Conjugated Linoleic Acid (cla) + Dextroamphetamine
Dextroamphetamine brand name: Dexedrine.
We found no known interaction between Conjugated Linoleic Acid (cla) and Dextroamphetamine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Conjugated Linoleic Acid (cla) and Dextroamphetamine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Dextroamphetamine and Conjugated Linoleic Acid (cla) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Conjugated Linoleic Acid (cla) safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Dextroamphetamine
Interactions in our licensed database are recorded against drug classes, not just single drug names. Dextroamphetamine is filed under 7 classifications — including amphetamines, stimulant drugs, serotonergic drugs. Conjugated Linoleic Acid (cla) has documented interactions with 3 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), antihypertensive drugs (moderate) and ramipril (altace) (moderate) — and none of Dextroamphetamine’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Conjugated Linoleic Acid (cla) Does Interact With Other Medications
Conjugated Linoleic Acid (cla) has 289 moderate known drug interactions in our database — Dextroamphetamine isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Conjugated Linoleic Acid (cla)
We haven’t checked that one against Conjugated Linoleic Acid (cla) yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Conjugated Linoleic Acid (cla). Pick one to open its full report.
Conjugated Linoleic Acid (cla) in Pregnancy & Breastfeeding
When used orally in amounts found in foods. There is insufficient reliable information available about the safety of CLA when used in medicinal amounts during pregnancy or lactation; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Questions About Conjugated Linoleic Acid (cla) or Dextroamphetamine
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Conjugated Linoleic Acid (cla) or Dextroamphetamine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
- Is L-Theanine Safe To Take With Dexedrine? ›
- Converting Dexedrine To Other Stimulants ›
- Taking Concerta And Vyvanse Together ›
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Dextroamphetamine
This page covers Conjugated Linoleic Acid (cla) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Dextroamphetamine page lists 129 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Ephedra (major), Lithium (major), Peyote (major) and Rauvolfia Vomitoria (major).
By severity: 6 major · 100 moderate · 23 minor.
From our pharmacist’s overview on the Dextroamphetamine page
“Dextroamphetamine (Dexedrine) is a stimulant for ADHD and narcolepsy, and I read this list with genuine wariness. Six of the 129 ingredients rate major, most of them because other stimulants, ephedra being the clearest, pile extra heart rate and blood pressure on top of what the drug already produces.”
Reviewed by 2 · Jul 18, 2026
Where Conjugated Linoleic Acid (cla) and Dextroamphetamine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,024 of 1,452 supplements looked up here in the last 7 days
#31 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Conjugated Linoleic Acid (cla) reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Conjugated Linoleic Acid (cla) and Dextroamphetamine records this page draws on were last updated July 10, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Conjugated Linoleic Acid (cla)
What is Conjugated Linoleic Acid (cla)?
- Weight loss
- Improving body composition
- Sports and muscle support
- Reducing inflammation
- General wellness
CLA is a fatty acid found naturally in meat and dairy, and supplements are usually made from safflower oil. While it is popular for fat loss and body composition, research results are mixed and any real-world effect appears small at best. It is likely safe for short-term use in most healthy adults, but talk to your pharmacist or doctor before starting it.
Fatty acid (often sourced from safflower or sunflower oil) · Softgels, capsules, oil
An interaction check asks whether these two react with each other — it does not ask whether Conjugated Linoleic Acid (cla) is a good idea for someone in your situation. Here is what our Conjugated Linoleic Acid (cla) record says about it on its own.
Conjugated Linoleic Acid (cla): dosing
There is no official or standardized dose of CLA. Doses used in studies have varied widely, and it is not clear which amount, if any, is most effective.The best approach is to follow the directions on the product label and not exceed the recommended amount.
From our Conjugated Linoleic Acid (cla) monograph — the full record covers uses, side effects and every documented interaction.
About Dextroamphetamine
What Is Dextroamphetamine Used For?
Brand name: Dexedrine
Dextroamphetamine treats two conditions: ADHD and narcolepsy (a sleep disorder causing uncontrollable daytime sleepiness). It is available in multiple forms — tablets, extended-release capsules, oral solution, and a skin patch — and the approved age ranges vary by product.
Oral tablets (Zenzedi, generic) and oral solutions (Procentra, generic) are approved for ADHD in children as young as 3 years old and for narcolepsy. Extended-release capsules (Dexedrine, generic) are approved for ADHD in children ages 6 to 16 and for narcolepsy. Xelstrym, the transdermal patch, is approved only for ADHD — in adults and children ages 6 and older — and is not indicated for narcolepsy.
