Drug & supplement interaction

Conjugated Linoleic Acid (cla) + Ipilimumab

Ipilimumab brand name: Yervoy.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Conjugated Linoleic Acid (cla) and Ipilimumab in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Conjugated Linoleic Acid (cla) and Ipilimumab

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ipilimumab and Conjugated Linoleic Acid (cla) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Conjugated Linoleic Acid (cla) safety at a glance

Conjugated Linolei... overall Use caution Generally well tolerated short-term, but long-term safety is not fully established.
Pregnancy Likely Safe When used orally in amounts found in foods. There is insufficient reliable information available about the safety of CLA when used in medicinal amounts during p... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in amounts found in foods. There is insufficient reliable information available about the safety of CLA when used in medicinal amounts during p... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ipilimumab and Conjugated Linoleic Acid (cla)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Conjugated Linoleic Acid (cla) Does Interact With Other Medications

Conjugated Linoleic Acid (cla) has 289 moderate known drug interactions in our database — Ipilimumab isn’t one of them. If you take anything else, check it against the full list below.

Taking anything else?

Check Another of Your Medications Against Conjugated Linoleic Acid (cla)

Covers the 2,830 medications we’ve checked against Conjugated Linoleic Acid (cla). Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Conjugated Linoleic Acid (cla) and Ipilimumab May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 3 of them are worth acting on rather than waiting out — marked below.

  • Yellowing of the skin or eyes Worth acting on Additional detail

    Conjugated Linoleic Acid (cla)

    “Orally, clinical research shows that CLA 3 grams daily for 12 weeks does not affect liver outcome measures. However, there are at least two case reports of hepatotoxicity. Asthenia, jaundice, and pruritus were reported in a 46-year-old female who consumed CLA for two weeks. Abnormal liver enzyme levels returned to normal following discontinuation of CLA supplementation.”

    Conjugated Linoleic Acid (cla) · Natural Medicines adverse-effect record, reported in anorexia.

    3 sources cited
    1. 105809. Madry E, Malesza IJ, Subramaniapillai M, et al. Body fat changes and liver safety in obese and overweight women supplemented with conjugated linoleic acid: A 12-week randomised, double-blind, placebo-controlled trial. Nutrients. 2020;12(6):1811. PubMed
    2. 45483. Ramos, R., Mascarenhas, J., Duarte, P., Vicente, C., and Casteleiro, C. Conjugated linoleic acid-induced toxic hepatitis: first case report. Dig.Dis.Sci 2009;54(5):1141-1143. PubMed
    3. 91589. Nortadas R, Barata J. Fulminant hepatitis during self-medication with conjugated linoleic acid. Ann Hepatol. 2012;11(2):265-7. DOI

    Ipilimumab

    Listed in the ADVERSE REACTIONS section of the FDA label for Ipilimumab. Read the label on DailyMed ›

  • Liver problems Worth acting on Additional detail

    Conjugated Linoleic Acid (cla)

    “Orally, CLA is well tolerated when found in foods. When taken in medicinal amounts, CLA seems to be well tolerated.

    Most Common Adverse Effects:

    Orally: Diarrhea, dyspepsia, flatulence, loose stools, and nausea.

    Serious Adverse Effects (Rare) :

    Orally: Cases of hepatotoxicity have been reported.”

    Conjugated Linoleic Acid (cla) · Natural Medicines adverse-effect record, reported in diarrhea.

    Ipilimumab

    Listed in the ADVERSE REACTIONS section of the FDA label for Ipilimumab. Read the label on DailyMed ›

  • Bleeding or bruising Worth acting on Additional detail

    Conjugated Linoleic Acid (cla)

    “Orally, CLA may cause headache or fatigue. In one case report, a 50-year-old female presented with headache and subarachnoid hemorrhage due to reversible cerebral vasoconstriction syndrome (RCVS) after taking a combination product containing green tea, L-carnitine, and CLA for one week.”

    Conjugated Linoleic Acid (cla) · Natural Medicines adverse-effect record, reported in cluster headache.

