Drug & supplement interaction

Coltsfoot + Cyclosporine

Cyclosporine brand names: Neoral, Gengraf, Sandimmune, Ciclosporine, Cequa, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Coltsfoot and Cyclosporine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Coltsfoot and Cyclosporine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cyclosporine and Coltsfoot in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Coltsfoot safety at a glance

Coltsfoot overall Use caution May contain liver-toxic pyrrolizidine alkaloids; use only certified PA-free products, if at all.
Pregnancy Likely Unsafe When products containing hepatotoxic pyrrolizidine alkaloid (PA) constituents are used orally. Coltsfoot preparations containing hepatotoxic pyrrolizidine alkal... Read the full pregnancy detail
Breastfeeding Likely Unsafe When used orally. Hepatotoxic pyrrolizidine alkaloid (PA) constituents in coltsfoot are excreted in milk. There is insufficient reliable information available a... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cyclosporine and Coltsfoot? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Cyclosporine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cyclosporine is filed under 10 classifications — including immunosuppressants, cytochrome p450 3a4 (cyp3a4) inhibitors, topical drugs. Coltsfoot has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antihypertensive drugs (moderate) and cytochrome p450 3a4 (cyp3a4) inducers (moderate) — and none of Cyclosporine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Coltsfoot Does Interact With Other Medications

Coltsfoot has 374 moderate known drug interactions in our database — Cyclosporine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 374 No known interaction 2,456 (incl. Cyclosporine)
Taking anything else?

Check Another of Your Medications Against Coltsfoot

Covers the 2,830 medications we’ve checked against Coltsfoot. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Coltsfoot and Cyclosporine May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 3 of them are worth acting on rather than waiting out — marked below.

  • Blood clots Worth acting on Additional detail

    Coltsfoot

    “Orally, the major concern with coltsfoot use is its pyrrolizidine alkaloid (PA) content. These alkaloids can cause liver and lung injury. Chronic exposure to other plants containing hepatotoxic PA constituents has been associated with hepatic veno-occlusive disease. Sub-acute veno-occlusive disease can cause vague symptoms, including colicky pains, vomiting, diarrhea, and ascites within several days;”

    Coltsfoot · Natural Medicines adverse-effect record, reported in diarrhea.

    4 sources cited
    1. 12841. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
    2. 12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
    3. 4021. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
    4. 18242. Freshour JE, Odle B, Rikhye S, Stewart DW. Coltsfoot as a potential cause of deep vein thrombosis and pulmonary embolism in a patient also consuming kava and blue vervain. J Diet Suppl 2012;9:149-54. PubMed

    “Orally, a single case report associates coltsfoot and its PA content with deep vein thrombosis (DVT) and pulmonary embolus (PE). A 27-year-old man with no history of coagulation disorders developed a DVT and several PE after consuming unknown quantities of coltsfoot and several other herbs. However, he also had other risk factors for thrombosis, including smoking and recent bed rest.”

    Coltsfoot · Natural Medicines adverse-effect record, reported in venous thromboembolism (vte).

    1 source cited
    1. 18242. Freshour JE, Odle B, Rikhye S, Stewart DW. Coltsfoot as a potential cause of deep vein thrombosis and pulmonary embolism in a patient also consuming kava and blue vervain. J Diet Suppl 2012;9:149-54. PubMed

    Cyclosporine

    Listed in the ADVERSE REACTIONS section of the FDA label for Cyclosporine. Read the label on DailyMed ›

  • Raised blood pressure Worth acting on Additional detail

    Coltsfoot

    “Orally, coltsfoot might cause lung damage. The major concern with coltsfoot use is its pyrrolizidine alkaloid (PA) content. These constituents can cause lung damage with pulmonary-arterial hypertension.”

    Coltsfoot · Natural Medicines adverse-effect record, reported in hypertension.

    2 sources cited
    1. 12841. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
    2. 12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.

