oral vascular endothelial growth factor receptor tyrosine kinase inhibitor, using a modified Cooperstown 5+1 cocktail in patients with advanced solid t
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Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Related: nutrient depletion

Insulin (rDNA) Is Linked to Lower Levels of 2 Nutrients

Natural Medicines records Insulin (rDNA) as a medicine that can lower these. This is not an interaction with Cocoa — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:

Read the full Insulin (rDNA) nutrient depletion report ›

Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.

Pharmacist Counseling Corner

Taking Cocoa and Insulin (rDNA) Together: Common Questions

Is it safe to take Cocoa with Insulin (rDNA)?

We do not list a known interaction between Cocoa and Insulin (rDNA). That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

Do Cocoa and Insulin (rDNA) have any of the same side effects?

Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.

Should I take Cocoa and Insulin (rDNA) at the same time of day?

At least one FDA label for a product containing Insulin (rDNA) says to take it with food. If you take Cocoa on an empty stomach out of habit, keep them separate and take Insulin (rDNA) with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Insulin (rDNA) products can differ — so check the directions on your own box. This is about absorption, not an interaction.

Are Cocoa and Insulin (rDNA) used for the same thing?

They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Cocoa in each. That is a conversation for your prescriber, especially if Insulin (rDNA) is being adjusted to a target.

How was the Cocoa and Insulin (rDNA) combination checked?

Interactions in our licensed database are recorded against drug classes. Insulin (rDNA) is filed under 2 classifications, and Cocoa has documented interactions with 37 drug classes — none of Insulin (rDNA)'s classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Cocoa interact with any other medications?

Yes. Cocoa has 661 documented drug interactions in our database — Insulin (rDNA) is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Insulin (rDNA) interact with any supplements?

Yes. Insulin (rDNA) has documented interactions with 242 supplements in our database — Cocoa is not one of them. The Insulin (rDNA) interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.