    3 sources cited
    1. 3153. Blankson H, Stakkestad JA, Fagertun H, et al. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr 2000;130:2943-8. PubMed
    2. 45787. MacRedmond, R., Singhera, G., Attridge, S., Bahzad, M., Fava, C., Lai, Y., Hallstrand, T. S., and Dorscheid, D. R. Conjugated linoleic acid improves airway hyper-reactivity in overweight mild asthmatics. Clin.Exp.Allergy 2010;40(7):1071-1078. PubMed
    3. 97007. Costa I, Mendonca MD, Cruz E Silva V, Calado S, Viana-Baptista M. Herbal supplements association with reversible cerebral vasoconstriction syndrome: a case report. J Stroke Cerebrovasc Dis 2017;26(3):673-76. PubMed

    Ipilimumab

    Listed in the ADVERSE REACTIONS section of the FDA label for Ipilimumab. Read the label on DailyMed ›

  • Weight loss / Reduced appetite / Itching Additional detail

    Conjugated Linoleic Acid (cla)

    Recorded for Conjugated Linoleic Acid (cla) in the same Natural Medicines adverse-effect record shown under Yellowing of the skin or eyes above.

    Ipilimumab

    Listed in the ADVERSE REACTIONS section of the FDA label for Ipilimumab. Read the label on DailyMed ›

  • Stomach upset / Diarrhea reported in 7.3% of FDA reports for Ipilimumab Additional detail

    Conjugated Linoleic Acid (cla)

    “Orally, the most common adverse effect reported with CLA is gastrointestinal upset including diarrhea, constipation, nausea, loose stools, dyspepsia, bloating, and flatulence. Esophageal irritation was reported in one patient who bit open and swallowed a capsule containing CLA.”

    Conjugated Linoleic Acid (cla) · Natural Medicines adverse-effect record, reported in constipation.

    6 sources cited
    1. 3153. Blankson H, Stakkestad JA, Fagertun H, et al. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr 2000;130:2943-8. PubMed
    2. 4947. Gaullier JM, Halse J, Hoye K, et al. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. Am J Clin Nutr 2004;79:1118-25. PubMed
    3. 45280. Lambert, E. V., Goedecke, J. H., Bluett, K., Heggie, K., Claassen, A., Rae, D. E., West, S., Dugas, J., Dugas, L., Meltzeri, S., Charlton, K., and Mohede, I. Conjugated linoleic acid versus high-oleic acid sunflower oil: effects on energy metabolism, glu
    4. 45705. Wanders, A. J., Brouwer, I. A., Siebelink, E., and Katan, M. B. Effect of a high intake of conjugated linoleic acid on lipoprotein levels in healthy human subjects. PLoS.One. 2010;5(2):e9000. PubMed
    5. 45730. Aryaeian, N., Shahram, F., Djalali, M., Eshragian, M. R., Djazayeri, A., Sarrafnejad, A., Salimzadeh, A., Naderi, N., and Maryam, C. Effect of conjugated linoleic acids, vitamin E and their combination on the clinical outcome of Iranian adults with activ
    6. 111056. Liang CW, Cheng HY, Lee YH, Liou TH, Liao CD, Huang SW. Effects of conjugated linoleic acid and exercise on body composition and obesity: a systematic review and meta-analysis. Nutr Rev 2023;81(4):397-415. PubMed

    Ipilimumab

    Listed in the ADVERSE REACTIONS section of the FDA label for Ipilimumab, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

  • Constipation Additional detail

    Conjugated Linoleic Acid (cla)

    Recorded for Conjugated Linoleic Acid (cla) in the same Natural Medicines adverse-effect record shown under Stomach upset / Diarrhea above.

    Ipilimumab

    Listed in the ADVERSE REACTIONS section of the FDA label for Ipilimumab. Read the label on DailyMed ›

  • Tiredness reported in 3.9% of FDA reports for Ipilimumab Additional detail

    Conjugated Linoleic Acid (cla)

    Recorded for Conjugated Linoleic Acid (cla) in the same Natural Medicines adverse-effect record shown under Yellowing of the skin or eyes above.

    Ipilimumab

    Listed in the ADVERSE REACTIONS section of the FDA label for Ipilimumab, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Showing the 10 most notable of 12 shared effects — ranked by how unusual each one is, not just whether both lists mention it.

Reported for Conjugated Linoleic Acid (cla) but not commonly for Ipilimumab: bloating or gas.