Other Drugs & Conjugated Linoleic Acid (cla)
Browse every other medication we’ve checked against Conjugated Linoleic Acid (cla) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
289 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Aspirin ›
- Naproxen ›
- Minocycline ›
- Propranolol ›
- Hydrochlorothiazide ›
- Verapamil ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Hydralazine ›
- Ketoprofen ›
- Trichlormethiazide ›
- Bendroflumethiazide ›
- Bivalirudin ›
- Lisinopril ›
- Metolazone ›
- Minoxidil ›
- Nicardipine ›
- Prazosin ›
- Spironolactone ›
- Timolol ›
- Warfarin Sodium ›
- Acebutolol ›
- Acetazolamide ›
- Ambrisentan ›
- Amiloride ›
- Atenolol ›
- Betaxolol ›
- Bromfenac Sodium ›
- Candesartan Cilexetil ›
- Captopril ›
- Carteolol ›
- Carvedilol ›
- Chlorthalidone ›
- Cyclothiazide ›
- Dabigatran ›
- Diclofenac Epolamine ›
- Enalapril Maleate ›
- Felodipine ›
- Guanethidine Monosulfate ›
- Iloprost ›
- Indapamide ›
- Irbesartan ›
- Labetalol ›
- Mannitol ›
- Methyclothiazide ›
- Methyldopa ›
- Metoprolol ›
- Nadolol ›
- Nebivolol ›
- Nimodipine ›
- Olmesartan Medoxomil ›
- Oxprenolol ›
- Pindolol ›
- Piroxicam ›
- Quinapril ›
- Reserpine ›
Showing 60 of 289 moderate interactions — see all 289 on the Conjugated Linoleic Acid (cla) page.
No interaction 2,540 drugs checked — show the list
We also checked Conjugated Linoleic Acid (cla) against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Ivermectin ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Prednisone ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Oxycodone ›
- Dapsone ›
- Diazepam ›
- Cyclopentolate ›
- Cephalexin ›
- Roxithromycin ›
- Pegunigalsidase Alfa-iwxj ›
- Atorvastatin Calcium ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Daptomycin ›
- Mirtazapine ›
- Finasteride ›
- Acetaminophen, Caffeine, Codeine ›
- Hexobarbitone ›
Showing the 60 most looked-up of 2,540 medications checked with no known interaction — see the full Conjugated Linoleic Acid (cla) list.
Conjugated Linoleic Acid (cla) References
The 27 references that drive our Conjugated Linoleic Acid (cla) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Riserus U, Arner P, Brismar K, Vessby B. Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care 2002;25:1516-21.
- Blankson H, Stakkestad JA, Fagertun H, et al. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr 2000;130:2943-8. PubMed
- Gaullier JM, Halse J, Hoye K, et al. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. Am J Clin Nutr 2004;79:1118-25. PubMed
- Pariza M, Park Y, Cook ME. Conjugated linoleic acid and the control of cancer and obesity. Toxicol Sci 1999;52:107-10. DOI
- Kelly ML, Berry JR, Dwyer DA, et al. Dietary fatty acid sources affect conjugated linoleic acid concentrations in milk from lactating dairy cows. J Nutr 1998;128:881-5. PubMed
- Herbel BK, McGuire MK, McGuire MA, Shultz TD. Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans. Am J Clin Nutr 1998;67:332-7. PubMed
- Riserus U, Vessby B, Arner P, Zethelius B. Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity. Diabetologia 2004;47:1016-9. PubMed
- Nagao, K., Inoue, N., Wang, Y. M., Hirata, J., Shimada, Y., Nagao, T., Matsui, T., and Yanagita, T. The 10trans,12cis isomer of conjugated linoleic acid suppresses the development of hypertension in Otsuka Long-Evans Tokushima fatty rats. Biochem.Biophys PubMed
- Riserus, U., Vessby, B., Arnlov, J., and Basu, S. Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. Am J Clin Nutr 2004;80(2):279-283. PubMed
- Tricon, S., Burdge, G. C., Kew, S., Banerjee, T., Russell, J. J., Jones, E. L., Grimble, R. F., Williams, C. M., Yaqoob, P., and Calder, P. C. Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy huma
- Moloney, F., Yeow, T. P., Mullen, A., Nolan, J. J., and Roche, H. M. Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. Am J Clin Nutr 2004;80(4):887-895. PubMed
- Lambert, E. V., Goedecke, J. H., Bluett, K., Heggie, K., Claassen, A., Rae, D. E., West, S., Dugas, J., Dugas, L., Meltzeri, S., Charlton, K., and Mohede, I. Conjugated linoleic acid versus high-oleic acid sunflower oil: effects on energy metabolism, glu