    Cyclosporine

    Listed in the ADVERSE REACTIONS section of the FDA label for Cyclosporine. Read the label on DailyMed ›

  • Liver problems Worth acting on Additional detail

    Coltsfoot

    “Orally, coltsfoot might cause liver damage. Coltsfoot contains hepatotoxic pyrrolizidine alkaloids (PAs). Chronic exposure to other plants containing hepatotoxic PAs is associated with veno-occlusive disease. Sub-acute veno-occlusive disease can cause vague symptoms, including colicky pains, vomiting, diarrhea, and ascites within several days; persistent liver enlargement occurs within a few weeks.”

    Coltsfoot · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 12841. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
    2. 12842. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
    3. 4021. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.

    Cyclosporine

    Listed in the ADVERSE REACTIONS section of the FDA label for Cyclosporine. Read the label on DailyMed ›

  • Diarrhea / Vomiting Additional detail

    Coltsfoot

    Recorded for Coltsfoot in the same Natural Medicines adverse-effect record shown under Blood clots above.

    Cyclosporine

    Listed in the ADVERSE REACTIONS section of the FDA label for Cyclosporine. Read the label on DailyMed ›

Effects for Cyclosporine come from the ADVERSE REACTIONS section of its FDA label; effects for Coltsfoot come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Coltsfoot in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When products containing hepatotoxic pyrrolizidine alkaloid (PA) constituents are used orally. Coltsfoot preparations containing hepatotoxic pyrrolizidine alkaloid (PA) constituents might be teratogenic and hepatotoxic. There is one case report of fatal hepatic veno-occlusive disease in a neonate associated with regular maternal consumption during pregnancy of an herb tea containing several pyrrolizidine alkaloid herbs, including coltsfoot. There is insufficient reliable information available about the safety of using coltsfoot products certified and labeled as hepatotoxic PA-free during pregnancy; avoid using.

Lactation Likely Unsafe

When used orally. Hepatotoxic pyrrolizidine alkaloid (PA) constituents in coltsfoot are excreted in milk. There is insufficient reliable information available about the safety of using coltsfoot products certified and labeled as hepatotoxic PA-free during lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Coltsfoot or Cyclosporine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Coltsfoot or Cyclosporine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Cyclosporine

This page covers Coltsfoot only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cyclosporine page lists 229 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Berberine (major) and Grapefruit (major).

By severity: 9 major · 182 moderate · 38 minor.

From our pharmacist’s overview on the Cyclosporine page

“Cyclosporine (Neoral, Sandimmune, Gengraf) keeps a transplanted organ from being rejected, and small shifts in its blood level can tip you toward rejection on one side or toxicity on the other. So approach these 229 interacting supplements with real care.”

Reviewed by 2 · Jul 18, 2026

Open the Cyclosporine interaction page

One more smart check

Taking Coltsfoot as Part of a Dietary Supplement Product? Check It for Interactions

We hold 60 real supplement products containing Coltsfoot, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Coltsfoot. Even though Coltsfoot itself has no known interaction with Cyclosporine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Coltsfoot and Cyclosporine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Coltsfoot
Steady interest

#1,104 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Cyclosporine
Top 25%

#633 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Coltsfoot reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Coltsfoot and Cyclosporine records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Coltsfoot

What is Coltsfoot?

Coltsfoot
  • Cough
  • Sore throat
  • Bronchitis and congestion
  • Loosening mucus (expectorant)
  • Asthma symptoms

Coltsfoot is a traditional herb long used to soothe coughs and clear mucus, but solid human evidence for these uses is lacking. More importantly, the raw plant can contain liver-toxic pyrrolizidine alkaloids, so it carries real safety concerns and is best avoided unless you use a product certified to be free of these compounds.

Tussilago farfara · Asteraceae · Leaves and flowers · Tea, dried herb, tincture, syrup, capsules, lozenges

An interaction check asks whether these two react with each other — it does not ask whether Coltsfoot is a good idea for someone in your situation. Here is what our Coltsfoot record says about it on its own.