Effects for Ipilimumab come from the ADVERSE REACTIONS section of its FDA label; effects for Conjugated Linoleic Acid (cla) come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 42,912 voluntary FDA FAERS reports for Ipilimumab that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Conjugated Linoleic Acid (cla) in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally in amounts found in foods. There is insufficient reliable information available about the safety of CLA when used in medicinal amounts during pregnancy or lactation; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Ipilimumab Is Prescribed For, and What Conjugated Linoleic Acid (cla) Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Ipilimumab is a prescription medicine with approved uses on its FDA label. Conjugated Linoleic Acid (cla) is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Ipilimumab is prescribed for: Yervoy (ipilimumab) is approved to treat a range of serious cancers. As a single agent, Yervoy treats unresectable or metastatic melanoma in adults and patients 12 and older, and is used as adjuvant therapy (after surgery) in adults with cutaneous melanoma that has spread to nearby lymph nodes. In combination with nivolumab, Yervoy treats unresectable or metastatic melanoma (adults and patients 12+), MSI-H or dMMR metastatic colorectal cancer (adults and patients 12+), advanced renal cell carcinoma, unresectable or metastatic hepatocellular carcinoma (liver cancer), metastatic non-small cell lung cancer, unresectable malignant pleural mesothelioma, and unresectable advanced or metastatic esophageal squamous cell carcinoma. Some uses require tumor testing first.

Read the rest of what Ipilimumab is prescribed for

For example, Yervoy combined with nivolumab for non-small cell lung cancer requires that the tumor expresses a protein called PD-L1 (≥1%), and colorectal cancer treatment requires confirmation of MSI-H or dMMR status — both determined by FDA-authorized tests.

Conjugated Linoleic Acid (cla) has been studied for:

  • Colorectal cancer studied, not established Conjugated Linoleic Acid (cla) has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Conjugated Linoleic Acid (cla) for colorectal cancer

    It is unclear if dietary CLA is beneficial for preventing colorectal cancer.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Ipilimumab on your own; if you are taking Conjugated Linoleic Acid (cla) for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

How much people look this up

Where Conjugated Linoleic Acid (cla) and Ipilimumab Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Conjugated Linoleic Acid (cla)
Steady interest

#1,022 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ipilimumab
Steady interest

#2,458 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Conjugated Linoleic Acid (cla) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Conjugated Linoleic Acid (cla) and Ipilimumab records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Conjugated Linoleic Acid (cla)

What is Conjugated Linoleic Acid (cla)?

Conjugated Linoleic Acid (cla)
  • Weight loss
  • Improving body composition
  • Sports and muscle support
  • Reducing inflammation
  • General wellness

CLA is a fatty acid found naturally in meat and dairy, and supplements are usually made from safflower oil. While it is popular for fat loss and body composition, research results are mixed and any real-world effect appears small at best. It is likely safe for short-term use in most healthy adults, but talk to your pharmacist or doctor before starting it.

Fatty acid (often sourced from safflower or sunflower oil) · Softgels, capsules, oil

An interaction check asks whether these two react with each other — it does not ask whether Conjugated Linoleic Acid (cla) is a good idea for someone in your situation. Here is what our Conjugated Linoleic Acid (cla) record says about it on its own.

Conjugated Linoleic Acid (cla): dosing

There is no official or standardized dose of CLA. Doses used in studies have varied widely, and it is not clear which amount, if any, is most effective.The best approach is to follow the directions on the product label and not exceed the recommended amount.

From our Conjugated Linoleic Acid (cla) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Conjugated Linoleic Acid (cla) monograph & all interactions
Medication

About Ipilimumab Injection

What Is Ipilimumab Injection Used For?

Brand name: Yervoy

Yervoy (ipilimumab) is approved to treat a range of serious cancers. As a single agent, Yervoy treats unresectable or metastatic melanoma in adults and patients 12 and older, and is used as adjuvant therapy (after surgery) in adults with cutaneous melanoma that has spread to nearby lymph nodes. In combination with nivolumab, Yervoy treats unresectable or metastatic melanoma (adults and patients 12+), MSI-H or dMMR metastatic colorectal cancer (adults and patients 12+), advanced renal cell carcinoma, unresectable or metastatic hepatocellular carcinoma (liver cancer), metastatic non-small cell lung cancer, unresectable malignant pleural mesothelioma, and unresectable advanced or metastatic esophageal squamous cell carcinoma.

Some uses require tumor testing first. For example, Yervoy combined with nivolumab for non-small cell lung cancer requires that the tumor expresses a protein called PD-L1 (≥1%), and colorectal cancer treatment requires confirmation of MSI-H or dMMR status — both determined by FDA-authorized tests.