- Tholstrup, T., Raff, M., Straarup, E. M., Lund, P., Basu, S., and Bruun, J. M. An oil mixture with trans-10, cis-12 conjugated linoleic acid increases markers of inflammation and in vivo lipid peroxidation compared with cis-9, trans-11 conjugated linolei
- Ramos, R., Mascarenhas, J., Duarte, P., Vicente, C., and Casteleiro, C. Conjugated linoleic acid-induced toxic hepatitis: first case report. Dig.Dis.Sci 2009;54(5):1141-1143. PubMed
- Ingelsson, E. and Riserus, U. Effects of trans10cis12CLA-induced insulin resistance on retinol-binding protein 4 concentrations in abdominally obese men. Diabetes Res Clin.Pract. 2008;82(3):e23-e24. PubMed
- Zhao, W. S., Zhai, J. J., Wang, Y. H., Xie, P. S., Yin, X. J., Li, L. X., and Cheng, K. L. Conjugated linoleic acid supplementation enhances antihypertensive effect of ramipril in Chinese patients with obesity-related hypertension. Am.J Hypertens. 2009;2 PubMed
- Peterson, K. M., O'Shea, M., Stam, W., Mohede, I. C., Patrie, J. T., and Hayden, F. G. Effects of dietary supplementation with conjugated linoleic acid on experimental human rhinovirus infection and illness. Antivir.Ther 2009;14(1):33-43. DOI
- Sofi, F., Buccioni, A., Cesari, F., Gori, A. M., Minieri, S., Mannini, L., Casini, A., Gensini, G. F., Abbate, R., and Antongiovanni, M. Effects of a dairy product (pecorino cheese) naturally rich in cis-9, trans-11 conjugated linoleic acid on lipid, inf
- Wanders, A. J., Brouwer, I. A., Siebelink, E., and Katan, M. B. Effect of a high intake of conjugated linoleic acid on lipoprotein levels in healthy human subjects. PLoS.One. 2010;5(2):e9000. PubMed
- Aryaeian, N., Shahram, F., Djalali, M., Eshragian, M. R., Djazayeri, A., Sarrafnejad, A., Salimzadeh, A., Naderi, N., and Maryam, C. Effect of conjugated linoleic acids, vitamin E and their combination on the clinical outcome of Iranian adults with activ
- MacRedmond, R., Singhera, G., Attridge, S., Bahzad, M., Fava, C., Lai, Y., Hallstrand, T. S., and Dorscheid, D. R. Conjugated linoleic acid improves airway hyper-reactivity in overweight mild asthmatics. Clin.Exp.Allergy 2010;40(7):1071-1078. PubMed
- Berven, G., Bye, A., and Hals, O. Safety of conjugated linoleic acid (CLA) in overweight or obese human volunteers. Eur J Lipid Sci Technol 2000;102:455-462. DOI
- Nortadas R, Barata J. Fulminant hepatitis during self-medication with conjugated linoleic acid. Ann Hepatol. 2012;11(2):265-7. DOI
- Costa I, Mendonca MD, Cruz E Silva V, Calado S, Viana-Baptista M. Herbal supplements association with reversible cerebral vasoconstriction syndrome: a case report. J Stroke Cerebrovasc Dis 2017;26(3):673-76. PubMed
- Madry E, Malesza IJ, Subramaniapillai M, et al. Body fat changes and liver safety in obese and overweight women supplemented with conjugated linoleic acid: A 12-week randomised, double-blind, placebo-controlled trial. Nutrients. 2020;12(6):1811. PubMed
- Leilami K, Kohansal A, Mohammadi Sartang M, Babajafari S, Sohrabi Z. Adverse effects of conjugated linoleic acids supplementation on circulating lipoprotein (a) levels in overweight and obese individuals: results of a systematic review and meta-analysis o
- Liang CW, Cheng HY, Lee YH, Liou TH, Liao CD, Huang SW. Effects of conjugated linoleic acid and exercise on body composition and obesity: a systematic review and meta-analysis. Nutr Rev 2023;81(4):397-415. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Conjugated Linoleic Acid (cla) and Dextroamphetamine Together: Common Questions
Is it safe to take Conjugated Linoleic Acid (cla) with Dextroamphetamine?
Do Conjugated Linoleic Acid (cla) and Dextroamphetamine have any of the same side effects?
How was the Conjugated Linoleic Acid (cla) and Dextroamphetamine combination checked?
Does Conjugated Linoleic Acid (cla) interact with any other medications?
Does Dextroamphetamine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.