Conjugated Linoleic Acid (cla) + Iloprost
Iloprost brand names: Ventavis, Aurlumyn.
Iloprost falls into 2 drug categories that Conjugated Linoleic Acid (cla) can interact with; the most serious is rated moderate. Theoretically, taking CLA with antihypertensive drugs might increase the risk of hypotension.
Read the full interaction reportConjugated Linoleic Acid (cla) and Iloprost
These two interact in 2 distinct ways. Each one is explained separately below.
Why Are There 2 Interactions?
Conjugated Linoleic Acid (cla) interacts with whole categories of medication. Iloprost falls into 2 of those categories, so it can interact with Conjugated Linoleic Acid (cla) in 2 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Moderate).
ANTIHYPERTENSIVE DRUGS
1 of 2Why this applies to Iloprost
Iloprost falls under ANTIHYPERTENSIVE DRUGS — the group Conjugated Linoleic Acid (cla) interacts with.
Animal research suggests that a particular form of CLA reduces systolic blood pressure. Also, some clinical research shows that CLA enhances the blood pressure-lowering effects of ramipril, an antihypertensive drug.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the simple version: Iloprost (Ventavis) already works by relaxing and widening your blood vessels to ease pressure in the lungs. CLA may have its own mild blood-pressure-lowering tendency, so stacking the two could nudge your pressure down a little more than expected. That can show up as lightheadedness, dizziness, fainting, flushing, or feeling unusually tired, especially when you stand up quickly.
I want to keep this in perspective. The concern is mostly theoretical and based largely on animal work and one study with a different drug (ramipril), not with iloprost itself. CLA isn't speeding up or slowing down how iloprost is broken down, so this isn't a metabolism issue. Still, if you'd like to try CLA, check with your pharmacist or doctor first and watch how you feel.
- Nagao, K., Inoue, N., Wang, Y. M., Hirata, J., Shimada, Y., Nagao, T., Matsui, T., and Yanagita, T. The 10trans,12cis isomer of conjugated linoleic acid suppresses the development of hypertension in Otsuka Long-Evans Tokushima fatty rats. Biochem.Biophys PubMed
- Zhao, W. S., Zhai, J. J., Wang, Y. H., Xie, P. S., Yin, X. J., Li, L. X., and Cheng, K. L. Conjugated linoleic acid supplementation enhances antihypertensive effect of ramipril in Chinese patients with obesity-related hypertension. Am.J Hypertens. 2009;2 PubMed
ANTICOAGULANT/ANTIPLATELET DRUGS
2 of 2Iloprost also falls under ANTICOAGULANT/ANTIPLATELET DRUGS.
Some clinical evidence suggests that intake of CLA reduces platelet aggregation by approximately 10%. The clinical significance of this effect is unclear.
Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
Here's the thing to keep in mind with this pairing. Iloprost (Ventavis) does more than relax blood vessels in your lungs, it also has a mild blood-thinning quality because it keeps platelets from clumping together. CLA, based on some early evidence, may also nudge platelets to stick together a little less, roughly a 10% drop in one study. Stack the two and, in theory, you could see a slightly higher chance of bleeding or bruising.
I want to be honest though: this is a theoretical concern based on how the two work, not something proven to cause real problems in people. Watch for easy bruising, nosebleeds, or bleeding gums, and check with your pharmacist or doctor before adding CLA. Don't change your iloprost on your own.
- Sofi, F., Buccioni, A., Cesari, F., Gori, A. M., Minieri, S., Mannini, L., Casini, A., Gensini, G. F., Abbate, R., and Antongiovanni, M. Effects of a dairy product (pecorino cheese) naturally rich in cis-9, trans-11 conjugated linoleic acid on lipid, inf
What These Ratings Mean
Every interaction above is graded three ways — here’s the key to each label.
Clinically significant. Avoid the combination, or use only under close professional supervision.
Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.
Generally not serious. Be aware of it and mention it to your pharmacist.
- LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
- ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
- UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
- AHigh-quality meta-analysis (quantitative systematic review).
- BCase-control study.
- CConsensus.
- DAnecdotal evidence.
These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.
Conjugated Linoleic Acid (cla) Also Interacts With Other Medications
Conjugated Linoleic Acid (cla) has 288 moderate known drug interactions in our database — the Iloprost one above is among them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Conjugated Linoleic Acid (cla)
We haven’t checked that one against Conjugated Linoleic Acid (cla) yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Conjugated Linoleic Acid (cla). Pick one to open its full report.
See Every Supplement That Interacts With Iloprost
This page covers Conjugated Linoleic Acid (cla) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Iloprost page lists 287 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Danshen (major) and Piracetam (major).
By severity: 6 major · 254 moderate · 27 minor.