Most-Reported Side Effects for Ipilimumab

From FAERS, the FDA’s public side-effect reporting system (42,912 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Malignant neoplasm progression 3,782 reports
Diarrhea 3,128 reports
Colitis 2,316 reports
Fever 2,057 reports
Rash 1,805 reports
See full Ipilimumab Injection drug information
Keep checking

Other Drugs & Conjugated Linoleic Acid (cla)

Browse every other medication we’ve checked against Conjugated Linoleic Acid (cla) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
289Moderate
0Minor
2,540No known interaction
Moderate

289 interactions

Showing 60 of 289 moderate interactions — see all 289 on the Conjugated Linoleic Acid (cla) page.

No interaction 2,540 drugs checked — show the list
Evidence & sources

Conjugated Linoleic Acid (cla) References

The 27 references that drive our Conjugated Linoleic Acid (cla) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Riserus U, Arner P, Brismar K, Vessby B. Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care 2002;25:1516-21.
  2. Blankson H, Stakkestad JA, Fagertun H, et al. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr 2000;130:2943-8. PubMed
  3. Gaullier JM, Halse J, Hoye K, et al. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. Am J Clin Nutr 2004;79:1118-25. PubMed
  4. Pariza M, Park Y, Cook ME. Conjugated linoleic acid and the control of cancer and obesity. Toxicol Sci 1999;52:107-10. DOI
  5. Kelly ML, Berry JR, Dwyer DA, et al. Dietary fatty acid sources affect conjugated linoleic acid concentrations in milk from lactating dairy cows. J Nutr 1998;128:881-5. PubMed
  6. Herbel BK, McGuire MK, McGuire MA, Shultz TD. Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans. Am J Clin Nutr 1998;67:332-7. PubMed
  7. Riserus U, Vessby B, Arner P, Zethelius B. Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity. Diabetologia 2004;47:1016-9. PubMed
  8. Nagao, K., Inoue, N., Wang, Y. M., Hirata, J., Shimada, Y., Nagao, T., Matsui, T., and Yanagita, T. The 10trans,12cis isomer of conjugated linoleic acid suppresses the development of hypertension in Otsuka Long-Evans Tokushima fatty rats. Biochem.Biophys PubMed
  9. Riserus, U., Vessby, B., Arnlov, J., and Basu, S. Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. Am J Clin Nutr 2004;80(2):279-283. PubMed
  10. Tricon, S., Burdge, G. C., Kew, S., Banerjee, T., Russell, J. J., Jones, E. L., Grimble, R. F., Williams, C. M., Yaqoob, P., and Calder, P. C. Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy huma
  11. Moloney, F., Yeow, T. P., Mullen, A., Nolan, J. J., and Roche, H. M. Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. Am J Clin Nutr 2004;80(4):887-895. PubMed
  12. Lambert, E. V., Goedecke, J. H., Bluett, K., Heggie, K., Claassen, A., Rae, D. E., West, S., Dugas, J., Dugas, L., Meltzeri, S., Charlton, K., and Mohede, I. Conjugated linoleic acid versus high-oleic acid sunflower oil: effects on energy metabolism, glu
  13. Tholstrup, T., Raff, M., Straarup, E. M., Lund, P., Basu, S., and Bruun, J. M. An oil mixture with trans-10, cis-12 conjugated linoleic acid increases markers of inflammation and in vivo lipid peroxidation compared with cis-9, trans-11 conjugated linolei
  14. Ramos, R., Mascarenhas, J., Duarte, P., Vicente, C., and Casteleiro, C. Conjugated linoleic acid-induced toxic hepatitis: first case report. Dig.Dis.Sci 2009;54(5):1141-1143. PubMed
  15. Ingelsson, E. and Riserus, U. Effects of trans10cis12CLA-induced insulin resistance on retinol-binding protein 4 concentrations in abdominally obese men. Diabetes Res Clin.Pract. 2008;82(3):e23-e24. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Conjugated Linoleic Acid (cla) and Ipilimumab Together: Common Questions

Is it safe to take Conjugated Linoleic Acid (cla) with Ipilimumab?
We do not list a known interaction between Conjugated Linoleic Acid (cla) and Ipilimumab. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Conjugated Linoleic Acid (cla) and Ipilimumab have any of the same side effects?
Yes — our sources link each of them separately to 10 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Conjugated Linoleic Acid (cla) and Ipilimumab used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Conjugated Linoleic Acid (cla) in each. That is a conversation for your prescriber, especially if Ipilimumab is being adjusted to a target.
Does Conjugated Linoleic Acid (cla) interact with any other medications?
Yes. Conjugated Linoleic Acid (cla) has 289 documented drug interactions in our database — Ipilimumab is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ipilimumab and Conjugated Linoleic Acid (cla)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.