Coltsfoot: dosing

There is no established, standardized dose for coltsfoot, and because of the safety concerns, no dose can be considered clearly safe. Traditional products include teas, syrups, and tinctures, but the amount of active and toxic compounds can vary widely between products.If you choose to use coltsfoot despite the risks, only use a product certified to be free of pyrrolizidine alkaloids, follow the label directions exactly, and use it for the shortest time possible.

From our Coltsfoot monograph — the full record covers uses, side effects and every documented interaction.

Read the full Coltsfoot monograph & all interactions
Medication

About Cyclosporine

What Is Cyclosporine Used For?

Brand names: Neoral, Gengraf, Sandimmune, Ciclosporine, Cequa, Verkazia, Vevye

Cyclosporine is prescribed to help prevent the body from rejecting a transplanted kidney, liver, or heart. It is often used alongside other immunosuppressive medicines as part of a full transplant care plan.

It is also used for adults with severe, active rheumatoid arthritis that hasn't responded well enough to methotrexate, and for adults with severe plaque psoriasis who haven't had success with other standard treatments.

Most-Reported Side Effects for Cyclosporine

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Eye irritation 10,005 reports
Eye pain 4,619 reports
Fever 4,174 reports
Headache 3,888 reports
Nausea 3,776 reports
See full Cyclosporine drug information
Keep checking

Other Drugs & Coltsfoot

Browse every other medication we’ve checked against Coltsfoot — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
374Moderate
0Minor
2,455No known interaction
374 Moderate 2,455 No interaction
Moderate

374 interactions

Showing 60 of 374 moderate interactions — see all 374 on the Coltsfoot page.

No interaction 2,455 drugs checked — show the list

We also checked Coltsfoot against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,455 medications checked with no known interaction — see the full Coltsfoot list.

See the full Coltsfoot interactions page
See every supplement checked against Cyclosporine, ranked by severity
Evidence & sources

Coltsfoot References

The 8 references that drive our Coltsfoot monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Roulet M, Laurini R, Rivier L, Calame A. Hepatic veno-occlusive disease in newborn infant of a woman drinking herbal tea. J Pediatr 1988;112:433-6. PubMed
  2. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  3. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  4. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  5. Wilson BE, Hobbs WN. Case report: pseudoephedrine-associated thyroid storm: thyroid hormone-catecholamine interactions. Am J Med Sci 1993;306:317-9. PubMed
  6. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  7. Hwang SB, Chang MN, Garcia ML, et al. L-652,469--a dual receptor antagonist of platelet activating factor and dihydropyridines from Tussilago farfara L. Eur J Pharmacol 1987;141:269-81. PubMed
  8. Freshour JE, Odle B, Rikhye S, Stewart DW. Coltsfoot as a potential cause of deep vein thrombosis and pulmonary embolism in a patient also consuming kava and blue vervain. J Diet Suppl 2012;9:149-54. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Coltsfoot and Cyclosporine Together: Common Questions

Is it safe to take Coltsfoot with Cyclosporine?
We do not list a known interaction between Coltsfoot and Cyclosporine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Coltsfoot and Cyclosporine have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Coltsfoot and Cyclosporine combination checked?
Interactions in our licensed database are recorded against drug classes. Cyclosporine is filed under 10 classifications, and Coltsfoot has documented interactions with 3 drug classes — none of Cyclosporine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Coltsfoot interact with any other medications?
Yes. Coltsfoot has 374 documented drug interactions in our database — Cyclosporine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Cyclosporine interact with any supplements?
Yes. Cyclosporine has documented interactions with 229 supplements in our database — Coltsfoot is not one of them. The Cyclosporine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Coltsfoot monograph Uses, safety profile, and every drug interaction in one place Cyclosporine drug information The full plain-English guide to this medication Cyclosporine supplement interactions Every supplement checked against Cyclosporine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cyclosporine and Coltsfoot?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.