Where Conjugated Linoleic Acid (cla) and Iloprost Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,422 of 1,452 supplements looked up here in the last 7 days
#877 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
About Conjugated Linoleic Acid (cla)
What is Conjugated Linoleic Acid (cla)?
- Weight loss
- Improving body composition
- Sports and muscle support
- Reducing inflammation
- General wellness
CLA is a fatty acid found naturally in meat and dairy, and supplements are usually made from safflower oil. While it is popular for fat loss and body composition, research results are mixed and any real-world effect appears small at best. It is likely safe for short-term use in most healthy adults, but talk to your pharmacist or doctor before starting it.
About Iloprost
What Is Iloprost Used For?
Brand names: Ventavis, Aurlumyn
Aurlumyn (iloprost injection) is FDA-approved to treat severe frostbite in adults. Specifically, it is used to reduce the risk of losing fingers or toes (digit amputation) after serious frostbite injury. The clinical evidence supporting this use comes from young, healthy adults who suffered frostbite at high altitudes.
Other Drugs & Conjugated Linoleic Acid (cla)
Browse every other medication we’ve checked against Conjugated Linoleic Acid (cla) — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
288 interactions
- Diclofenac Sodium ›
- Diltiazem ›
- Nifedipine ›
- Ibuprofen ›
- Aspirin ›
- Naproxen ›
- Minocycline ›
- Propranolol ›
- Hydrochlorothiazide ›
- Verapamil ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Hydralazine ›
- Ketoprofen ›
- Trichlormethiazide ›
- Bendroflumethiazide ›
- Bivalirudin ›
- Lisinopril ›
- Metolazone ›
- Minoxidil ›
- Nicardipine ›
- Prazosin ›
- Spironolactone ›
- Timolol ›
- Warfarin Sodium ›
- Acebutolol ›
- Acetazolamide ›
- Ambrisentan ›
- Amiloride ›
- Atenolol ›
- Betaxolol ›
- Bromfenac Sodium ›
- Candesartan Cilexetil ›
- Captopril ›
- Carteolol ›
- Carvedilol ›
- Chlorthalidone ›
- Cyclothiazide ›
- Dabigatran ›
- Diclofenac Epolamine ›
- Enalapril Maleate ›
- Felodipine ›
- Guanethidine Monosulfate ›
- Indapamide ›
- Irbesartan ›
- Labetalol ›
- Mannitol ›
- Methyclothiazide ›
- Methyldopa ›
- Metoprolol ›
- Nadolol ›
- Nebivolol ›
- Nimodipine ›
- Olmesartan Medoxomil ›
- Oxprenolol ›
- Pindolol ›
- Piroxicam ›
- Quinapril ›
- Reserpine ›
- Streptokinase ›
Showing 60 of 288 moderate interactions — see all 288 on the Conjugated Linoleic Acid (cla) page.
No interaction 2,541 drugs checked — show the list
We also checked Conjugated Linoleic Acid (cla) against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Ivermectin ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Tadalafil ›
- Abemaciclib ›
- Atorvastatin ›
- Docusate ›
- Valacyclovir ›
- Hydroxyurea ›
- Methamphetamine ›
- Tirzepatide ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Bupropion ›
- Bendamustine ›
- Amitriptyline ›
- Acyclovir ›
- Methotrexate ›
- Doxycycline ›
- Fluoxetine ›
- Amphetamine ›
- Lamotrigine ›
- Pregabalin ›
- Acetaminophen, Codeine ›
- Azithromycin ›
- Gabapentin ›
- Dextroamphetamine ›
- Isotretinoin ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Oxycodone ›
- Diazepam ›
- Dapsone ›
- Cephalexin ›
- Cyclopentolate ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Roxithromycin ›
- Atorvastatin Calcium ›
- Acetaminophen, Caffeine, Codeine ›
- Pegunigalsidase Alfa-iwxj ›
- Levetiracetam ›
- Finasteride ›
- Mirtazapine ›
Showing the 60 most looked-up of 2,541 medications checked with no known interaction — see the full Conjugated Linoleic Acid (cla) list.
Sources & How We Checked
Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference for vitamins, herbs and supplements — the basis for our interaction data.
- MedlinePlus, U.S. National Library of Medicine — NIH consumer drug information, used for the medication overviews.
- NIH Dietary Supplement Label Database (DSLD) — Official supplement product labels.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Iloprost Is Linked to Lower Levels of One Nutrient
Natural Medicines records Iloprost as a medicine that can lower these. This is not an interaction with Conjugated Linoleic Acid (cla) — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Read the full Iloprost nutrient depletion report ›
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Conjugated Linoleic Acid (cla) and Iloprost Together: Common Questions
Can you take Conjugated Linoleic Acid (cla) with Iloprost?
Why are there 2 interactions listed for Conjugated Linoleic Acid (cla) and Iloprost?
How serious is the Conjugated Linoleic Acid (cla) and Iloprost interaction?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.